Now showing items 66-85 of 97

    New approaches for the study and treatment of aggressive cancers 

    Polonio Alcalá, Emma (Date of defense: 2023-05-17)

    Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...

    El nivell i la variació del risc cardiovascular en la prevenció primària de la demència 

    Fages Masmiquel, Ester (Date of defense: 2023-09-14)

    Dementia causes progressive cognitive impairment and inability to lead an independent life. Currently, there is no curative treatment for it, and thus primary prevention is essential. Age is the main risk factor for ...

    Nou mecanismes implicats en els dèficits transcripcionals i la pèrdua del BDNF en la malaltia de Huntington: descripció de noves dianes terapèutiques 

    Vidal Sancho, Laura (Date of defense: 2018-01-10)

    Huntington disease is a neurodegenerative disorder characterized by motor, cognitive and psychiatric dysfunction. Huntington disease is caused by an expanded CAG trinucleotide repeat at the exon 1 of the IT15 gen, which ...

    Nova metodologia d’anàlisi de distribucions de dosi per algorismes de càlcul de dosi absorbida en radioteràpia externa que simulen el transport de radiació en medi 

    Jurado Bruggeman, Diego (Date of defense: 2023-03-16)

    Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...

    Nuevos determinantes moleculares en la respuesta a isquemia cerebral 

    Gubern Mérida, M. Carme (Date of defense: 2015-12-18)

    Cerebral ischaemia is a potent inducer of gene expression, however, little is known about the mechanisms that regulate this expression. Studies of gene expression and the study of the mechanisms regulating this expression ...

    Osteotomia percutània distal del primer metatarsià per a la correcció de l’hàl·lux valgus. Estudi experimental comparatiu de dues tècniques quirúrgiques 

    Navarro Cano, Ester (Date of defense: 2021-06-25)

    Hallux valgus is a frequent deformity of the first ray of the foot, with progressive abduction and pronation of the first phalanx. At the same time, adduction, elevation, and pronation of the first metatarsal happens ...

    Papel del diffusion tensor imaging en la resonancia magnética cerebral como marcador predictivo del estado motor y evolución funcional en pacientes con hemorragia intracerebral 

    Terceño Izaga, Mikel (Date of defense: 2018-02-06)

    The present thesis, aims to study whether the evaluation of the CT through DTI and tractography sequences in the first 12 hours from the ICH onset, is able to predict the motor and functional outcome at 3 months. The ...

    Paper de la placofilina-2 en la miocardiopatia aritmogènica de ventricle dret: bases genètiques i mecanismes moleculars 

    Alcalde Masegu, Mireia (Date of defense: 2016-01-20)

    La mort sobtada cardíaca (MSC) es defineix com una mort natural, repentina i d’origen cardíac que succeeix durant la primera hora des de l’inici dels símptomes fins el seu desenllaç final. La MSC és la manifestació més ...

    El paper de les subunitats beta en la regulació del canal de sodi cardíac associat a la mort sobtada 

    Riuró, Helena (Date of defense: 2014-11-05)

    Les Síndromes de QT Llarg (SQTL) i de Brugada (SBr) són malalties hereditàries amb un alt risc de mort sobtada cardíaca degut a alteracions elèctriques cardíaques sense cap defecte estructural del cor. Estan relacionades ...

    Posible rol de las neuregulinas en la fisiología del tejido adiposo en asociación con obesidad y diabetes mellitus tipo 2 

    Martínez Merchan, Cristina (Date of defense: 2023-06-28)

    Different studies link the metabolic alterations of obesity with imbalances in neuregulin 4 levels. In this study we hypothesize that signaling of neuregulin isoforms (NRG) produced through ERBB receptors in human adipose ...

    Predicción del riesgo cardiovascular en población de 75 o más años del Mediterráneo 

    Guzmán Heras, Lidia Elizabeth (Date of defense: 2023-07-05)

    The increase of elderly population in Spain is one of the most important challenges for their caregivers, healthcare professionals, and the society in general. The elderly population has the highest incidence rate of ...

    Programa d'intervenció familiar multidisciplinar en atenció primària de salut basat en la teràpia de resolució de problemes per la disminució de la utilització dels recursos sanitaris del pacient crònic complex 

    Guerrero Caballero, Laura (Date of defense: 2021-12-16)

    Introduction: In the current socioeconomic context, addressing chronic diseases forces us to seek new, more efficient, strategies for complex chronic patients care. Family care can improve complex chronic patient management, ...

    Projecte EM-Line!: programa de rehabilitación cognitiva para pacientes afectados de esclerosis múltiple 

    Gich Fullà, Jordi (Date of defense: 2013-07-18)

    The clinical manifestations of Multiple Sclerosis are motor, sensitive, cerebellar and cognitive alterations. It evolves with a high degree of physical and cognitive disability. The “EM-line! Project” has its origins in ...

    Projecte “Girona Territori Cardioprotegit”: avaluació del funcionament dels desfibril·ladors públics 

    Loma-Osorio Ricón, Pablo (Date of defense: 2020-07-03)

    Introduction and aims: In recent years, public access defibrillation programs have exponentially increased the availability of automatic external defibrillators in public spaces but there are no data on their performance ...

    Regulome-seq: a novel approach for the identification of non-coding variants associated with human disease. Assessment of its applicability in 89 Brugada syndrome individuals 

    Pinsach Abuin, Mel·lina (Date of defense: 2019-01-30)

    Brugada syndrome (BrS) is a cardiac electrical disease with high susceptibility to sudden cardiac death. Approximately 25-30% of BrS patients are explained by pathogenic variants in coding sequences of cardiac ion channels, ...

    Reinterpretació de les variants genètiques identificades en una unitat especialitzada en cardiopaties familiars 

    Fernandez Falgueras, Anna (Date of defense: 2022-12-13)

    Sudden cardiac death (SCD) is defined as a natural and unexpected death due to cardiac etiology. In addition, when the cause of death remains unexplained after a complete autopsy, a cardiac arrhythmia is suspected as a ...

    Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida 

    Díaz Roldán, Ferran (Date of defense: 2023-07-03)

    Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...

    Relación entre el flujo de la arteria cerebral media y la presión en la arteria carótida interna durante la endarterectomía carotídea 

    Rodríguez Cabeza, Patricia (Date of defense: 2017-10-03)

    Risk of cerebral hypoperfusion during carotid endarterectomy arterial is the main limiting factor of this technique. Shunt allows partial maintenance of cerebral perfusion during clamping. We analyze the hemodynamic ...

    Relevance of the epigenetic regulation exercised by hepatic microRNAs in the fatty liver arena: from the bedside to the bench 

    Latorre Luque, Jèssica (Date of defense: 2020-03-04)

    Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver ...

    Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions 

    Muñoz San Martín, María (Date of defense: 2021-09-15)

    Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...