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Showing 10 out of a total of 32 results for collection: Departament de Bioquímica i Biologia Molecular (Biologia). (1.483 seconds)

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Characterization of Rpn10 monoubiquitination as a novel way of proteasome regulation

Isasa Catalán, Marta (Date of defense: 19-07-2012)
Targeted protein degradation plays a central role in eukaryotic cell regulation and homeostasis. The ubiquitin proteasome system (UPS) is involved in a large number of cellular events, being, day by day, more difficult to ...
New insights into carotenoid accumulation in tomato fruit = Nuevos aspectos sobre acumulación de carotenoides en el fruto del tomate

Pourcq, Karel de (Date of defense: 24-01-2014)
Lycopene is an antioxidant carotenoid present in high amounts inside the ripe tomato fruit, in watermelon, red bell pepper and a few other red-pigmented fruits. Its health benefits, notably the prevention of prostate cancer ...
Structural prediction and characterization of protein-RNA interactions / Predicción y caracterización estructural de interacciones proteína-ARN

Pérez Cano, Laura (Date of defense: 28-06-2013)
Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, and few computer ...
Structural studies of Heteromeric Amino acid Transporters (HATs): Validation of the first 3D structural model of a HAT (human 4F2hc/LAT2) and identification of new HAT targets for 3D‐crystallization

Álvarez Marimón, Mª Elena (Date of defense: 27-10-2014)
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide bridge. Genetic defects ...
Ontology based data integration in life sciences

Repchevskiy, Dmitry (Date of defense: 05-02-2016)
The aim of this thesis is to develop standard and practical approaches for the semantic integration of biological data and services. The thesis considers various scenarios where ontologies may benefit bioinformatics web ...
Study of the Electron-Transfer properties of phenolics and their relationship with the biological activity on cancer cells

Carreras Cardona, Anna (Date of defense: 04-05-2012)
During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical molecules with high ...
Neuregulin reduces glycaemia by targeting liver metabolism

Niisuke, Katrin (Date of defense: 10-07-2013)
Neuregulin (NRG), which structurally belongs to an EGF family of growth factors, activated in acute manner signaling cascades that lead to changes in whole-body glucose metabolism in fasted mice. Besides previously observed ...
Impact of membrane transporters polymorphisms on nucleoside-derived drug bioavailability and action = Impacte dels polimorfismes en transportadors de membrana en la biodisponibilitat i acció de fàrmacs anàlegs de nucleòsids

Arimany Nardi, Cristina (Date of defense: 03-12-2013)
Nucleoside-derived drugs are used for the treatment of haematological malignancies, viral infections and autoimmune or inflammatory diseases. These drugs require membrane transporters to be internalised and be active. ...
Role of DOR/TP53INP2 in the control of muscle protein degradation = Papel de DOR/TP53INP2 en el control de la degradación de proteínas en el músculo esquelético

Martinez Cristobal, Paula (Date of defense: 01-12-2016)
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
Functional studies of 4F2hc-CD147 interaction = Estudios funcionales de la interacción 4F2hc‐CD147

Delgado Martin, Gonzalo (Date of defense: 14-07-2014)
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...