Hoffmann, Tobias (Date of defense: 2021-04-08)
The splicing regulatory protein RBM10 is frequently mutated in bladder carcinomas. Analysis of RNA sequencing data of 476 bladder tumours (UROMOL) identified 469 alternative splicing (AS) events ...
Rodríguez Sodupe, Pau (Date of defense: 2022-03-09)
The profiling of circulating-tumor DNA (ctDNA) in blood plasma, often known as liquid biopsy, has recently been of great interest in cancer research. This minimally-invasive strategy relies on the fact ...
Inglés Ferrándiz, Marta (Date of defense: 2018-12-14)
In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different ...
Mina Ibarra, Leonardo Bruno (Date of defense: 2010-05-21)
The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides ...
Cornet Bartolomé, Carles (Date of defense: 2020-01-17)
High drug attrition rate during clinical and post market phases is one of the major factors contributing to the pharmaceutical industry productivity crisis. This problem is especially worrisome in the ...
Alba Castellón, Lorena (Date of defense: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...
Frigola Rissech, Joan (Date of defense: 2020-03-13)
The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational ...
Herrero Vicente, Jorge (Date of defense: 2024-02-26)
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible ...
Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Besedina, Elizaveta (Date of defense: 2023-05-12)
Determinar qué genes están bajo selección durante la evolución del cáncer puede explicar cómo se forman y progresan los tumores, y sugerir nuevos objetivos terapéuticos. Sin embargo, la detección de ...