Mostrando ítems 1-10 de 18
Rodríguez Galindo, Miguel (Fecha de defensa: 2023-11-13)
Tumor progression is dominated by two evolutionary forces: first mutagenesis, which provides the heritable variability where, secondly, natural selection acts. The main challenge of cancer genomics is ...
Schroeder, Michael Philipp (Fecha de defensa: 2014-11-21)
Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation ...
Singh, Babita (Fecha de defensa: 2017-05-11)
RNA processing and their alterations are determinant to understand normal and disease cell phenotypes. In particular, specific alterations in the RNA processing of genes has been linked to widely accepted ...
Elosua-Bayés, Marc (Fecha de defensa: 2023-06-08)
Understanding multicellular organisms depends on the advent of technologies capable of delivering unprecedented levels of resolution. With new technologies come novel data modalities, which require ...
Caballero de la Torre, María (Fecha de defensa: 2021-09-09)
Retinoblastoma protein (RB) is a negative regulator of the cell cycle. In response to environmental stress, p38 MAPK phosphorylates RB in the N-terminal region, increasing the affinity of RB for E2F, ...
Bosch de Basea i Gómez, Magda (Fecha de defensa: 2016-11-28)
The present thesis introduces the EPI-CT cohort study; a European collaborative effort aimed at quantifying the health risks of computed tomography (CT scan) radiation exposure during childhood and ...
Sala Romanyà, Laura (Fecha de defensa: 2018-06-20)
Snail1 is a transcription factor which activity is required for the fibroblasts-to-myofibroblast differentiation. In the first part of the thesis we characterize a protein complex involving Snail1, PRMT1 ...
Rubio Pérez, Carlota (Fecha de defensa: 2017-11-28)
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other ...
Vali Pour Jamnani, Mischan (Fecha de defensa: 2022-06-02)
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences ...
Güney, Emre (Fecha de defensa: 2012-09-25)
The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a ...