Departament de Medicina i Ciències de la Vida

Inclou totes les tesis d'aquest departament, incloses les anteriors al curs 2021-22, quan tenia el nom Departament de Ciències Experimentals i de la Salut


Si sou doctor o doctora de la Universitat Pompeu Fabra i voleu publicar la vostra tesi a TDX, contacteu amb tdx@upf.edu. Per a més informació consulteu Publicació de tesis a TDX. i les preguntes més freqüents

Recent Submissions

Saludables i equitatives : disseny i avaluació d'intervencions socioeducatives de promoció de les relacions saludables i equitatives en contextos d'educació formal 

Forcadell i Díez, Lluís (Date of defense: 2023-12-21)

Les relacions de poder, que són hegemòniques a la nostra societat, causen i perpetuen les iniquitats socials, fent ús de les violències per sostenir les asimetries i afectant negativament a la salut física, mental i social ...

The tumor-supressive role of RNF144B: a p53-activated E3 ligase guarding genomic stability 

Abad Cortel, Etna (Date of defense: 2023-12-13)

El conegut supressor tumoral p53 regula un ampli programa transcripcional que protegeix envers el càncer. No obstant, la complexitat d’aquest programa fa difícil determinar el rol de cada gen regulat per p53. Deplecionar ...

Sleep in the preclinical stages of Alzheimer's disease: a multimodal biomarkers approach 

Stankeviciute, Laura (Date of defense: 2023-12-12)

This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. ...

Work trajectories after a sickness absence due to cancer in Catalonia (Spain) 

Ayala García, Amaya (Date of defense: 2023-12-04)

The project focuses on cancer and its effects on work trajectories from a life course perspective, both from a qualitative and quantitative approach. Quantitative analyses were based on a retrospective dynamic cohort of ...

NKG2A blockade as a potential strategy to improve NK cell-mediated ADCC in HER2+ breast cancer 

Suárez Olmos, Jesús (Date of defense: 2023-11-30)

Several studies support the contribution of antibody-dependent NK cell cytotoxicity (ADCC) to the clinical efficacy of anti-HER2 therapeutic antibodies in HER2-positive breast cancer. Novel anti-HER2 antibody drug conjugates ...

De novo genome assemblies of endagered species and challenging chromosomes 

Palmada Flores, Marc (Date of defense: 2023-11-27)

Modern biology relies on genomic references to perform analyses in most studies. High-quality de novo genome assemblies are key to having references containing all the genomic content of a species. Here I use avant-garde ...

Detection of selection signals on regulatory units across human cancers 

Rodríguez Galindo, Miguel (Date of defense: 2023-11-13)

Tumor progression is dominated by two evolutionary forces: first mutagenesis, which provides the heritable variability where, secondly, natural selection acts. The main challenge of cancer genomics is to identify the somatic ...

Computational studies of DNA damage and repair of alkylating agents and UV light 

Kranas, Hanna (Date of defense: 2023-11-03)

Living cells are exposed to naturally occurring DNA-damaging agents that promote the loss of genome integrity, threatening the proper functioning of the cell. To counteract the toxic accumulation of DNA damage, organisms ...

Predicting effects of stroke lesions and recovery through whole-brain modeling and brain dynamics 

Idesis, Sebastian Ariel (Date of defense: 2023-11-03)

Stroke is the second leading cause of death worldwide and a major contributor to disability. However, our understanding of the consequences of stroke lesions remains limited, relying mainly on behavioral reports and ...

Molecular mechanisms during the differentiation, maturation and function of marine fish spermatozoa 

Castro Arnau, Júlia (Date of defense: 2023-10-23)

The molecular mechanisms regulating sperm differentiation (spermiogenesis) and maturation in fishes are largely unknown. In these oviparous species, the initiation of sperm motility is triggered by the osmolality of the ...

On the flexibility of the perception and cognition of broken harmonic expectations 

Pagès-Portabella, Carlota (Date of defense: 2023-10-19)

La música està present en totes les cultures. Tot i tenir les mateixes habilitats auditives, la manera en la què experimentem la música depèn del context cultural, la música que escoltem en el dia a dia o si hem rebut ...

Diversity and evolution of South Pacific Eumolpinae (Coleoptera: Chrysomelidae) and the role of New Caledonia in their diversification 

Platania, Leonardo (Date of defense: 2023-10-11)

The South Pacific is an intriguing region for studying evolutionary biology, presenting an exceptional diversity and complex geological and environmental characteristics. New Caledonia, in particular, hosts a rich and ...

Lifestyle interventions and cognitive change: determinants and underlying mechanisms 

Soldevila Domènech, Natàlia (Date of defense: 2023-10-05)

Les intervencions que milloren l’estil de vida (dieta, exercici físic i entrenament cognitiu) poden frenar el declivi cognitiu en persones a risc de demència. En el context d’intervencions en l’estil de vida, aquesta ...

Computational egineering of biomolecules 

Cianferoni, Damiano (Date of defense: 2023-10-09)

Aquesta tesi presenta diversos avenços que inclouen: (i) noves funcionalitats afegides a la “suite” d'eines de disseny de proteïnes FoldX per permetre als usuaris treballar amb qualsevol tipus de molècula; (ii) estudis ...

Deciphering the nuclear function of folate enzyme MTHFD2 in cancer: a novel role for nuclear MTHFD2 in mitosis 

Pardo Lorente, Natalia (Date of defense: 2023-10-06)

Subcellular compartmentalisation of metabolic enzymes may elicit specific cellular functions by establishing a unique metabolic environment. Indeed, the nuclear translocation of certain metabolic enzymes impacts epigenetics ...

Dynamics of cellular decision making in embryogenesis 

Torregrosa Cortés, Gabriel (Date of defense: 2023-09-29)

This thesis is about development and its study from a theoretical point of view, with special interest in how to describe development as a dynamical systems' problem. The thesis digs into four directions embedded in this ...

Uncovering novel vulnerabilities of melanoma cells based on RNA regulation 

Mestre Farràs, Neus (Date of defense: 2021-09-16)

La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten o inhibeixen la ...

Polycomb repressive complex 2 deregulation in tissue homeostasis and cancer 

Espejo Díaz, María Isabel (Date of defense: 2021-09-20)

Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic lethality and disease, ...

Human population genetics of North Africa: insights into demography and functional variation 

Lucas-Sánchez, Marcel (Date of defense: 2023-09-18)

Since the origins of humankind, North Africa has been involved in many demographic events, leading to a heterogeneous cultural and genetic landscape. However, it is largely underrepresented in genetic studies, and many ...

The role of the expanded endocannabinoid system in cognitive impairments induced by prenatal and lactation alcohol exposure in mice 

García Baos, Alba (Date of defense: 2023-09-13)

Alcohol exposure during gestation and lactation leads to physical and behavioral disabilities known as fetal alcohol spectrum disorder. Although cognitive dysfunction is highly frequent and compromises the patients’ quality ...

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