Departament de Bioquímica i Biologia Molecular (Biologia): Recent submissions
Now showing items 11-30 of 156
Heteroligomeric interactions of the Kv1.3 channelosome
Voltage-gated potassium channels are proteins that allow the flux of potassium ions across the plasma membrane in response to a voltage stimulus. Those proteins were initially described in nervous system as the repolarization ...
Role of DOR/TP53INP2 in the control of muscle protein degradation = Papel de DOR/TP53INP2 en el control de la degradación de proteínas en el músculo esquelético
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
Functional role of pentose phosphate pathway and glutamine in cancer cell metabolism
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
4F2hc/LAT1 heterodimer: a promising candidate for solving the first atomic structure of a heteromeric amino acid transporter = Heterodímero 4F2hc/LAT1: un candidato prometedor para resolver la primera estructura atómica de un transportador heteromérico de aminoácidos
Heteromeric amino acid transporters (HATs) are the unique solute transporters known to be composed of two subunits linked by a disulphide bridge. The heavy subunit (4F2hc or rBAT), a type II membrane N-glycoprotein that ...
Characterization of endothelial cell metabolism under different microenvironmental challenges: exploring therapeutic implications of targeting glycogen degradation
Angiogenesis is the formation of blood vessels from the pre-existing ones and is required for distributing nutrients and oxygen to the tissues through the blood flow. This process is important for tumour tissues as well, ...
Kv1.3 and Kv1.5 channels in leukocytes
Voltage dependent potassium channels are a group of plasma membrane ion channels with a key role in the immune system as the predominant ion channels controlling the resting membrane potential and tuning intracellular Ca2+ ...
Estudio de los mecanismos terapéuticos en la inducción de tolerancia inmunológica en un modelo animal de esclerosis múltiple
La terapia génica puede ser una herramienta para inducir tolerancia inmunológica de forma experimental. Nuestro trabajo anterior mostró que la transferencia de células de médula ósea que habían sido transducidas con un ...
La transferència de coneixement en el sector biotecnològic: un model alternatiu pel desenvolupament socioeconòmic
Els baixos resultats obtinguts en els indicadors de transferència de tecnologia des de les universitats i centres públics de recerca a empreses a Catalunya indiquen que aquesta no és una tasca fàcil. Tot i que hi la qualitat ...
Ontology based data integration in life sciences
The aim of this thesis is to develop standard and practical approaches for the semantic integration of biological data and services. The thesis considers various scenarios where ontologies may benefit bioinformatics web ...
A novel role for glycogenin in the regulation of glycogen metabolism
Glycogen synthesis is crucial for storing glucose residues that are released in case of energy demand. The mechanism needs to be tightly regulated because a lack or an overload of glycogen can lead to severe systemic ...
Characterization of alternative therapeutic sites on the androgen receptor and novel protein-protein associations
The androgen receptor (AR) is a ligand-activated transcription factor that plays a crucial role in the correct development, differentiation, and function of male reproductive organs. Alterations in the AR protein or in the ...
Cardiovascular Kv7 channels in health and in disease
Voltage-gated K+ channels, Kv channels, are the most diverse group of K+ channels. They have several key functions in cardiovascular and nervous system; setting the resting membrane potential and controlling the repolarization ...
Nous actors moleculars en la fisiologia del teixit adipós i patologies associades
El teixit adipós ha passat d’ésser considerat un mer reservori d’energia a un òrgan complex, implicat de forma activa en l’homeòstasi energètica i amb funcions endocrines de rellevància. Les malalties en què hi està ...
Targeting metabolic reprogramming associated to cancer cells: search of novel targets and combined therapies in cancer treatment
Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Colon and lung cancer ...
Nuevos factores implicados en las adaptaciones fisiológicas y cardiacas de la gestación
La gestación es un periodo en el que acontecen varios cambios fisiológicos. Los cambios metabólicos que acontecen en la primera mitad de la gestación (denominada anabólicos materna) consisten en una serie de adaptaciones ...
Regulación de la biosíntesis de isoprenoides en Arabidopsis thaliana: Caracterización del mutante rif35
Las plantas sintetizan una gran variedad de compuestos isoprenoides esenciales para su crecimiento y desarrollo. Sin embargo, la mayoría de los isoprenoides vegetales se incluyen en el grupo de los metabolitos secundarios ...
Nuevas aproximaciones al estudio del metabolismo de los esteroles en tomate
La producción de isoprenoides en tomate (Solanum lycopersicum) tiene gran importancia e interés tanto biológico como económico ya que son metabolitos especializados que participan en respuesta a factores bióticos y abióticos. ...
Teràpia multimodal per al tractament de la caquèxia cancerosa
La caquèxia és una síndrome clínicament evident en la seva fase avançada ja que es manifesta amb pèrdua substancial de greix i múscul esquelètic. Pels malalts els representa, en aquesta última etapa, una reduïda probabilitat ...
Development and application of novel model-driven and data-driven approaches to study metabolism in the framework of systems medicine
The general aim of this thesis is to develop and apply new computational tools to overcome existing limitations in the analysis of metabolism. This thesis is focused on developing new computational strategies to overcome ...
Desarrollo de una escala numérica para clasificar grados de caquexia en cáncer
Cachexia SCOre (CASCO) es una nueva herramienta cuantitativa para la clasificación de la caquexia cancerosa en pacientes. La escala incluye cinco componentes: 1) pérdida de peso y composición corporal, 2) inflamación / ...
