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Structural studies of Heteromeric Amino acid Transporters (HATs): Validation of the first 3D structural model of a HAT (human 4F2hc/LAT2) and identification of new HAT targets for 3D‐crystallization

Álvarez Marimón, Mª Elena (Date of defense: 27-10-2014)
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide bridge. Genetic defects ...
Functional studies of 4F2hc-CD147 interaction = Estudios funcionales de la interacción 4F2hc‐CD147

Delgado Martin, Gonzalo (Date of defense: 14-07-2014)
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...