Browsing Departament de Ciències Experimentals i de la Salut by titles

Native American genetic history through admixed populations of Brazil

Mas Sandoval, Àlex, 1989- (Date of defense: 30-11-2018)

Most of the Native American populations that lived in nowadays Eastern Brazil when the Europeans established in the area in the 16th century do not exist anymore. The colonization of Brazil implied huge migrations from ...

Natural antisense transcripts control LEF1 gene expression

Aparicio i Prat, Estel, 1986- (Date of defense: 07-02-2014)

Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT is transcribed from a ...

Natural outdoor environments and adults' health : associations, effect modifiers and mediators

Triguero Mas, Margarita, 1985- (Date of defense: 14-02-2017)

This thesis aims at (a) evaluating the association between natural outdoor environments (NOE) and health in adults and potential effect modifiers of this association, and (b) investigating the possible mechanism of this ...

Neural correlates of memory impairment and rescue in a mouse model of Down syndrome

Alemany González, Maria, 1991- (Date of defense: 09-07-2019)

Understanding the neural correlates of intellectual disability is still a central and unresolved problem in neuroscience. Here we have unravelled several candidate neural substrates of memory impairment and rescue using a ...

Neural map organization and development in the lateral-line system

Pujol Martí, Jesús (Date of defense: 02-03-2012)

Les neurones sensorials projecten al sistema nerviós central seguint una distribució espacial ordenada, formant mapes neuronals que representen propietats dels estímuls sensorials i que són considerats essencials per a ...

Neural mechanisms of abstract rule changes in speech : exploring phonologic and attentional constraints

Monte Ordoño, Julia, 1989- (Date of defense: 13-04-2018)

L’extracció de regles de la parla és crucial per a l’adquisició del llenguatge. La present dissertació estudia el mecanisme d’aprenentatge de regles explorant com el cervell detecta regularitats rellevants dins del senyal ...

Neural networks connecting emotion and cognition assessed in psychopaths, cocaine users and obsessive-compulsive disorder using MRI

Contreras Rodríguez, Oren, 1985- (Date of defense: 12-09-2013)

Emotional processing is fundamental for normal socialization, interpersonal interactions, successful decision-making and overall to self-regulate behavior according to each context. Adequate emotional processing relies ...

Neurobiological correlates of behavioural alterations in mouse models of MBNL2 deficiency and pharmacological interventions : relevance for myotonic dystrophy type 1

Ramon Duaso, Carla, 1987- (Date of defense: 16-12-2019)

Myotonic dystrophy type 1 (DM1) is a rare disease characterized by muscular defects, as well as, cognitive and mood alterations. Although these neurophysiological disturbances are very debilitating, there is lack of data ...

Neurobiological links between depression and drug dependence

Gracia Rubio, Irene, 1986- (Date of defense: 15-03-2016)

Early life experiences play a key role in brain function and behaviour. Maternal separation produced negative early life experiences that induce emotional alterations. Contrary, the communal nest has been proposed as a ...

Neurobiological mechanisms involved in chronic pain

Negrete Buela, Roger (Date of defense: 16-12-2016)

Chronic pain is currently a major clinical issue that represents huge economic and social burdens. Chronic pain treatment currently available presents limited efficacy and significant side effects. One of the reasons for ...

Neurobiological mechanisms involved in MDMA-Seeking behaviour and relapse

Orejarena, Maria Juliana

(+) 3,4-metilendioximetanfetamina (MDMA), popularmente conocida como "éxtasis", es una droga susceptible de producir adicción en algunos individuos. Actualmente es consumida principalmente por adolescentes y jóvenes. Los ...

Neurobiological mechanisms involved in memory function and dysfunction : focus on the endocannabinoid system and associated system and associated signaling pathways

Gomis González, Maria, 1988- (Date of defense: 08-11-2017)

Memory is a complex brain function that constitutes a crucial feature of individuals. Understanding the precise neurobiological mechanisms involved is a fundamental challenge in Neuroscience, where multiple brain areas and ...

Neurobiological substrates involved in the behavioural alterations induced by MDMA and THC administration in mice

Viñals Álvarez, Xavier, 1985- (Date of defense: 09-04-2015)

El cànnabis i l’èxtasi són dues drogues d’ús recreatiu, les quals usualment es solen consumir de forma conjunta. Degut al seu ús combinat, resulta difícil esclarir les conseqüències que té cada droga a nivell neurobiològic. ...

Neuroendocrine control of puberty in vertebrates : characteriization of the kisspeptin system in flatfish

Mechaly, Alejandro S. (Date of defense: 27-06-2011)

The recently discovered decapeptide kisspeptin and its G-protein coupled receptor form a signaling system expressed ubiquitously and are implicated in a variety of still poorly characterized functions. In the brain, ...

Neurogenic bowel dysfunction in subjects with brain injury : prevalence, risk factors, clinical characterization and physiopathology

Haya Hidalgo, Jenny Rosario, 1978- (Date of defense: 19-12-2018)

To date, there are scarce data on bowel dysfunction (BD) in patients after brain injury (BI). Until now, only fecal incontinence (FI) has received attention and it has been mainly associated to patients’ age or performance ...

Neuroplasticity-targeted therapy for Down syndrome: a translational approach

Catuara Solarz, Silvina, 1986- (Date of defense: 16-09-2016)

This Thesis aims at addressing the therapeutic potential of a neuroplasticity-targeted treatment for intellectual disability (ID) in Down syndrome (DS). The therapy consisted of the administration of the green tea catechin ...

Neuroprotective mechanisms of CB2 cannabinoid receptors and PPAR-α in hypoxia/ischemia-induced brain damage

Kossatz de Mello, Elk, 1977- (Date of defense: 08-06-2018)

In this thesis, we have developed a hypoxia-ischemia (HI) model in adult mice to study the neuroprotective mechanisms of CB2 cannabinoid receptors (CB2R), and the potential therapeutic effects of the new PPAR-α agonist, ...

Neuropsychological profile of Williams-Beuren syndrome and genetic modulators

Pérez García, Débora, 1985- (Date of defense: 16-11-2015)

Williams-Beuren syndrome is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes in 7q11.23. Despite the great advances on the knowledge of the clinical phenotype and the molecular causes of the ...

New animals models to evaluate therapeutic targets for pain, cognitive and eating disorders

Bura, S. Andreea (Date of defense: 23-09-2010)

Animal models are crucial to improve the knowledge of the mechanisms underlying the different pathological processes. These models are also excellent tools to facilitate the research of new targets for the treatment of ...

New approaches in omics data modelling

Nonell Mazelon, Lara, 1972- (Date of defense: 19-11-2019)

The breakthrough in the technological field has allowed the extraction of large amounts of the so-called omics data. The analysis and Integration of this type of data by means of advanced statistical and bioinformatics ...

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