Cellular senescence in skeletal muscle regeneration, ageing and disease 

    Moiseeva, Victoria (Date of defense: 2022-07-22)

    Este proyecto se centra en el papel de las células senescentes durante la regeneración muscular desde varios ángulos. Para llevarlo a cabo, hemos desarrollado una técnica novedosa para poder aislar células senescentes ...

    Construction of injectable wireless microstimulators based on rectification of volume conducted high frequency currents 

    García-Moreno, Aracelys (Date of defense: 2022-03-01)

    Functional neuromuscular stimulation (FNS) refers to the delivery of electrical stimuli to nerves or muscles to enhance, modify or restore motor functions. Despite their invasiveness, implantable systems for FNS offer ...

    Delineating a requirement for Survival of Motor Neuron (SMN) protein in skeletal muscle tissue 

    Faleiro, Michelle R. (Date of defense: 2017-03-27)

    Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of the lower motor neurons. It is caused by homozygous loss or mutations in the Survival Motor Neuron 1 (SMN1) ...

    Disfunció Muscular en Malalts amb malaltia Pulmonar Obstructiva Crònica (MPOC) 

    Coronell Coronell, Carlos Gustavo (Date of defense: 2006-03-02)

    La Enfermedad Pulmonar Obstructiva Crónica (EPOC), presenta signos y síntomas sistémicos que se han venido explorando desde hace algún tiempo. La presente Tesis Doctoral estudia la disfunción que presentan los músculos ...

    Disuse muscle atrophy and cachexia : a step forward on muscle regeneration and therapeutic opportunities 

    Mañas García, Laura (Date of defense: 2021-03-02)

    La atrofia muscular por desuso en el contexto de las enfermedades crónicas, como enfermedades respiratorias, cáncer o un reposo prolongado, se caracteriza por la pérdida de masa y función muscular. Además, el desgaste ...

    Estrategias terapéuticas en un modelo experimental de caquexia cancerosa : efectos de los polifenoles curcumina y resveratol 

    Penedo Vázquez, Antonio (Date of defense: 2021-11-26)

    La caquexia es un síndrome metabólico complejo asociado con enfermedades crónicas como el cáncer, se caracteriza por una atrofia progresiva del músculo esquelético que conduce a una disminución del peso corporal, inicia ...

    Estructura, biología y función muscular esquelética en mujeres con EPOC 

    Ausín Herrero, Pilar (Date of defense: 2016-01-25)

    La disfunción muscular es una importante afectación sistémica en la EPOC, con un origen multifactorial e impacto en la actividad física, capacidad de ejercicio, calidad de vida y mortalidad de los pacientes. Hasta el momento ...

    Estudio en poblaciones seleccionadas de la fiabilidad de nuevos protocolos de detección de consumo de hormonas recombinantes (hgH y EPO) 

    Abellán Sánchez, María Rosario (Date of defense: 2006-07-07)

    Las hormonas recombinantes eritropoyetina (EPO) y hormona de crecimiento (GH), prácticamente iguales a las endógenas y de corta vida media en circulación, son de difícil detección directa en el control antidopaje. <br/>Se ...

    Factores pronósticos en el latigazo cervical 

    Pleguezuelos Cobo, Eulogio (Date of defense: 2011-12-12)

    Múltiples revisiones científicas han intentado determinar los factores pronósticos en la evolución del latigazo cervical sin llegar a un consenso. Nuestros resultados se han obtenido tras 8 años de estudio en ...

    Musculoskeletal side effects of aromatase inhibitors treatment in women with breast cancer 

    Rodríguez Sanz, Maria (Date of defense: 2016-12-15)

    New high-throughput behavioral systems enable the recording of continuous behavioral sequences with an unprecedented richness of signals and a deep temporal resolution. Automated systems offer neuroscience the opportunity ...

    Prevention and management of musculoskeletal pain at work in nursing staff : Design, implementation and evaluation of a multifaceted intervention in the workplace 

    Soler-Font, Mercè (Date of defense: 2021-07-08)

    Objectiu: Dissenyar, implementar i avaluar una intervenció multifacètica en el lloc de treball per prevenir i gestionar el dolor musculoesquelètic (DME). Mètodes: Es va dissenyar, implementar i avaluar (efectivitat, procés ...

    Role of brain-muscle circadian clock communication in skeletal muscle homeostasis and aging 

    Vaca Dempere, Mireia (Date of defense: 2022-07-21)

    Daily time-keeping of tissue functions promotes efficient organ function and systemic metabolic homeostasis, processes integral to life which are subject to decline with aging. To ensure the correct functional coordination ...

    Role of psychological and culturaly influenced risk factors on symptoms and disability for musculoskeletal disorders. CUPID study (Spain) 

    Vargas-Prada Figueroa, Sergio (Date of defense: 2014-01-24)

    This PhD thesis is based on the Spanish sample of the International “Cultural and Psychosocial Influences on Disability” (CUPID) study. This multicentre study is coordinated by Professor David Coggon at the University of ...

    Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain 

    Carcolé Estrada, Mireia (Date of defense: 2019-12-05)

    Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited ...

    Sarcopenia: replanteando las estrategias en el abordaje diagnóstico y terapéutico 

    Meza de Valderrama, Delky (Date of defense: 2022-11-29)

    La presente tesis doctoral se basa en el compendio de tres estudios de investigación, que tenían como objetivo evaluar: (1) la factibilidad y la fiabilidad de la medición del grosor del músculo del antebrazo (MT), (2) los ...

    Skeletal muscle aging: stem cell function and tissue homeostasis 

    Victor, Pedro Sousa (Date of defense: 2012-02-27)

    Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in geriatric individuals undergoing sarcopenia. The age-associated muscle wasting is also associated ...

    The fibrinolitys system in muscle regeneration and dystrophy 

    Vidal Iglesias, Berta (Date of defense: 2008-09-17)

    Duchenne muscular dystrophy (DMD) is a fatal degenerative disorder of locomotor and respiratory muscles, in which myofibers are progressively replaced by non-muscular fibrotic tissue. Here, we show that fibrin/ogen accumulates ...

    The regulatory roles of MicroRNAs in bone remodeling and osteoporosis 

    Ugarte Corbalán, Laura de (Date of defense: 2016-12-20)

    In bone field, microRNAs (miRNAs) have been described as key factors regulating bone formation, remodeling, and homeostasis. The identification of miRNAs involved in skeletal function will be essential to the development ...

    The Role of histone variant macroH2A1 in muscle physiology and pathophysiology 

    Posavec, Melanija (Date of defense: 2014-06-17)

    MacroH2A1.1 is one of the least understood histone variants and structural components of chromatin. Generated by alternative splicing, macroH2A1.1 differs from the other macroH2A1 isoform in its capacity to bind NAD+-derived ...