Universitat de Barcelona
Now showing items 21-40 of 229
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded in the structure, ...
[eng] The Central nervous system (CNS) originates from the coordinated events that result into neural specification and the morphogenic events that shape the neural tube (NT). Then, the embryonic NT should grow and generate ...
Las personas con insuficiencia renal crónica (ERC) suelen manifestar sentirse más fatigados al terminar la sesión de diálisis (HD). Cabe destacar que se trata de una población compuesta por pacientes que pueden presentar ...
INTRODUCCIÓ: Actualment el bypass gàstric en Y-de-Roux és la tècnica més freqüent portada a terme en l’àmbit internacional en què, en ser de tipus mixta, es produeix una combinació dels elements restrictius i de malabsorció. ...
En células aisladas de corazón de rata se caracterizaron las actividades triacilglicerol ester hidrolasas. Se detecta la presencia de actividad acida localizada en el interior de los lisosomas, que no es sensible ni a la ...
L’insomni és un trastorn caracteritzat per la insatisfacció en la qualitat i/o quantitat del son, que persisteix durant un considerable període de temps. És un son no reparador, amb conseqüències diürnes com la fatiga, la ...
DYRK1A es un gen del cromosoma 21 humano que codifica para una proteína quinasa constitutivamente activa que fosforila a sustratos que son clave en el desarrollo del cerebro. La proteína DYRK1A regula el crecimiento del ...
El cáncer de pulmón de célula pequeña (CPCP) es el subtipo mas agresivo del cáncer de pulmón. Mas de la mitad de los pacientes se diagnostican con enfermedad diseminada, donde el tratamiento de elección desde la década de ...
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual se mantiene la ...
La presente tesis doctoral consta de 4 proyectos independientes centrados en el estudio de las causas genéticas del cáncer colorrectal (CCR) hereditario: A) Estudio de una variante común (rs2075786) en el gen de la ...
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...
[eng] Cellular senescence is a response to stress and damage, ant it is known to activate innate immune cells. However, the mechanisms by which senescent cells interact with the adaptive arm of the immune system and their ...
Macrophyte systems are globally vulnerable to overgrazing, often shifting precipitously to functionally poorer alternative stable states triggered by herbivore population outbreaks. Sea urchin herbivory can cause shifts ...
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major sub processes: the ...
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene bodies.Taking into ...
[eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human diseases are of ...
Un dels factors pronòstics més importants en la leucèmia limfàtica crònica (LLC) són les categories de risc citogenètic, basades en la detecció de del(13q), trisomia 12, del(11q) i del(17p) per hibridació in situ fluorescent ...
[eng] Fungal infections pose a serious health threat, affecting >1,000 million people and causing ~1.5 million deaths each year. The problem is growing due to insufficient diagnostic and therapeutic options, increased ...
Xenopus laevis oocytes are transcriptionally silent cells that require hormone stimulation for maturing into fecundation-competent eggs. Meiosis resumption underlying oocyte maturation is governed by sequential waves of ...
Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively investigated, its ...
