Now showing items 423-442 of 457

    Target Therapy in Rhabdomyosarcoma: Discovering new targets and apportunities 

    Prada Varela, Estela Maria (Date of defense: 2021-11-05)

    Pediatric RMS is a developmental tumor that affects patients from birth to late adolescence. RMS tumorigenesis involves the stalk of embryological myogenic processes. Classically, two main subgroups of RMS have been defined ...

    Targeted therapies in CLL. New drugs against CLL recurrent mutations 

    Giménez Carabaza, Neus (Date of defense: 2019-11-15)

    Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western countries. It is currently an incurable disease. CLL is a B-lymphoid neoplasm in which the microenvironment plays a key role in the development ...

    Targeting Malaria Transmission: A Transdisciplinary Approach 

    Portugaliza, Harvie P. (Date of defense: 2020-12-16)

    To achieve malaria elimination, great emphasis must be put on targeting the parasite’s transmissible stages, so that along with effective treatment of clinical malaria caused by asexual stages, complete interruption of the ...

    Targeting the crosstalk between tumor cells and microenvironment: a new therapeutic approach for the treatment of lymphoid neoplasms 

    Vidal Crespo, Anna (Date of defense: 2017-04-28)

    In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable disease where high ...

    Targeting tumor microenvironment crosstalk through GPCR receptors and PI3K pathway 

    Guerrero Hernández, Martina (Date of defense: 2019-02-19)

    The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different ...

    Tatuaje y delincuencia 

    Font Riera, Gabriel (Date of defense: 1971-01-01)

    Por el nacimiento y habitual radicación en las Islas Baleares, y en tanto cursamos los estudios preuniversitarios. permitió que durante varios años llamara poderosamente nuestra atención el observar en innumerables ...

    Temperamento y carácter en trastornos de la conducta alimentaria: correlatos clínicos, psicopatológicos y terapéuticos 

    Agüera, Zaida (Date of defense: 2013-12-12)

    Los Trastornos de la Conducta Alimentaria (TCA) son enfermedades mentales complejas en las que convergen numerosos de factores de riesgo y mantenimiento. La literatura previa pone de relieve la importancia de los rasgos ...

    Teràpia gènica amb hHGF en models de dany renal 

    Franquesa Bartolomé, Marcela (Date of defense: 2010-01-15)

    La isquèmia renal és una de les principals causes del Fracas Renal Agut i en el context del trasplantament renal predisposa l’òrgan a un dany crònic i a una possible pèrdua de l’empelt. La cèl•lula epitelial tubular ...

    The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes 

    Canivell Fusté, Silvia (Date of defense: 2014-10-14)

    The incidence of type 2 diabetes mellitus (T2D) is increasing worldwide. There are several explanations to this fact, such as the increased prevalence of obesity, population’s ageing, and the lack of physical activity ...

    The dynamics of emotional and cognitive networks: Graph-based analysis of brain networks using fMRI and theoretical model for cingulo-frontal network dynamics in major depression 

    Ramírez Mahaluf, Juan Pablo (Date of defense: 2015-05-14)

    This thesis is composed of two complementary projects. One focuses on the study of the dynamics between emotional and cognitive networks in healthy subjects using functional magnetic resonance imaging (fMRI). The second ...

    The epidemiology of diarrhea: Determination of the burden, etiology and consequences of diarrheal disease in children aged 0-59 months in Manhiça District, Mozambique = La epidemiología de las diarreas: Determinación del peso, etiología y secuelas de la enfermedad diarreica en niños de 0-59 meses de edad en el Distrito de Manhiça, Mozambique 

    Nhampossa, Tacilta Helena Francisco (Date of defense: 2013-12-20)

    The objective of this thesis is to improve our understanding of the epidemiology of diarrhea, particularly to estimate the population-based burden, microbiologic etiology and adverse clinical consequences of moderate-to-severe ...

    The possible link between high glucose-induced PKCβ expression and the appearance of GLP-1 resistance in endothelial cells 

    De Nigris, Valeria (Date of defense: 2015-12-03)

    INTRODUCTION. It has been demonstrated that Glucagon-like peptide-1 (GPL-1) has a protective effect on endothelial cells. GLP-1 improves endothelial function in diabetes, however the mechanisms underlying the GLP-1 protective ...

    The role of cyclin-dependent kinase 5 (Cdk5) in colorectal cancer 

    Kjaergaard Bystrup, Sara (Date of defense: 2021-07-20)

    [cat] El càncer colorectal (CCR) és el tercer càncer més freqüent en homes i el segon en dones a nivell mundial. Tot i que les taxes de supervivència a 5 anys en els primers estadis superen el 90%, la situació canvia ...

    The role of RANK pathway in the intestinal epithelium, breast cancer and tumor immune modulation 

    Gómez Aleza, Clara (Date of defense: 2021-10-25)

    [spa] La vía de RANK juega un papel crucial en remodelación ósea, con un anticuerpo monoclonal (denosumab) contra el ligando de la vía de señalización (RANKL), actualmente usado en clínica contra la osteoporosis y efectos ...

    Therapeutic inhibition of PI3K/AKT and WNT/b-catenin pathways in colorectal cancer 

    Arqués Casamitjana, Oriol (Date of defense: 2015-12-04)

    Colorectal cancer (CRC) is a leading cause of death worldwide, especially in the late stages of the disease when relapse and metastasis occur. Despite the improvements achieved recently in terms of treatment and diagnosis, ...

    Tomografia de coherència òptica swept-source com a mètode de valoració de la coroide en les coroiditis estromals primàries 

    Garcia Garcia, Olga (Date of defense: 2017-04-21)

    ANTECEDENTS DEL TEMA: La valoració de la coroides s’ha fet fins el 2005 amb l’angiografia amb verd d’indocianina (AVI), mètode invasiu que requereix l’ injecció d’un contrast per vena antecubital. A partir del 2010, ...

    Toxicitat mitocondrial i hematològica en pacients pediàtrics no infectats, exposats al VIH i a antiretrovirals 

    Rovira Girabal, Núria (Date of defense: 2016-06-21)

    Actualment en el nostre medi només l’1-2% dels fills de mares infectades pel VIH contreuen la infecció, gràcies a les mesures preventives aplicades, fonamentades sobretot en l'ús de fàrmacs antiretrovirals. Malgrat que el ...

    Tracing the developmental history of B-cell tumors by DNA methylation 

    Duran Ferrer, Martí (Date of defense: 2020-11-19)

    The DNA from our cells carries the genetic information to build a human being. This information is interpreted through epigenetic marks that lead to tightly coordinated and cell type-specific gene expression programs. One ...

    Transcatheter Aortic Valve Implantation: Moving Forward to Minimize Vascular and Bleeding Complications = Implante Transcatéter de Válvula Aórtica: Avanzando hacia la Reducción de Complicaciones Vasculares y Hemorrágicas 

    Hernández Enríquez, Marco (Date of defense: 2020-01-23)

    INTRODUCTION: TAVI has settled as the standard of care of AS for inoperable, high-risk, and selected intermediate-risk patients undergoing aortic valve replacement. Vascular and bleeding complications are related to worst ...

    Transposició d’un pedicle adipós pericardíac sobre el miocardi: una nova opció terapèutica per a limitar la cicatriu postinfart 

    Gàlvez Montón, Carolina (Date of defense: 2012-06-26)

    Recentment ha estat demostrada l’existència de cèl.lules progenitores en el greix que envolta el cor. Aquesta nova font cel!lular ha esdevingut una bona alternativa per a regenerar el miocardi infartat. Per aquest motiu, ...