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Showing 9 out of a total of 9 results for collection: Departament de Química Orgànica. (0.763 seconds)

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Síntesis estereoselectiva de azúcares y N-acetil iminoazúcares relacionados con enfermedades de depósito lisosomal

Fuente Cebrián, Àlex de la (Date of defense: 30-01-2015)
Los iminoazúcares son productos estructuralmente análogos a los azúcares convencionales en los que un nitrógeno se sitúa sustituyendo al oxígeno endocíclico. Son sustratos capaces de mimetizar la conformación y la carga ...
Synthesis of Highly Structured and Receptor-Selective Tetradecapeptidic Analogs of Somatostatin: Fine-tuning the non-covalent interactions among their aromatic residues

Martín-Gago, Pablo (Date of defense: 11-10-2013)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...
Reactivity and Applications of New Substrates for the Intermolecular Pauson-Khand Reaction: N-Boc-propargylamines and trifluoromethyl alkynes

Aiguabella Font, Nuria (Date of defense: 07-02-2014)
The Pauson-Khand reaction (PKR) is, formally, a [2+2+1] cycloaddition involving an alkene, an alkyne and a carbon monoxide molecule, typically mediated or catalyzed by a cobalt (0) complex. The product of this reaction is ...
Catálisis Asimétrica con complejos de rodio e iridio. Aplicación en síntesis de compuestos biológicamente activos

Cristóbal Lecina, Edgar (Date of defense: 29-09-2014)
La hidrogenación catalítica asimétrica es uno de los métodos más importantes en síntesis orgánica. Este proceso permite acceder a importantes productos quirales a escala multigramo utilizando hidrógeno (que es barato) y ...
Intermolecular Pauson-Khad reaction: study of the regioselectivity, photochemistry of the adducts and synthetic applications

Khaizourane, Héléa (Date of defense: 11-03-2016)
The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated [2+2+1] ...
Development of synthetic strategies for lasso peptides with anticancer activity

Martín Gómez, Helena (Date of defense: 23-02-2018)
Nowadays, the discovery and development of novel constrained peptides which are likely to combine the advantages of therapeutic proteins with those of small molecules is of special interest. This has partially prompted ...
Reaccions de Pauson-Khand amb alcoxialquins derivats d'alcohols quirals

Verdaguer i Espaulella, Xavier (Date of defense: 06-07-1994)
Se han estudiado las reacciones intramoleculares de Pauson-Khand de los eteres 3-alcoxialil propargílicos y 3-alcoxipropargil alílicos derivados del 2-neopentiloxi-3-bornanol y del 3-neopentiloxi-iso-borneol. Las ...
Syntheses of Protein Degraders and Compounds for Targeted Drug Release

Donoghue, Craig (Date of defense: 24-07-2019)
The thesis consists of two main projects: a) the development of a novel strategy to gain genetic control with spatiotemporal precision, and b) the optimisation of inhibitors of the protein kinase p38α, which has a major ...
Syntheses and applications of 3-bromo-1,2,4,5-tetrazines as novel tools for chemical biology

Ros Simó, Enric (Date of defense: 16-12-2020)
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due to their ability ...