Recent Submissions

Dinámica clonal en las neoplasias mieloproliferativas crónicas 

Fernández Ibarrondo, Lierni (Date of defense: 2024-04-05)

Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones driver que afectan a la vía JAK/STAT. ...

Precise writing of human genomes: engineering & characterizing genome editors for programmable DNA integration in human cells 

Ivancic, Dimitrie (Date of defense: 2024-04-03)

Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome editors has enabled ...

Neural entrainment to languages of different rhythms in adults and infants 

Özer, Ege Ekin (Date of defense: 2024-03-21)

In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. In two experimental ...

Analysis of circulating RNAs for the early detection of complex diseases using liquid biopsy 

Cabús Fornas, Lluc (Date of defense: 2024-03-15)

RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as a noninvasive biomarker ...

Dissecting γTuRC recruitment and microtubule nucleation at MTOCs 

Vineethakumari Muraleedharan, Chithran (Date of defense: 2024-03-14)

Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting the formation of ...

Bilingual insights into the initial lexicon: the role of cognates in word acquisition 

García de Castro García, Gonzalo (Date of defense: 2024-03-11)

Bilingual infants acquire words at a similar rate as monolingual ones, despite navigating a more intricate linguistic environment. The mechanisms behind this phenomenon remain elusive. Our project addressed the potential ...

Dietary palmitic acid estabishes an epigenetic memory that promotes metastasis: Implications of neural-related processes in enhacing dissemination 

Domínguez Rodríguez, Diana (Date of defense: 2021-05-04)

La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars. Investigacions anteriors del nostre laboratori han demostrat la importància ...

Genetically engineering living systems: From complex computational scenarios to multiple market applications 

Mogas Diez, Sira (Date of defense: 2022-01-28)

This PhD thesis explores the potential embedded in living organisms, understood as highly complex machines which can sense, compute, and react to changes in their surroundings. From this general idea, we have made use of ...

Cognitive and synaptic outcomes of targeting peripheral cannabinoid type-1 receptor: focus on naïve and intellectual disability mouse models 

Bergadà Martínez, Araceli (Date of defense: 2024-03-08)

Cognition is a physiological brain function that refers to the process of acquiring and managing knowledge and understanding. It embraces multiple domains, including memory. Intellectual disability disorders such as fragile ...

Understanding and targeting mitochondria to counteract cellular senescene: elucidation of novel senotherapies 

López Polo, Vanessa (Date of defense: 2024-03-07)

The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the adaptations in the ...

Role of polycomb-like proteins in mouse embryonic stem cell differentiation 

Condemi, Livia (Date of defense: 2024-03-07)

Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...

Uso de los cambios en el soporte ventilatorio no invasivo durante la insuficiencia respiratoria aguda hipoxémica 

Parrilla Gómez, Francisco (Date of defense: 2024-03-01)

El soporte respiratorio no invasivo (SRNI) es utilizado ampliamente en los Servicios de Medicina Intensiva para el tratamiento de la Insuficiencia Respiratoria Aguda Hipoxémica (IRAH). A pesar de los múltiples estudios ...

Demographic inference in complex populations: the North African case 

Serradell Noguera, Jose Miguel (Date of defense: 2024-03-01)

Since the first peopling of the region, multiple demographic events have occurred generating a complex genetic landscape in North Africa characterized by high genetic heterogeneity and constant gene flow from surrounding ...

Uncertainty analysis of individual predictions and integrated safety assessments in toxicology 

Kopańska, Karolina (Date of defense: 2024-02-29)

The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the- art ...

Inhaled treatment and patient-reported outcomes in asthma 

Lizano-Barrantes, Catalina (Date of defense: 2024-02-29)

The general aim of this doctoral thesis was to examine the impact on persons with persistent asthma of inhaled treatment use and sociodemographic factors, in terms of patient-reported outcomes. To achieve this, a new ...

Characterization of synthetic lethality between MYC activation and splicing inhibition in an immortalized cell line : roles of alternative splicing 

Herrero Vicente, Jorge (Date of defense: 2024-02-26)

Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...

The Hajar Mountains of Southeastern Arabia: a laboratory to understand how reptile diversity is generated, distributed and maintained in arid environments 

Burriel Carranza, Bernat (Date of defense: 2024-02-26)

This thesis provides new insights into the evolution of biodiversity in arid regions by exploring the patterns and drivers of reptile diversity in the Hajar Mountains of Southeastern Arabia. We first assemble a genomic ...

Exploring the frontiers of synthetic biology: modelling, characterization, and applications of genetics circuits 

González i Colell, Marc (Date of defense: 2024-02-23)

Engineering biology requires a clear set of rules that ensure design predictability. However, certain biological processes difficult the application of these rules, impairing prediction. In the first section of this PhD ...

The price of deciding: balancing resource constraints for optimisation 

Vidal, Alice (Date of defense: 2024-02-23)

Prendre decisions es un repte, i a la par un aspecte inevitable a les nostres vides. D’entre totes les opcions viables, hom ha de sotmetre a escrutini i avaluació les diverses alternatives en tant gestionant la frustració ...

Adaptations in cancer: a molecular and mechanistic rewiring 

Ghose, Ritobrata (Date of defense: 2024-02-02)

Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...