Now showing items 55-74 of 96

    La proteína C reactiva y la osteocalcina descarboxilada como marcadores de arteriosclerosis preclínica en niños sanos prepuberales 

    Osiniri Kippes, Inés (Date of defense: 2015-07-15)

    La evidencia científica sugiere que la enfermedad arteriosclerótica tiene su origen en edades tempranas de la vida y su progresión está determinada por la suma de factores de riesgo cardiovascular, como la obesidad o el ...

    La proyección macular, un nuevo método para determinar la agudeza visual potencial 

    Rodríguez Mier, Fernando Avelino (Date of defense: 2014-03-14)

    The "Macular Projector" MAP, designed by us, is so effective, reliable and predictive as the Guyton-Minkowski PAMÒ and Retinometer Heine Lambda 100 in the assessment of potential visual acuity. The PAM has the advantage, ...

    La relación beneficio-riesgo del tratamiento farmacológico para la enfermedad de Alzheimer 

    Blanco Silvente, Lídia (Date of defense: 2019-07-08)

    The evidence available in the medical literature is conclusive that the risk-benefit relationship of the current medications for Alzheimer's disease is not favourable. This risk-benefit relationship is not significantly ...

    L’àcid úric, el greix perirenal i la mida renal com a nous marcadors de risc cardiovascular en població pediàtrica sana 

    Martínez-Calcerrada, José María (Date of defense: 2022-06-16)

    Despite notable advances in health promotion over the past decades, cardiovascular disease remains the leading cause of death worldwide, with obesity being a rising contributor of it. Cardiovascular risk factors appear in ...

    L’extracte de fulla d’olivera redueix la pressió arterial de pacients amb hipertensió arterial lleugera sense malaltia vascular subclínica 

    Espín Sánchez, Rufina (Date of defense: 2023-06-16)

    Introduction: Hypertension is the common cardiovascular risk factor and affects 20 to 50% of the population. Treatment, with drugs or not, involves improving lifestyle. Olive leaf extract has traditionally been taken to ...

    Mecanismos de regulación del anabolismo lipídico en el tejido adiposo del paciente obeso 

    Ortega Delgado, Francisco José (Date of defense: 2012-06-18)

    Obesity is one of the most important public health problems facing the world today. Gene expression studies applied to fat depots from obese subjects have provided important clues about the pathophysiology of adipose tissue. ...

    Methylome profiling of B and T cells along multiple sclerosis disease progression: a pilot study 

    Celarain Sanz, Naiara (Date of defense: 2023-06-26)

    Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and neurodegenerative disease characterized by the infiltration of autoreactive immune cells into the central nervous system that leads to axonal damage, ...

    Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification 

    Vallverdú Prats, Marta (Date of defense: 2023-02-03)

    Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...

    Monitoratge de la malaltia inflamatòria intestinal en la pràctica clínica mitjançant marcadors de la microbiota intestinal en mostres fecals. Estudi prospectiu 

    Miquel Cusachs, Josep Oriol (Date of defense: 2021-12-17)

    The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...

    Muerte súbita natural inexplicada: valor de la investigación genética post mortem 

    Sánchez-Molero Núñez, Olallo-Efrén (Date of defense: 2017-12-15)

    Natural death defines the death primarily attributed to an illness or an internal malfunction of the body, and not directly influenced by external forces. Most causes can be identified directly with macroscopic forensic ...

    New approaches for the study and treatment of aggressive cancers 

    Polonio Alcalá, Emma (Date of defense: 2023-05-17)

    Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...

    El nivell i la variació del risc cardiovascular en la prevenció primària de la demència 

    Fages Masmiquel, Ester (Date of defense: 2023-09-14)

    Dementia causes progressive cognitive impairment and inability to lead an independent life. Currently, there is no curative treatment for it, and thus primary prevention is essential. Age is the main risk factor for ...

    Nou mecanismes implicats en els dèficits transcripcionals i la pèrdua del BDNF en la malaltia de Huntington: descripció de noves dianes terapèutiques 

    Vidal Sancho, Laura (Date of defense: 2018-01-10)

    Huntington disease is a neurodegenerative disorder characterized by motor, cognitive and psychiatric dysfunction. Huntington disease is caused by an expanded CAG trinucleotide repeat at the exon 1 of the IT15 gen, which ...

    Nova metodologia d’anàlisi de distribucions de dosi per algorismes de càlcul de dosi absorbida en radioteràpia externa que simulen el transport de radiació en medi 

    Jurado Bruggeman, Diego (Date of defense: 2023-03-16)

    Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...

    Nuevos determinantes moleculares en la respuesta a isquemia cerebral 

    Gubern Mérida, M. Carme (Date of defense: 2015-12-18)

    Cerebral ischaemia is a potent inducer of gene expression, however, little is known about the mechanisms that regulate this expression. Studies of gene expression and the study of the mechanisms regulating this expression ...

    Osteotomia percutània distal del primer metatarsià per a la correcció de l’hàl·lux valgus. Estudi experimental comparatiu de dues tècniques quirúrgiques 

    Navarro Cano, Ester (Date of defense: 2021-06-25)

    Hallux valgus is a frequent deformity of the first ray of the foot, with progressive abduction and pronation of the first phalanx. At the same time, adduction, elevation, and pronation of the first metatarsal happens ...

    Papel del diffusion tensor imaging en la resonancia magnética cerebral como marcador predictivo del estado motor y evolución funcional en pacientes con hemorragia intracerebral 

    Terceño Izaga, Mikel (Date of defense: 2018-02-06)

    The present thesis, aims to study whether the evaluation of the CT through DTI and tractography sequences in the first 12 hours from the ICH onset, is able to predict the motor and functional outcome at 3 months. The ...

    Paper de la placofilina-2 en la miocardiopatia aritmogènica de ventricle dret: bases genètiques i mecanismes moleculars 

    Alcalde Masegu, Mireia (Date of defense: 2016-01-20)

    La mort sobtada cardíaca (MSC) es defineix com una mort natural, repentina i d’origen cardíac que succeeix durant la primera hora des de l’inici dels símptomes fins el seu desenllaç final. La MSC és la manifestació més ...

    El paper de les subunitats beta en la regulació del canal de sodi cardíac associat a la mort sobtada 

    Riuró, Helena (Date of defense: 2014-11-05)

    Les Síndromes de QT Llarg (SQTL) i de Brugada (SBr) són malalties hereditàries amb un alt risc de mort sobtada cardíaca degut a alteracions elèctriques cardíaques sense cap defecte estructural del cor. Estan relacionades ...

    Posible rol de las neuregulinas en la fisiología del tejido adiposo en asociación con obesidad y diabetes mellitus tipo 2 

    Martínez Merchan, Cristina (Date of defense: 2023-06-28)

    Different studies link the metabolic alterations of obesity with imbalances in neuregulin 4 levels. In this study we hypothesize that signaling of neuregulin isoforms (NRG) produced through ERBB receptors in human adipose ...