Rodón Ahnert, Laura (Date of defense: 2012-11-28)
The TGF-β pathway is currently considered a therapeutic target in advanced tumors, including glioblastoma (GBM), and several anti-TGFβ agents are in clinical trials and have shown promising results .A ...
Eibes González, Susana (Date of defense: 2016-09-13)
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this ...
Meca-Cortés, Oscar (Date of defense: 2014-12-17)
The transcription factor SOX2 is a key determinant of stem cell properties, also involved in the initiation, maintenance and progression of several human cancers. By studying the in ...
Celià Terrassa, Antoni (Date of defense: 2012-05-14)
This Doctoral Thesis project is part of a broader research program whose global aim is to better understand key molecular and cellular events in tumor metastasis, in particular those associated with ...
García Cordente, Antonio Felipe (Date of defense: 2006-06-22)
In eukaryotes, L-carnitine is involved in energy metabolism, where it facilitates b-oxidation of fatty acids. Carnitine acyltransferases catalyze the reversible conversion of acyl-CoA and carnitine to ...
Amara, Imen (Date of defense: 2012-07-12)
In order to improve our understanding on LEA proteins and their molecular functions in drought tolerance, the present work analyzes in the first place, the composition of LEA subproteomes from Arabidopsis ...
Szekrényi, Anna (Date of defense: 2014-07-25)
Biocatalysis is the chemical transformation of organic substrates by enzymes. This is the driving force of some of the oldest transformations known to humans. Nowadays, methods involving biocatalysts ...
De Sousa Coelho, Ana Luisa (Date of defense: 2012-06-25)
1- ROLE OF SIRT1 IN THE REGULATION OF FATTY ACID OXIDATION AND KETOGENESIS UNDER DIFFERENT NUTRIONAL CHANGES. The homolog of the yeast silencing information regulator2 (SIRT1) has been implicated in ...
Bertran Domingo, M. Teresa (Date of defense: 2012-11-29)
Nek9 is a NIMA-related kinase that is phosphorylated in mitosis and a small pool of it (5%) is activated at the centrosomes by a complex mechanism which has remained elusive until now. Nek6 and Nek7 ...
Robert Moreno, Alexandre (Date of defense: 2007-09-28)
The process that gives rise to all the mature blood cells from the HSCs (Hematopoietic Stem Cells) is known as hematopoiesis. In the adult, hematopoiesis takes place in the bone marrow although the HSCs ...