Now showing items 48-67 of 97

    Identificació de microRNAs circulants i placentaris en obesitat materna gestacional i la seva relació amb paràmetres metabòlics materns i el creixement pre i postnatal 

    Bonmatí Santané, Alexandra (Date of defense: 2017-11-28)

    Increased metabolic disease in children is a major public health problem.. Epigenetic marks, such as microRNAs, could be one of the mechanisms that regulate the association maternal obesity with the development of metabolic ...

    Identificación de genes de susceptibilidad en esclerosis múltiple. Descripción clínica y análisis genético de una extensa familia de etnia gitana (Estudio EMGypsy) 

    Robles Cedeño, René (Date of defense: 2016-07-19)

    Multiple sclerosis is a chronic disease of the central nervous system which has an unknown aetiology and an autoimmune mechanism. Two pathogenic processes, inflammation and neurodegeneration, converge causing a progressive ...

    Identificación y caracterización de factores de transcripción implicados en la regulación de procesos moleculares y cerebroreparadores en el ictus 

    Camós Badia, Susanna (Date of defense: 2015-03-27)

    The aim of this thesis was to identify transcriptional regulators involved in the modulation of ischaemia, as well as brain plasticity processes responsible for compensating the ischaemic lesions, in order to establish the ...

    Immunomodulation and metabolism: possible role of lactoferrin 

    Moreno Navarrete, José María (Date of defense: 2011-06-20)

    To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration ...

    Impacte clínic del càlcul de la dosi absorbida en radioteràpia externa mitjançant un nou algorisme basat en la solució de l'equació de Boltzmann 

    Muñoz Montplet, Carles (Date of defense: 2022-03-01)

    The algorithm for calculating absorbed dose in external radiotherapy Acuros XB (AXB), based on the solution of the Boltzmann equation, has shown to achieve a higher level of accuracy than the preceding convolution/superposition ...

    Implicaciones de la adiponectina de alto peso molecular en el eje tiroideo y el metabolismo óseo 

    Prats Puig, Anna (Date of defense: 2012-05-17)

    Adiponectin is a protein secreted by adipose tissue which possesses insulin-sensitivity and anti-atherosclerotic properties. In this work, we will study if high molecular weight adiponectin is a key molecule in the association ...

    Indicació selectiva de "shunt" en l'endoarteriectomia carotídia, un nou mètode 

    Andrés Navarro, Omar (Date of defense: 2020-09-25)

    The protocol followed in this thesis is to indicate the EAC according to the NASCET criteria. Closure of the arteriotomy with patch. The criteria to indicate this have been based on an original method, which takes into ...

    Influencia de la grasa epicárdica en la arritmia: fibrilación auricular, la cardioversión eléctrica, la recurrencia y el tratamiento 

    Valenzuela Leal, Helen (Date of defense: 2019-04-09)

    The thickness of epicartic fat can be directly measured by transthoracic echocardiography. Epicartic fat has recently been associated with the onset of atrial fibrillation (AF). In this work we will analyze the relationship ...

    La proteína C reactiva y la osteocalcina descarboxilada como marcadores de arteriosclerosis preclínica en niños sanos prepuberales 

    Osiniri Kippes, Inés (Date of defense: 2015-07-15)

    La evidencia científica sugiere que la enfermedad arteriosclerótica tiene su origen en edades tempranas de la vida y su progresión está determinada por la suma de factores de riesgo cardiovascular, como la obesidad o el ...

    La proyección macular, un nuevo método para determinar la agudeza visual potencial 

    Rodríguez Mier, Fernando Avelino (Date of defense: 2014-03-14)

    The "Macular Projector" MAP, designed by us, is so effective, reliable and predictive as the Guyton-Minkowski PAMÒ and Retinometer Heine Lambda 100 in the assessment of potential visual acuity. The PAM has the advantage, ...

    La relación beneficio-riesgo del tratamiento farmacológico para la enfermedad de Alzheimer 

    Blanco Silvente, Lídia (Date of defense: 2019-07-08)

    The evidence available in the medical literature is conclusive that the risk-benefit relationship of the current medications for Alzheimer's disease is not favourable. This risk-benefit relationship is not significantly ...

    L’àcid úric, el greix perirenal i la mida renal com a nous marcadors de risc cardiovascular en població pediàtrica sana 

    Martínez-Calcerrada, José María (Date of defense: 2022-06-16)

    Despite notable advances in health promotion over the past decades, cardiovascular disease remains the leading cause of death worldwide, with obesity being a rising contributor of it. Cardiovascular risk factors appear in ...

    L’extracte de fulla d’olivera redueix la pressió arterial de pacients amb hipertensió arterial lleugera sense malaltia vascular subclínica 

    Espín Sánchez, Rufina (Date of defense: 2023-06-16)

    Introduction: Hypertension is the common cardiovascular risk factor and affects 20 to 50% of the population. Treatment, with drugs or not, involves improving lifestyle. Olive leaf extract has traditionally been taken to ...

    Mecanismos de regulación del anabolismo lipídico en el tejido adiposo del paciente obeso 

    Ortega Delgado, Francisco José (Date of defense: 2012-06-18)

    Obesity is one of the most important public health problems facing the world today. Gene expression studies applied to fat depots from obese subjects have provided important clues about the pathophysiology of adipose tissue. ...

    Methylome profiling of B and T cells along multiple sclerosis disease progression: a pilot study 

    Celarain Sanz, Naiara (Date of defense: 2023-06-26)

    Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and neurodegenerative disease characterized by the infiltration of autoreactive immune cells into the central nervous system that leads to axonal damage, ...

    Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification 

    Vallverdú Prats, Marta (Date of defense: 2023-02-03)

    Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...

    Monitoratge de la malaltia inflamatòria intestinal en la pràctica clínica mitjançant marcadors de la microbiota intestinal en mostres fecals. Estudi prospectiu 

    Miquel Cusachs, Josep Oriol (Date of defense: 2021-12-17)

    The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...

    Muerte súbita natural inexplicada: valor de la investigación genética post mortem 

    Sánchez-Molero Núñez, Olallo-Efrén (Date of defense: 2017-12-15)

    Natural death defines the death primarily attributed to an illness or an internal malfunction of the body, and not directly influenced by external forces. Most causes can be identified directly with macroscopic forensic ...

    New approaches for the study and treatment of aggressive cancers 

    Polonio Alcalá, Emma (Date of defense: 2023-05-17)

    Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...

    El nivell i la variació del risc cardiovascular en la prevenció primària de la demència 

    Fages Masmiquel, Ester (Date of defense: 2023-09-14)

    Dementia causes progressive cognitive impairment and inability to lead an independent life. Currently, there is no curative treatment for it, and thus primary prevention is essential. Age is the main risk factor for ...