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Browsing Departament de Biologia by titles
Now showing items 1-20 of 91
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En aquesta tesi s'han estudiat les propietats antitumorals d'una variant de la ribonucleasa pancreàtica humana anomenada PE5 que incorpora un senyal de localització nuclear. Aquest estudi mostra que PE5 indueix l'apoptosi ...
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(Date of defense: 29-07-2020)Pancreatic Ductal Adenocarcinoma (PDA), the most common pancreatic cancer, remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. Expression ...
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(Date of defense: 20-07-2012)Mammalian spermatozoa acquire functionality during epididymal maturation and ability to penetrate and fertilize the oocyte during capacitation. Sperm quality results indicated that both epididymal maturation and ejaculation ...
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(Date of defense: 19-07-2016)Les ribonucleases són enzims que presenten citotoxicitat selectiva per a cèl·lules tumorals. S'ha proposat l’ús de ribonucleases dirigides a nucli (ND-RNases) com a fàrmacs antitumorals. En aquest treball s'ha caracteritzat ...
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(Date of defense: 17-09-2014)Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these limitations through ...
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El present treball analitza la morfologia espermàtica de l'ejaculat de Sus domesticus, la histologia del conducte epididimari i la qualitat de l'esperma epididimari. El material d'estudi prové de mascles reproductors porcins ...
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(Date of defense: 14-12-2015)The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that ...
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Durant anys, el principal mètode de gestió de les poblacions de truita comuna (Salmo trutta L.) ha estat la repoblació amb exemplars exògens. El seguiment genètic de les poblacions de truita comuna dels Pirineus orientals, ...
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(Date of defense: 15-04-2021)This thesis is aimed at demonstrating a sequential-based approach in detecting an epidemic of chronic diseases in small populations. Especially if commences at some unobserved point. Analyses encompassed registered cases ...
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L'ús d'esperma criopreservada en la inseminació artificial (IA) d'espècies d'interès productiu permet un major control sanitari i la creació de bancs de germoplasma d'alt valor genètic, entre d'altres avantatges. En el ...
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(Date of defense: 17-03-2017)Aquaporins (AQPs) are proteins involved in the transport of water and some other solutes across plasma membranes. The fact that mammalian spermatozoa are highly permeable to water suggests the presence of these proteins. ...
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(Date of defense: 30-09-2016)Boar semen is not collected under sterile conditions,so boar ejaculates are commonly contaminated with a broad range of microorganisms, which may affect sperm quality and lead to a low reproductive performance and severe ...
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(Date of defense: 22-05-2015)Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics de les cèl•lules mare ...
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(Date of defense: 24-07-2012)Ribonucleases are promising candidates for use in anticancer therapy. There are different ways to endow an RNase with antitumor properties. Targeting the enzyme to the cell nucleus is a potential approach. PE5 is a variant ...
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Una soca de Lactobacillus salivarius resistent a la rifampicina, CTC2197, es va assajar com a probiòtic en pollastres, estudiant la seva capacitat de prevenir la colonització de Salmonella enteritidis C-114 en pollastres. ...
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Les dues proteïnes estudiades en aquest treball (ECP o RNasa 3 i RNasa 1ΔN7) pertanyen a la superfamília de la RNasa A i resulten d'especial interès per la seva potencial aplicació en la teràpia i/o diagnòstic del ...
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En aquesta tesi s'ha caracteritzat la ruta d'internalització de l'onconasa, una RNasa citotòxica. Els resultats indiquen que l'onconasa entra a les cèl·lules per la via dependent de clatrina i del complex AP-2. Seguidament ...
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(Date of defense: 02-10-2012)Colorectal Cancer is the main type of cancer in Spain. Up to 90% of the cases are sporadic in nature and its aetiology is still unclear. It is supposed to be a multi-factorial disease, where factors play an important role ...
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(Date of defense: 11-11-2019)Bovine mastitis caused by Streptococcus uberis is a major problem in the dairy industry worldwide. Despite of that, there is no vaccine commercial available against it. Therefore, the objectives of this doctoral thesis are ...
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(Date of defense: 27-06-2018)The blue and red shrimp, Aristeus antennatus, is a commercially important crustacean in the Western Mediterranean Sea and has been listed as a priority species for fishery management. In this thesis, 97 potential and novel ...
Now showing items 1-20 of 91
