Universitat Pompeu Fabra
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Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...
Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics ...
Tumors are complex masses composed by multiple cell types, such as cancer associated fibroblasts (CAFs) and macrophages, that interact with each other promoting the tumor progression. Snail1 is a transcription factor ...
Esta tesis se interesa por distinguir entre los efectos directos de los receptores nucleares y aquellos mediados por las rutas de transducción de señales en la transcripción de genes en respuesta a hormona y proliferación ...
Objetivo: 1) Evaluar la asociación entre medidas clínicas, (Agudeza visual (AV), sensibilidad al contraste, (SC) y estereopsis) y el índice de función visual (VF-14). 2) Evaluar el impacto de la AV y SC sobre la ...
The general objective of this dissertation is to study breast cancer screening and specifically social inequalities by social class and country of origin and its relationship with decreasing mortality. Therefore, four ...
Despite decades of scientific effort, cancer remains a major cause of death worldwide. Through the accumulation of genome alterations, tumor populations evolve the capacity to circumvent the selective barriers of tissue ...
Recent human and animal data indicate that night shift work might increase the risk for cancer. Epidemiologic evidence is limited and has mostly focused on breast cancer while underlying mechanisms are still poorly understood. ...
El cáncer de mama HER2-positivo es un subtipo muy agresivo. El desarrollo de terapias anti-diana HER2, particularmente el anticuerpo monoclonal (Mab) trastuzumab, supuso una mejora significativa en el pronóstico de esta ...
En la presente tesis doctoral se ha realizado un estudio de investigación encaminado a definir los genes responsables que causan hipercrecimiento en humanos, así como la identificación y caracterización de las mutaciones ...
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main issues: the development ...
Pancreatic cancer is nowadays one of the neoplasms with worst prognosis, so research towards the discovery of new molecular targets for therapy and diagnosis is more than urgent. In this direction, we have deeply evaluated ...
Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are exploiting these technologies ...
In my thesis, I focused on integrative analysis of high-throughput oncogenomic data. This was done in two parts: In the first part, I describe IntOGen, an integrative data mining tool for the study of cancer. This system ...
The difficulty of increasing taxane production and reducing its costs has prompted a search for new biotechnological sources. The unexpected discovery of taxanes in Corylus avellana has generated considerable interest in ...
Cancer stem cells (CSCs) fuels tumours and are involved in therapy resistance, yet their contribution immunotherapy resistance and immunological properties are poorly understood. Herein, we show that within tumour phenotypic ...
El cáncer de mama es el cáncer más frecuente en las mujeres. Actualmente, en muchos países hay implantado un programa poblacional de detección precoz del cáncer de mama. Estos programas, entre otros beneficios, cuentan con ...
La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars. Investigacions anteriors del nostre laboratori han demostrat la importància ...
La present tesi avalua les diferències entre homes i dones quant a les característiques sociodemogràfiques i clínicopatològiques, procés diagnòstic, tractament i pronòstic en una sèrie de casos diagnosticats de novo de ...
DNA methylation is an essential epigenetic mechanism that regulates gene expression. While DNA methylation dynamics during embryonic formation is fairly well understood, its role in adult tissues is still under investigation. ...
