A Computational toolkit to boost precision oncology with pharmacogenomics 

    Mateo Ramos, Lídia (Fecha de defensa: 2019-12-18)

    Durant la darrera dècada la seqüenciació massiva de pacients de cancer ha permés avançar de forma significativa el coneixement sobre les bases moleculars del càncer. Un cop assolit aquest primer pass, el repte que tenim ...

    A new Ligand-Based approach to virtual screening, and prolifing or large chemical libraries 

    Gregori Puigjané, Elisabet (Fecha de defensa: 2008-07-08)

    La representació de les molècules per mitjà de descriptors moleculars és la base de moltes de les eines computacionals pel disseny de fàrmacs. Aquests mètodes computacionals es basen en l'abstracció de l'estructura química ...

    Adjuvant dendritic mesoporous silica nanoparticles as sustained delivery system for peptide-based vaccine 

    An, Weiteng (Fecha de defensa: 2021-04-14)

    Peptide-based vaccines have raised as an attractive alternative strategy to overcome many of the limitations of conventional vaccines. Some drawbacks for an optimal immune response in vivo are, a poor immunogenicity, ...

    Applications of molecular dynamics in drug discovery and technology transfer via a web-based platform 

    Martínez Rosell, Gerard (Fecha de defensa: 2017-12-20)

    In this thesis we apply molecular dynamics (MD) simulations and other in silico techniques in drug discovery. Specifically, (a) we developed an algorithm to detect cryptic pockets based on MD simulations of the protein ...

    Approaches to evaluate the pharmacology of new psychoactive substances 

    Olesti Muñoz, Eulàlia (Fecha de defensa: 2018-11-29)

    In the last decade, the rapid emergence of a group of compounds known as novel psychoactive substances (NPS) has become a worrying problem due to their ambiguous legal status, their easy availability, their extensive ...

    Assessing human growth hormone variants to determine their potential relevance in anti-doping and clinical analysis 

    Such Sanmartin, Gerard (Fecha de defensa: 2010-01-28)

    Human growth hormone (GH) participates in human longitudinal growth, lipid and carbohydrate metabolism, and comprises a remarkably number of proteins with similar sequences, generated either genetically or post-translationally, ...

    Assessment of growth hormone secretagogues in anti-doping 

    Pinyot Comelles, Armand (Fecha de defensa: 2012-10-24)

    La present tesis doctoral desenvolupa una nova metodologia analítica antidopatge. Degut a que actualment la detecció de l'abús d'hormona del creixement recombinant està relativament resolt, es tem que els secretagogs de ...

    Blending biology and chemistry to enable systems pharmacology 

    Duran-Frigola, Miquel (Fecha de defensa: 2016-01-28)

    The avalanche of data that followed the sequencing of the human genome has revealed an overwhelming biological complexity. No simple molecular explanation exists for most of the diseases and, in consequence, simple therapies ...

    Cancer risk among children exposed to medical ionising radiation and modifying factors - evidence from paediatric CT exposure in Sweden 

    Canet, Maëlle (Fecha de defensa: 2023-03-30)

    Though Computed Tomography (CT) plays an essential role in healthcare, several large-scale cohort studies have reported an increased cancer risk following CT-radiation exposure in childhood. Results may be subject to ...

    Cannabidiol as a potential therapeutic strategy to reduce cocaine seeking in mice 

    Luján Pérez, Miguel Ángel (Fecha de defensa: 2020-03-13)

    Cocaine addiction is a chronic, relapsing disease characterized by the compulsive seeking and use of the drug despite its harmful consequences. Currently, there are no approved pharmacotherapies available for the treatment ...

    Cell-penetrating peptides as drug shuttles for pain management and other therapeutic applications 

    Gallo, María (Fecha de defensa: 2021-07-22)

    This thesis focuses on one of the biggest challenges facing drug discovery field: the efficient targeted delivery of therapeutic compounds, and how cell-penetrating peptides (CPPs) acting as drug delivery vectors can ...

    Characteristics and uses of dual-spiral dual-energy CT in radiotherapy of the head and neck 

    Fernández-Velilla Cepria, Enric (Fecha de defensa: 2023-01-25)

    Dual-Spiral Dual-Energy Computed Tomography is an emerging technology that is being introduced in Radiotherapy Departments of hospitals because of its cost and simplicity. There is still a lack of literature about its ...

    Chemoisosterism and its impact on drug polypharmacology 

    Jalencas i Giménez, Xavier (Fecha de defensa: 2013-09-17)

    In medicinal chemistry, two chemical fragments are considered bioisosteric if they bind to the same protein environment. Accordingly, looking at the same players from an opposite perspective, two protein environments can ...

    Chimeric synthetic peptides as diagnostic tools : a novel IgM-specific immunoassay for the diagnosis of toxoplasmosis : Driving innovation towards next-generation IgM immunoassays 

    Ripoll Pastor, Greta (Fecha de defensa: 2021-05-10)

    Serologic tests detecting anti- T. gondii IgM are the gold standard for the diagnosis of acute toxoplasmosis. Nevertheless, most commercial kits are based on lysate antigens obtained from tachyzoites grown in mice or tissue ...

    Clinical and toxicological significance of the involvement of the cytocrhome p450 system in the metabolism of 3,4-methylenedioxymethamphetamine 

    O'Mahony, Brian (Fecha de defensa: 2008-11-17)

    La 3,4-metilenodioximetanfetamina (MDMA, éxtasis) es una anfetamina sustituida de consumo frecuente y abusivo. La enzima principal que participa en el metabolismo de fase I de la MDMA, la isoforma 2D6 (CYP2D6) del citocromo ...

    Comparative study of dedicated Monte Carlo simulation codes for the performance evaluation of the small animal PET systems 

    Popota, Foteini D. (Fecha de defensa: 2014-11-27)

    Positron emission tomography (PET) has been well established the last years as a powerfull tool in research and clinical applications. Advances in technology have enabled the use of small animal PET imaging in preclinical ...

    Control de qualitat en mètodes d'anàlisi qualitatius i la seva aplicació al control antidopatge 

    Jiménez Otero, Cintia (Fecha de defensa: 2007-01-12)

    L'anàlisi qualitatiu ha estat sempre molt important en el control antidopatge i constitueix cada cop més una part molt significativa de l'activitat diària d'altres tipus de laboratoris. Tanmateix, no existeixen guies o ...

    Control of anabolic steroids misuse in sport : potential of direct detection of phase II metabolites 

    Esquivel López, Argitxu (Fecha de defensa: 2018-12-14)

    Anabolic androgenic steroids (AAS) are widely used by athletes to enhance sports performance. In this thesis, different studies were performed to evaluate the potential of the direct detection of phase II metabolites by ...

    CT scans in children and young adults and cancer risk: the Spanish EPI-CT cohort 

    Bosch de Basea i Gómez, Magda (Fecha de defensa: 2016-11-28)

    The present thesis introduces the EPI-CT cohort study; a European collaborative effort aimed at quantifying the health risks of computed tomography (CT scan) radiation exposure during childhood and assesses the main ...

    Deep learning for drug design : modeling molecular shapes 

    Skalic, Miha (Fecha de defensa: 2019-07-30)

    Designing novel drugs is a complex process which requires finding molecules in a vast chemical space that bind to a specific biomolecular target and have favorable physio-chemical properties. Machine learning methods can ...