Millán Ariño, Lluís (Date of defense: 2013-11-25)
Seven linker histone H1 variants exist in human somatic cells with distinct prevalence among cell types and during differentiation. Despite being key chromatin structural components, it remains elusive ...
Timón Pérez, Krystal (Date of defense: 2018-12-18)
During mitosis, the microtubules organize a bipolar spindle that segregates the chromosomes. In higher eukaryotes, these microtubules are nucleated through three different pathways involving the centrosomes ...
Pazo Pelegrí, Esther (Date of defense: 2021-07-15)
At the end of G1 phase, cells have to decide between continue proliferation or remain in a quiescent state (G0). This decision point, known as “Start” in yeast and “Restriction Point” in metazoans, marks ...
Krüger, Angela (Date of defense: 2012-12-14)
The embryo of Caenorhabditis elegans is a model system in which development can be studied at single cell resolution. In this thesis I describe the use of a semi-automatic nuclear tracking algorithm to ...
Alberdi Ibarzabal, Maria (Date of defense: 2015-07-24)
CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described ...
Delaspre, Fabien (Date of defense: 2011-02-04)
Tot i que es coneix l’involucrament de les cèl·lules pancreàtiques acinars en patologies exocrines (pancreatitis i càncer de pàncrees), la manca de models normals basats en cèl·lules ha limitat ...
Maier, Michael (Date of defense: 2017-03-30)
Successful chromosome segregation is crucial for the survival of a cell and to avoid diseases such as cancer. Anaphase bridges are a type of segregation defect that can arises from structurally compromised ...
Canal de Torres, Berta (Date of defense: 2018-02-16)
In response to multiple internal and external stresses, yeast cells activate a common transcriptional response known as the Environmental Stress Response (ESR), which can be problematic in S phase, when ...
Aparicio i Prat, Estel (Date of defense: 2014-02-07)
Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT ...
Cavazza, Tommaso (Date of defense: 2015-10-30)
To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle ...