Now showing items 72-91 of 97

    Papel del diffusion tensor imaging en la resonancia magnética cerebral como marcador predictivo del estado motor y evolución funcional en pacientes con hemorragia intracerebral 

    Terceño Izaga, Mikel (Date of defense: 2018-02-06)

    The present thesis, aims to study whether the evaluation of the CT through DTI and tractography sequences in the first 12 hours from the ICH onset, is able to predict the motor and functional outcome at 3 months. The ...

    Paper de la placofilina-2 en la miocardiopatia aritmogènica de ventricle dret: bases genètiques i mecanismes moleculars 

    Alcalde Masegu, Mireia (Date of defense: 2016-01-20)

    La mort sobtada cardíaca (MSC) es defineix com una mort natural, repentina i d’origen cardíac que succeeix durant la primera hora des de l’inici dels símptomes fins el seu desenllaç final. La MSC és la manifestació més ...

    El paper de les subunitats beta en la regulació del canal de sodi cardíac associat a la mort sobtada 

    Riuró, Helena (Date of defense: 2014-11-05)

    Les Síndromes de QT Llarg (SQTL) i de Brugada (SBr) són malalties hereditàries amb un alt risc de mort sobtada cardíaca degut a alteracions elèctriques cardíaques sense cap defecte estructural del cor. Estan relacionades ...

    Posible rol de las neuregulinas en la fisiología del tejido adiposo en asociación con obesidad y diabetes mellitus tipo 2 

    Martínez Merchan, Cristina (Date of defense: 2023-06-28)

    Different studies link the metabolic alterations of obesity with imbalances in neuregulin 4 levels. In this study we hypothesize that signaling of neuregulin isoforms (NRG) produced through ERBB receptors in human adipose ...

    Predicción del riesgo cardiovascular en población de 75 o más años del Mediterráneo 

    Guzmán Heras, Lidia Elizabeth (Date of defense: 2023-07-05)

    The increase of elderly population in Spain is one of the most important challenges for their caregivers, healthcare professionals, and the society in general. The elderly population has the highest incidence rate of ...

    Programa d'intervenció familiar multidisciplinar en atenció primària de salut basat en la teràpia de resolució de problemes per la disminució de la utilització dels recursos sanitaris del pacient crònic complex 

    Guerrero Caballero, Laura (Date of defense: 2021-12-16)

    Introduction: In the current socioeconomic context, addressing chronic diseases forces us to seek new, more efficient, strategies for complex chronic patients care. Family care can improve complex chronic patient management, ...

    Projecte EM-Line!: programa de rehabilitación cognitiva para pacientes afectados de esclerosis múltiple 

    Gich Fullà, Jordi (Date of defense: 2013-07-18)

    The clinical manifestations of Multiple Sclerosis are motor, sensitive, cerebellar and cognitive alterations. It evolves with a high degree of physical and cognitive disability. The “EM-line! Project” has its origins in ...

    Projecte “Girona Territori Cardioprotegit”: avaluació del funcionament dels desfibril·ladors públics 

    Loma-Osorio Ricón, Pablo (Date of defense: 2020-07-03)

    Introduction and aims: In recent years, public access defibrillation programs have exponentially increased the availability of automatic external defibrillators in public spaces but there are no data on their performance ...

    Regulome-seq: a novel approach for the identification of non-coding variants associated with human disease. Assessment of its applicability in 89 Brugada syndrome individuals 

    Pinsach Abuin, Mel·lina (Date of defense: 2019-01-30)

    Brugada syndrome (BrS) is a cardiac electrical disease with high susceptibility to sudden cardiac death. Approximately 25-30% of BrS patients are explained by pathogenic variants in coding sequences of cardiac ion channels, ...

    Reinterpretació de les variants genètiques identificades en una unitat especialitzada en cardiopaties familiars 

    Fernandez Falgueras, Anna (Date of defense: 2022-12-13)

    Sudden cardiac death (SCD) is defined as a natural and unexpected death due to cardiac etiology. In addition, when the cause of death remains unexplained after a complete autopsy, a cardiac arrhythmia is suspected as a ...

    Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida 

    Díaz Roldán, Ferran (Date of defense: 2023-07-03)

    Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...

    Relación entre el flujo de la arteria cerebral media y la presión en la arteria carótida interna durante la endarterectomía carotídea 

    Rodríguez Cabeza, Patricia (Date of defense: 2017-10-03)

    Risk of cerebral hypoperfusion during carotid endarterectomy arterial is the main limiting factor of this technique. Shunt allows partial maintenance of cerebral perfusion during clamping. We analyze the hemodynamic ...

    Relevance of the epigenetic regulation exercised by hepatic microRNAs in the fatty liver arena: from the bedside to the bench 

    Latorre Luque, Jèssica (Date of defense: 2020-03-04)

    Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver ...

    Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions 

    Muñoz San Martín, María (Date of defense: 2021-09-15)

    Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...

    Sistema immunitari i marcadors de risc cardiometabòlic en l'edat pediàtrica 

    Gispert-Saüch Puigdevall, Montse (Date of defense: 2018-03-02)

    We studied the relationship between the circulating levels of the innate immune system molecules (α-defensins and BPI) and the acquired immune system (IgG, IgA and IgM) with obesity and cardiometabolic risk factors in ...

    Statistical methods to manage and analyse real world data. Development of a health observatory in Alt Empordà 

    Franquet Bonet, Álvaro (Date of defense: 2021-12-01)

    The objective of this thesis is to explore in greater depth the process of creating a public health observatory and the processing of the information needed to take territorial decisions in the county of Alt Empordà. The ...

    Study of two analogues of pituitary adenylate cyclase-activating polypeptide as novel therapeutic compounds for Huntington’s disease 

    Solés Tarrés, Irene (Date of defense: 2023-06-14)

    Huntington’s disease (HD) is a neurodegenerative genetic disorder with no effective treatment characterized by motor discoordination, deficits in cognitive function (acquiring new knowledges, memory, understanding…), and ...

    The relevance of hydrogen sulfide (H2S) in obesity and adipose tissue physiology 

    Comas Vila, Ferran (Date of defense: 2021-05-14)

    Hydrogen sulfide (H2S), regarded as the third gasotransmitter, plays diverse physiological and pathological roles in the body along with another two gasotransmitters, including nitric oxide (NO) and carbon monoxide (CO). ...

    Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models 

    Cabezas Llobet, Núria (Date of defense: 2019-02-28)

    Huntington's disease (MH) is a progressive neurodegenerative disorder characterized by a motor dysfunction, cognitive impairment, and psychiatric symptoms. At neuropathological level, it has been described that cognitive ...

    Trafficking and function of the voltage-gated sodium channel β2 subunit 

    Cortada Almar, Èric (Date of defense: 2020-11-24)

    The sodium channel β2 subunit is a component of the voltage-gated sodium channel (NaV), a large multimeric protein complex. In the heart, NaV is mainly composed of a pore-forming α subunit, NaV1.5, and two associated ...