Now showing items 6-25 of 156
Mata i Ventosa, Aida (Date of defense: 2019-11-29)
L’entrada de nucleòsids a la cèl·lula està regulada pels transportadors concentratius de nucleòsids (hCNTs, família gènica SLC28) i transportadors equilibratius de nucleòsids (hENTs, família gènica SLC29). S’ha descrit que ...
Clavé Safont, Sergi (Date of defense: 2019-11-25)
El càncer de pulmó de cèl·lula no petita (CPCNP) es pot definir a nivell molecular per les alteracions genètiques que es produeixen en múltiples oncogens, inclosos els reordenaments dels gens ALK i ROS1. Per optimitzar el ...
Giménez Oya, Víctor (Date of defense: 2009-12-09)
Los isoprenoides son una de las mayores familias de compuestos descritos en la naturaleza. Estos compuestos están presentes en todos los organismos vivos y se sintetizan a partir de dos moléculas de 5 átomos de carbono: ...
Rotondo, Floriana (Date of defense: 2018-02-19)
The current theories about endothelial inflammation in the adipose tissue in metabolic syndrome point to hypoxia as one of its main causes. Nevertheless, our group has found that both 3T3L1 adipocytes, under normoxic ...
Enciso Salas, Hilda Yuliana (Date of defense: 2017-09-22)
TP53INP2 es una proteína nuclear que activa la autofagia en moscas y células eucariotas. El propósito de esta tesis doctoral fue investigar si TP53INP2 modula la autofagia mitocondrial dependiente de Parkin. Aquí, se ...
Roig Merino, Sara Raquel (Date of defense: 2017-05-05)
Voltage-gated potassium channels are proteins that allow the flux of potassium ions across the plasma membrane in response to a voltage stimulus. Those proteins were initially described in nervous system as the repolarization ...
Martinez Cristobal, Paula (Date of defense: 2016-12-01)
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
Polat, Ibrahim H. (Date of defense: 2016-11-04)
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
Obando Martínez, Ana Zuleima (Date of defense: 2016-05-19)
Heteromeric amino acid transporters (HATs) are the unique solute transporters known to be composed of two subunits linked by a disulphide bridge. The heavy subunit (4F2hc or rBAT), a type II membrane N-glycoprotein that ...
Jayaraman, Anusha (Date of defense: 2016-07-05)
Angiogenesis is the formation of blood vessels from the pre-existing ones and is required for distributing nutrients and oxygen to the tissues through the blood flow. This process is important for tumour tissues as well, ...
Vallejo Gracia, Albert (Date of defense: 2016-04-15)
Voltage dependent potassium channels are a group of plasma membrane ion channels with a key role in the immune system as the predominant ion channels controlling the resting membrane potential and tuning intracellular Ca2+ ...
Gómez Morago, Alba (Date of defense: 2016-02-10)
La terapia génica puede ser una herramienta para inducir tolerancia inmunológica de forma experimental. Nuestro trabajo anterior mostró que la transferencia de células de médula ósea que habían sido transducidas con un ...
Valle Álvaro, Elisabet del (Date of defense: 2016-02-09)
Els baixos resultats obtinguts en els indicadors de transferència de tecnologia des de les universitats i centres públics de recerca a empreses a Catalunya indiquen que aquesta no és una tasca fàcil. Tot i que hi la qualitat ...
Repchevskiy, Dmitry (Date of defense: 2016-02-05)
The aim of this thesis is to develop standard and practical approaches for the semantic integration of biological data and services. The thesis considers various scenarios where ontologies may benefit bioinformatics web ...
Testoni, Giorgia (Date of defense: 2016-02-05)
Glycogen synthesis is crucial for storing glucose residues that are released in case of energy demand. The mechanism needs to be tightly regulated because a lack or an overload of glycogen can lead to severe systemic ...
Rodríguez Carbó, Laia (Date of defense: 2016-01-25)
The androgen receptor (AR) is a ligand-activated transcription factor that plays a crucial role in the correct development, differentiation, and function of male reproductive organs. Alterations in the AR protein or in the ...
Oliveras Martínez, Anna (Date of defense: 2015-12-18)
Voltage-gated K+ channels, Kv channels, are the most diverse group of K+ channels. They have several key functions in cardiovascular and nervous system; setting the resting membrane potential and controlling the repolarization ...
Cereijo Téllez, Rubén (Date of defense: 2015-12-17)
El teixit adipós ha passat d’ésser considerat un mer reservori d’energia a un òrgan complex, implicat de forma activa en l’homeòstasi energètica i amb funcions endocrines de rellevància. Les malalties en què hi està ...
Tarrado Castellarnau, Miriam Neus (Date of defense: 2015-12-11)
Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Colon and lung cancer ...
Redondo Angulo, Ibon (Date of defense: 2016-01-28)
La gestación es un periodo en el que acontecen varios cambios fisiológicos. Los cambios metabólicos que acontecen en la primera mitad de la gestación (denominada anabólicos materna) consisten en una serie de adaptaciones ...