Now showing items 1-20 of 30
Dalmases Massegú, Alba (Date of defense: 2012-06-22)
EGFR is a transmembrane tyrosine kinase receptor from the HER family which, upon ligand stimulation, activates different signaling pathways involved in tumorogenesis. EGFR can be targeted by monoclonal antibodies, as ...
Mohan, Ram (Date of defense: 2011-05-30)
El adenocarcinoma ductal pancreático (PDAC) es la quinta causa de muerte por cáncer en los países desarrollados y uno de los tumores humanos más agresivos. A pesar del papel clave de la angiogénesis -la formación de ...
Mina Ibarra, Leonardo Bruno (Date of defense: 2010-05-21)
The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides acting as messengers for ...
Pérez Vilaró, Gemma (Date of defense: 2012-11-16)
Els cossos de processament (cossos-P) són grànuls discrets i dinàmics que contenen mRNAs represos en la traducció així com proteïnes involucrades en la degradació dels mRNAs i de la maquinària dels miRNAs. Alguns components ...
Sampera Borràs, Aïda (Date of defense: 2018-11-20)
The HER2 receptor is overexpressed in 7-34% of gastric cancer (GC) tumors, being a potential therapeutic target. Trastuzumab, an anti-HER2 monoclonal antibody, in combination with platinum therapy was approved in 2010 as ...
Marfil Vives, Vanessa (Date of defense: 2010-07-22)
Hhex transcription factor is expressed in multiple endoderm-derived tissues, like the liver, where it is essential for proper development. The pleiotropic effect of Hhex in the embryo and its dual role as a transcriptional ...
Radosevic, Aleksandar (Date of defense: 2021-06-02)
La ablación con radiofrecuencia y microondas son opciones terapéuticas útiles para el tratamiento de tumores malignos hepáticos en pacientes seleccionados. Aunque comparables, sus resultados son todavía inferiores a los ...
Pizarro Díaz, Vladimir (Date of defense: 2006-06-24)
La existencia de desigualdades socio-económicas en el estado de salud dentalde los ancianos no institucionalizados de la ciudad de Barcelona, sumado a labaja utilización de servicios odontológicos, indican un problema de ...
Massumi, Mohammad (Date of defense: 2009-12-18)
A pesar de la abundancia de estudios realizados sobre el papel de las células acinares en las patologías exocrinas del páncreas (i.e. pancreatitis y cáncer), el estudio de las modificaciones producidas durante la diferenciación ...
Künnemann, Kathi (Date of defense: 2013-09-13)
Cyclin O, a novel identified Cdk1 and Cdk2-binding cyclin, has been demonstrated to be required for apoptosis induced by intrinsic apoptotic stimuli. Because proteins implicated in apoptosis are often deregulated in ...
Pañella Vilamú, Clara (Date of defense: 2019-12-19)
INTRODUCCIÓN: Este estudio evalúa el aumento selectivo de la conductividad hepática mediante la infusión hipersalina en el sistema portomesentérico para tratar simultáneamente todos los tumores hepáticos mediante electroporación ...
Campos, Maria Luisa Morais Sarmento de (Date of defense: 2010-04-09)
Ptf1a/p48 is a pancreas specific bHLH transcription factor that is required at early stages of embryonic development for pancreas formation and, during adulthood, for the proper exocrine pancreatic function. P48 also exerts ...
Margalef González, Pol (Date of defense: 2014-02-17)
L’IKKα nuclear regula la transcripció gènica i ha estat relacionada amb la progressió del càncer i la metàstasis, tot i que la connexió mecanística no s’entén massa bé. Hem observat que les ...
Barriga de Vicente, Francisco Martín (Date of defense: 2013-11-28)
The first chapter of this thesis describes the study of intestinal stem cells (ISCs) and their relationship to colon cancer. We describe the transcriptional landscape of intestinal epithelial populations through the use ...
Garcia Rodríguez, Laura (Date of defense: 2008-06-26)
L'adenocarcinoma ductal de pàncrees és un càncer molt agressiu que actualment representa la quarta causa de mort per càncer als països occidentals. Les teràpies clàssiques, basades en la resecció quirúrgica, la radioteràpia ...
Dumbović, Gabrijela (Date of defense: 2017-01-12)
DNA hypomethylation of repeats has been found in almost every tumor type studied. Hypomethylation of repetitive elements was shown to increase the likelihood of homologous recombination of these repeated sequences and thus ...
Haya Hidalgo, Jenny Rosario (Date of defense: 2018-12-19)
To date, there are scarce data on bowel dysfunction (BD) in patients after brain injury (BI). Until now, only fecal incontinence (FI) has received attention and it has been mainly associated to patients’ age or performance ...
Jakszyn, Paula (Date of defense: 2006-10-02)
La evidencia sobre el efecto de las nitrosaminas (NA) sobre el cáncer gástrico (CG) es insuficiente. El objetivo fue evaluar el efecto de las NA (exógenas y endógenas ) y sus alimentos fuente sobre el riesgo de CG. El ...
López Arribillaga, Erika (Date of defense: 2016-06-17)
Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally in this context ...
Willis, Jesse (Date of defense: 2021-11-18)
Microbiome studies have burgeoned in the last few decades, largely thanks to the innovations in high throughput sequencing, affording researchers the opportunity to categorize nearly the entirety of the microbial population ...