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Showing 10 out of a total of 33 results for collection: Departament de Bioquímica i Biologia Molecular (Biologia). (1.585 seconds)
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(Date of defense: 19-07-2012)Targeted protein degradation plays a central role in eukaryotic cell regulation and homeostasis. The ubiquitin proteasome system (UPS) is involved in a large number of cellular events, being, day by day, more difficult to ...
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(Date of defense: 24-01-2014)Lycopene is an antioxidant carotenoid present in high amounts inside the ripe tomato fruit, in watermelon, red bell pepper and a few other red-pigmented fruits. Its health benefits, notably the prevention of prostate cancer ...
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(Date of defense: 28-06-2013)Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, and few computer ...
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(Date of defense: 27-10-2014)Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide bridge. Genetic defects ...
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(Date of defense: 05-02-2016)The aim of this thesis is to develop standard and practical approaches for the semantic integration of biological data and services. The thesis considers various scenarios where ontologies may benefit bioinformatics web ...
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(Date of defense: 04-05-2012)During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical molecules with high ...
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(Date of defense: 10-07-2013)Neuregulin (NRG), which structurally belongs to an EGF family of growth factors, activated in acute manner signaling cascades that lead to changes in whole-body glucose metabolism in fasted mice. Besides previously observed ...
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(Date of defense: 03-12-2013)Nucleoside-derived drugs are used for the treatment of haematological malignancies, viral infections and autoimmune or inflammatory diseases. These drugs require membrane transporters to be internalised and be active. ...
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(Date of defense: 01-12-2016)Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
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Functional studies of 4F2hc-CD147 interaction = Estudios funcionales de la interacción 4F2hc‐CD147 (Date of defense: 14-07-2014)We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...
