Study of Survival Motor Neuron protein regulation and the role of autophagy in Spinal Muscular Atrophy 

    Periyakaruppiah, Ambika (Date of defense: 2015-06-12)

    Spinal muscular atrophy (SMA) is a genetic disorder caused by loss of the Survival motor neuron 1 gene (SMN1), lead to reduced SMN protein level and selective dysfunction of MNs. SMN reduction causes neurite degeneration ...