Now showing items 167-186 of 229

    Papel de las regiones reguladoras de la expresión génica en la adaptación a factores ambientales en procariotas 

    Fernández Vidal, Leyden (Date of defense: 2015-01-22)

    Se ha demostrado en un número de estudios de metagenómica que la adición y la pérdida de genes específicos ha permitido a los microbiomas adaptarse a condiciones ambientales típicas de los entornos. Pero, aún no se conoce ...

    Papel del colágeno VI en la homeostasis del músculo esquelético y tejido adiposo: implicaciones en la patofisiología de las distrofias musculares 

    Rodríguez García, Mª Ángeles (Date of defense: 2016-10-17)

    El colágeno VI es una proteína de la matriz extracelular cuyos defectos conducen a una variedad de trastornos musculares en humanos caracterizados por una debilidad muscular entre otros múltiples síntomas. Tanto el colágeno ...

    Papel del Polietilenglicol 35 en la Modulación de los Procesos Inflamatorios Asociados al Páncreas 

    Ferrero Andrés, Ana (Date of defense: 2020-12-22)

    A pesar de las extensas investigaciones durante las últimas décadas, la pancreatitis aguda (PA) continúa siendo un reto para el manejo clínico, con una importante carga de morbilidad, mortalidad y coste, cuando la enfermedad ...

    Paper de la proteïna scavenger AIM en l’activació de macròfags i desenvolupament de cèl·lules escumoses 

    Amézaga Solé, Núria (Date of defense: 2013-09-05)

    La proteïna secretada Apoptosis inhibitor expressed by macrophages (AIM) és expressada per macròfags tissulars en condicions d’inflamació. És una glicoproteïna que pertany a la família dels Receptors Scavenger Rics en ...

    Paper del miRNA en la diferenciació de les cèl.lules mare 

    Ventayol Espinazo, Marina (Date of defense: 2013-02-22)

    Les patologies renals s’han convertit en una problemàtica a nivell mundial, en l’actualitat poden afectar a una de cada 9 persones al llarg de la seva vida i porten associats elevats costos econòmics. Malgrat els últims ...

    Parmbsc1: Parameterization and Validation of a new State-of-the-art Force Field for DNA Simulations 

    Ivani, Iván (Date of defense: 2016-12-13)

    Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological macromolecules. Originated ...

    Patterns of activity in marine planktonic copepods: diel rhythms and driving factors 

    Olivares Requena, Manuel (Date of defense: 2021-02-19)

    Marine planktonic copepods play a key ecological role in pelagic food webs. The study of their patterns of activity is fundamental in order to better understand the processes involved in the transfer of energy from lower ...

    Patterns of genetic and morphologic diversity in Antarctic sponges = Modelos de diversidad genética y morfológicas en las esponjas antárcticas 

    Carella, Mirco (Date of defense: 2018-07-13)

    The Antarctic bottoms harbour rich communities of sponges, which play an important role in structuring benthic habitats. Many Antarctic sponge species have been discovered in the past but most of them were poorly described ...

    Pharmaceutical development of nanosystems for the delivery of drugs in epidermis and hair follicles, skin biodistribution studies 

    Pena Rodríguez, Eloy (Date of defense: 2022-07-18)

    [eng] Different transdermal drug delivery platforms have been developed for epidermal and follicular targeting. Nanoformulations have been developed, optimised and physicochemically characterised with complementary techniques. ...

    PIF3 (phytochrome•interaeting factor 3) and Circadian Clock interaction in the regulation of plant growth 

    Soy Platero, Judit (Date of defense: 2014-07-17)

    Arabidopsis thaliana seedling growth and development is influenced by both external (such as light and temperature) and internal (like hormones or circadian clock) factors. In short-day (SD) growing conditions, it is known ...

    Plant diversity and vegetation of the Andean Páramo 

    Peyre, Gwendolyn (Date of defense: 2015-05-12)

    The páramo is a high mountain ecosystem that includes the natural and semi-natural habitats located between the montane treeline and the permanent snowline in the humid Northern Andes. Given its recent origin and continental ...

    Post-transcriptional control of anti-tumor immune responses 

    Fernández Alfara, Marcos (Date of defense: 2022-04-07)

    Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling proliferation, survival, ...

    Programas de splicing y desarrollo neuronal: función de la quinasa KIS 

    Moreno Aguilera, Marcos (Date of defense: 2023-09-29)

    [spa] El splicing alternativo es un proceso que además de proporcionar diversidad al transcriptoma y proteoma celular, añade una nueva capa de regulación en la expresión de proteínas y en la función que estas desempeñan. ...

    Protective role of polyethylene glycol 35 against hepatic cold and warm ischemia 

    Silva, Rui Gonçalo Teixeira da (Date of defense: 2022-09-16)

    Steatotic livers are considerably more prone to IRI, in which turn, it is known to impair mitochondrial function. Our working hypothesis lies on the fact that impaired mitochondrial function and reduced protection against ...

    Proteomic profile in postmortem brain in chronic schizopfrenia 

    Vera Montecinos, América (Date of defense: 2021-03-23)

    Schizophrenia is a complex psychiatric disorder involving dysregulation of multiple pathways. In the last decades, the cortico-cerebellar-thalamo-cortical circuit has been proposed to play a key role in cognitive impairments ...

    Refining prognosis capacity and implementing priciples of personalized therapies for Neurofibromatosis Type 2 

    Catasús Segura, Núria (Date of defense: 2022-05-31)

    Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular schwannomas (VS), ...

    Regulation of ribonucleotide reduction in facultative anaerobic pathogens and its influence in bacterial fitness, virulence and biofilm formation 

    Pedraz López, Lucas (Date of defense: 2020-01-13)

    The perpetuation of life depends on the ability to reproduce. All known forms of life use DNA as genetic information storage. Ribonucleotide reduction is the process by which ribonucleotides (NTPs) are transformed into ...

    Responses to environmental xenobiotics: from endocrine disruption to lipid homeostasis imbalance 

    Dimastrogiovanni, Giorgio (Date of defense: 2015-09-18)

    Many chemicals are continuously entering into the aquatic environment, as a result of their widespread use, disposal and accidental release. Several of these xenobiotics may disrupt reproductive functions of both vertebrates ...

    Resultados funcionales de la participación de las proteínas insulator en la organización de la cromatina 

    Rodríguez Sánchez, Maria de los Ángeles (Date of defense: 2019-11-22)

    Las proteínas insulator son componentes esenciales de la organización tridimensional de la cromatina ya que son capaces de establecer interacciones entre regiones distantes de la mediante su capacidad de asociarse a otras ...

    The role of behavioural and feedback mechanisms in mediating herbivory processes in Mediterranean seagrass ecosystems 

    Buñuel Moreno, Xavier (Date of defense: 2021-07-13)

    The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...