López Pelegrín, Maria del Mar (Date of defense: 2015-11-13)
Metallopeptidases are major players in the physiology and pathology of all living organisms. Their exquisite regulation is therefore essential for proper function and to prevent misdirected temporal ...
Malandrino, Maria Ida (Date of defense: 2013-10-04)
Current lifestyle with high-energy diets and little exercise is triggering an alarming growth in obesity. Excess of adiposity is leading to severe increase in associated pathologies, such as insulin ...
Fajardo Calderón, Carlos Alberto (Date of defense: 2017-05-19)
Oncolytic adenoviruses that selectively replicate in cancer cells while sparing normal tissue have gained considerable attention as novel anticancer drugs. However, clinical trials with these viruses ...
Ventura Ventanachs, Verònica (Date of defense: 2013-10-18)
Irosustat is a first-generation, irreversible, steroid sulfatase inhibitor currently in development for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin-based sulfamate that ...
Robles García, Virginia (Date of defense: 2014-12-05)
Clathrin is an evolutionary conserved molecule that coats membranes endocytosed from the plasma membrane and those that move between the trans-Golgi network (TGN) and endosomes of eukaryotic cells. It ...
Rodríguez Banqueri, Arturo (Date of defense: 2013-03-14)
X-ray crystallography is, now at days, one of the most powerful techniques to study proteins at the atomic level. Unfortunately, obtaining high quality crystals of membrane proteins for x-ray diffraction ...
Amo Maestro, Laura del (Date of defense: 2021-06-11)
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and ...
González-Ortega, Emmanuel (Date of defense: 2012-07-23)
There are several reasons to celebrate the latest advances in the treatment of the infection with HIV. According to the Joint United Nations Programme on HIV/AIDS, the number of new infections dropped ...
Kaczmarska, Zuzanna (Date of defense: 2014-12-05)
Picornaviridae are among the most diverse and oldest known viral families that include many important pathogens of humans and animals. They are small, icosahedral (+)ssRNA viruses, causing a variety of ...
Villalobos Alberú, Xenia (Date of defense: 2015-12-22)
This work is focused on the study of the stability and immunogenic properties of the Polypurine Reverse Hoogsteen hairpins (PPRHs), and on their use as a gene-silencing tool. PPRHs are non-modified DNA ...