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Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines

Cerezo Frias, Vanessa (Date of defense: 2009-05-28)

Els aminoàcids biarílics es troben en una àmplia varietat de pèptids naturals amb important activitat biològica. Concretament, les arilhistidines formen part de les aciculitines, pèptids amb activitat ...

Peptide conjugates containing chlorambucil or tetradentate aminopyridine ligands for anticancer treatment

Soler Vives, Marta (Date of defense: 2015-02-02)

Nowadays, the search for new drugs against cancer is one of the major goals to improve the quality of life of patients. The development of more selective treatments against cancer cells may lead to a ...

Solid-phase synthesis of cell-penetrating γ-peptide/antimicrobial peptide conjugates and of cyclic lipodepsipeptides derived from fengycins

Rosés Subirós, Cristina (Date of defense: 2016-01-22)

This thesis is focused on the development of synthetic approaches to obtain new bioactive peptides. The first part deals with the design of new antimicrobial peptide/cell-penetrating peptide conjugates ...

KSL-W analogues, peptide conjugates and tryptophan-containing cyclic peptides with activity against plant pathogens

Camó Marín, Cristina (Date of defense: 2019-06-27)

Plant diseases produced by bacteria are responsible for considerable economic losses. These phytopathologies are highly contagious and difficult to control. With this aim, we selected peptides reported ...

Disseny i síntesi de lipopèptids cíclics i de pèptids conjugats derivats de BPC194 amb activitat antimicrobiana

Vilà Roura, Sílvia (Date of defense: 2014-07-28)

Les malalties causades per bacteris i fongs són responsables d’importants pèrdues econòmiques en cultius. Es considera que els pèptids antimicrobians, naturals i sintètics, són uns bons candidats per a ...

Synthesis and evaluation of cyclic cationic peptides as antimicrobial agents for use in plant protection

Monroc, Sylvie (Date of defense: 2008-01-18)

Aquesta tesi doctoral se centra en l'estudi de l'aplicació de pèptids antimicrobians en la lluita contra agents patògens de cultius de plantes d'interès econòmic.L'estratègia sintètica s'ha portat a ...

Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana

Afonso Afonso, Ana (Date of defense: 2011-07-22)

En aquesta tesi doctoral es va estudiar la preparació de pèptids biarílics en fase sòlida. En primer lloc, es varen borilar residus de fenilalanina o tirosina presents a la seqüència peptídica a través ...

Synthesis of antimicrobial peptides derived from BP100 and BPC194

Güell Costa, Imma (Date of defense: 2012-01-27)

In the present PhD thesis we studied the solid-phase peptide synthesis of antimicrobial peptides derived from the lead peptides BP100 and BPC194. First, peptides derived from BP100 containing D-amino ...

Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins

Ng Choi, I-teng Montserrat (Date of defense: 2015-12-15)

The incorporation of unsymmetrical biaryl systems into peptide sequences is a strategy that can improve their biological activity. Due to the difficulty of arylating the 4(5}-position of the imidazole ...

Design and synthesis of short antimicrobial peptides for plant protection. Study of their mode of action

Ferre Malagon, Rafael (Date of defense: 2010-07-23)

Aquesta tesi doctoral està basada en el desenvolupament de nous agents antimicrobians derivats del pèptid híbrid cecropina A-melitina WKLFKKILKVL-NH2 (Pep3) que siguin sostenibles i útils per al control ...

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Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines

Peptide conjugates containing chlorambucil or tetradentate aminopyridine ligands for anticancer treatment

Solid-phase synthesis of cell-penetrating γ-peptide/antimicrobial peptide conjugates and of cyclic lipodepsipeptides derived from fengycins

KSL-W analogues, peptide conjugates and tryptophan-containing cyclic peptides with activity against plant pathogens

Disseny i síntesi de lipopèptids cíclics i de pèptids conjugats derivats de BPC194 amb activitat antimicrobiana

Synthesis and evaluation of cyclic cationic peptides as antimicrobial agents for use in plant protection

Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana

Synthesis of antimicrobial peptides derived from BP100 and BPC194

Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins

Design and synthesis of short antimicrobial peptides for plant protection. Study of their mode of action

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