Browsing Facultat de Química by Subject "577"

Chemically synthesized peptide libraries as a new source of BBB-shuttles. Use of Mass Spectrometry for peptide identification and quantification

Guixer, Bernat (Date of defense: 2014-03-31)

The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct function of this organ. ...

Computational Modelling of the pH Effect on Intrinsically Disordered Proteins

Privat Contreras, Cristian (Date of defense: 2023-04-20)

[eng] Intrinsically disordered proteins (IDPs) landed on the molecular biology framework at the turn of the 20th century to challenge the established protein function- structure paradigm. Due to their inherent flexibility ...

Exploring protein structure changes due to somatic mutations in cancer

Diéguez Docampo, Andrea (Date of defense: 2023-03-02)

[eng] Cancer is one of the most common diseases worldwide. Despite that a lot of time and resources have already been spent in this topic, there is still a long way to go to be able to cure every patient and improve their ...

Mecanismo cinético de la xantinoxidasa de hígado de buey y de la xantindeshidrogenasa de hígado de pollo

Canela Campos, Enric I. (Date of defense: 1976-12-16)

La xantinoxidasa (xantina: oxígeno-oxidorreductasa) fue descubierta por HORBACZEWSKI y SPITZER al observar que la hipoxantina y la xantina, en presencia de varios preparados tisulares, daban lugar a la aparición de ácido ...

Novel Disulfide Formation Strategies in Peptide Synthesis

Postma, Tobias Maria (Date of defense: 2014-03-21)

Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...

Protease inhibitors as therapeutic agents

Mendieta Martínez, Laura (Date of defense: 2014-06-06)

Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study in four proteases: ...

Protein Flexibility: From local to global motions. A computational study

Sánchez Martínez, Melchor (Date of defense: 2014-12-09)

Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange of conformations, ...

Small molecules for modulating biological targets

Miret Casals, Laia (Date of defense: 2014-05-23)

CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic conditions such as ...

Study of the aggregation process of the amyloid beta-protein associated to Alzheimer's disease. Examination of pharmaceutically important small molecules.

Serra Vidal, Bernat (Date of defense: 2014-05-27)

Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...