Caracterització dels receptors de l'activador tissular del plasminogen (tPA) en càncer de pàncrees 

    Roda Noguera, Oriol (Date of defense: 2006-05-30)

    El càncer de pàncrees és altament agressiu i representa la cinquena causa de mort al mon occidental. Anteriorment, en el nostre laboratori, vam identificar que el receptor tissular del plasminogen (tPA) hi està sobre-expressat ...

    Characterization of SF3B1 mutation in chronic lymphocytic leukemia and the role of new splicing modulators 

    López Oreja, Irene (Date of defense: 2022-03-01)

    Mutations in Splicing Factor 3b Subunit 1(SF3B1) are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with worse disease prognosis. SF3B1 is involved in pre-mRNA splicing and is the ...

    Chromatin alterations imposed by the oncogenic transcription factor PML-RAR 

    Morey Ramonell, Lluís (Date of defense: 2008-02-01)

    En mamíferos, así como en plantas, mutaciones en AND helicasas/ATPasas del la família SNF2, no solo afectan a la estructura de la cromatina, sino que también afectan al patrón global de la metilación del ADN. Sugiriendo ...

    Creating the AML-specific t(9;11) chromosomal translocation model to study the structural basis of leukemia development in mouse cells 

    Sparavier, Aleksandra (Date of defense: 2022-06-03)

    Chromosomal translocation are large-scale genome rearrangements found in several cancers. They are formed when two (or more) non-homologous chromosomes interchange large parts as a result of erroneous DNA repair after ...

    Effect of hormone disruptors on birth outcomes and child's anogenital distance 

    Vafeiadi, Marina (Date of defense: 2014-02-26)

    Introduction: Persistent Organic Pollutants (POPs) include a wide range of synthetic chemical substances that are ubiquitous in the environment and are identified as endocrine disrupting chemicals (EDCs) which can alter ...

    Estrategias para la diferenciación in vitro de células ES de ratón a células acinares pancreáticas 

    Rovira Clusellas, Meritxell (Date of defense: 2007-01-31)

    Las patologías más importantes del páncreas exocrino, como la pancreatitis crónica (PC) o el cáncer de páncreas, representan un gran problema de salud pública en Europa. En la PC, el tejido acinar es substituido por complejos ...

    The Evolution of T-cell acute lymphoblastic leukemia in adult patients under treatment 

    Sentís Carreras, Inés (Date of defense: 2021-01-22)

    Acute lymphoblastic leukemia (ALL) is a blood cancer characterized by a high proliferation and maturation arrest of the lymphoid precursors which can either be from B or T-cell lineage. In adult patients, this type of ...

    Improving molecular diagnosis in myeloid neoplasms : The role of cell-free DNA 

    García Gisbert, Nieves (Date of defense: 2022-03-04)

    Myeloid malignancies are clonal diseases originated in myeloid hematopoietic stem cells that are frequently initiated by somatic mutations. The detection of genetic alterations has considerably improved the diagnostic ...

    A physician-in-the-loop approach by means of machine learning for the diagnosis of lymphocytosis in the clinical laboratory 

    Bigorra López, Laura (Date of defense: 2022-04-08)

    The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...

    Regulatory mechanisms of c-Myc and their role in Acute Myeloid Leukemia 

    Uribesalgo Micàs, Iris (Date of defense: 2010-11-24)

    The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms restrain the oncogenic ...

    Role of epigenetic modifications in acute promyelocytic leukemia 

    Villa, Raffaella (Date of defense: 2007-12-10)

    Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...

    Socioeconomic inequalities in type 2 diabetes mellitus in Europe 

    Espelt Hernández, Albert (Date of defense: 2011-11-28)

    Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide. The St. Vincent declaration emphasized the urgent need to improve the epidemiological knowledge of this disease in Europe. Within Europe, research ...

    SRRM3 regulates a subprogram of highly sensitive microexons important for pancreatic endocrine function 

    Bajew, Simon (Date of defense: 2022-04-12)

    Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This Thesis focuses on ...

    The Role of PHF19 in myeloid leukemia 

    García Montolío, Marc (Date of defense: 2019-10-31)

    Polycomb group (PcG) of proteins are a group of highly conserved epigenetic regulators involved in many biological functions such as embryonic development, stem cell self-renewal, cell proliferation, and cancer. PHD finger ...