Mostrando ítems 1-10 de 21
Rodríguez-Vida Rodríguez, Alejo (Fecha de defensa: 2017-10-23)
Prostate cancer is the second most frequently diagnosed cancer worldwide and the fifth leading cause of cancer death in men. Despite, the above mentioned incidence and mortality, the existence of a small ...
Roura Fornells, Esther (Fecha de defensa: 2018-10-22)
The objective of this thesis is to estimate prospectively the association between environmental cofactors and the risk of developing cervical cancer and pre-cancer, including tobacco smoking, hormonal ...
Vegliante, Maria Carmela (Fecha de defensa: 2013-09-26)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified ...
Martínez Quetglas, Iris (Fecha de defensa: 2018-01-09)
Insulin-like growth factor (IGF) signaling is frequently altered in HCC, including activation of IGF1R, IGF2 overexpression, IGFBP3 downregulation and IGF2R allelic losses1,2. A previous study from our ...
Recalde-Percaz, Leire (Fecha de defensa: 2021-06-30)
Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with ...
Vidal Crespo, Anna (Fecha de defensa: 2017-04-28)
In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable ...
Moreno Monasterio, Marta (Fecha de defensa: 2015-02-18)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, ...
Cepeda, Edgar B. (Fecha de defensa: 2015-12-18)
CXCR4 is a chemokine receptor originally discovered and cloned in leukocytes that functions by controling the migration to the inflammatory foci. The CXCR4 chemokine receptor and its ligand, SDF-1α (also ...
Sanchez Moral, Lidia (Fecha de defensa: 2019-11-22)
Multiple studies have highlighted the role of ZEB1 as critical regulator of tumor progression through the regulation of different hallmarks of cancer beyond the induction of EMT. The general aim of this ...
Albero Gallego, Robert (Fecha de defensa: 2017-07-21)
Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature B cells characterized by the presence of the t(11;14)(q13;q32) translocation that leads to the overexpression of Cyclin ...