Now showing items 182-201 of 229

    Refining prognosis capacity and implementing priciples of personalized therapies for Neurofibromatosis Type 2 

    Catasús Segura, Núria (Date of defense: 2022-05-31)

    Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular schwannomas (VS), ...

    Regulation of ribonucleotide reduction in facultative anaerobic pathogens and its influence in bacterial fitness, virulence and biofilm formation 

    Pedraz López, Lucas (Date of defense: 2020-01-13)

    The perpetuation of life depends on the ability to reproduce. All known forms of life use DNA as genetic information storage. Ribonucleotide reduction is the process by which ribonucleotides (NTPs) are transformed into ...

    Responses to environmental xenobiotics: from endocrine disruption to lipid homeostasis imbalance 

    Dimastrogiovanni, Giorgio (Date of defense: 2015-09-18)

    Many chemicals are continuously entering into the aquatic environment, as a result of their widespread use, disposal and accidental release. Several of these xenobiotics may disrupt reproductive functions of both vertebrates ...

    Resultados funcionales de la participación de las proteínas insulator en la organización de la cromatina 

    Rodríguez Sánchez, Maria de los Ángeles (Date of defense: 2019-11-22)

    Las proteínas insulator son componentes esenciales de la organización tridimensional de la cromatina ya que son capaces de establecer interacciones entre regiones distantes de la mediante su capacidad de asociarse a otras ...

    The role of behavioural and feedback mechanisms in mediating herbivory processes in Mediterranean seagrass ecosystems 

    Buñuel Moreno, Xavier (Date of defense: 2021-07-13)

    The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...

    Role of Capicua-L in RTK signaling and endocycle regulation 

    Rodríguez Muñoz, Laura (Date of defense: 2021-05-13)

    The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...

    Role of D-fagomine and omega-3 plyunsaturated fatty acids on gut microbia and related metabolic changes in healthy rats and in a model of fat-induced prediabetes 

    Hereu Planellas, Mercè (Date of defense: 2019-07-19)

    Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...

    Role of DPPA3 in hypoxia and tumour dormancy in cancer 

    Cuesta Borràs, Estefania (Date of defense: 2019-11-28)

    Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...

    Role of kinase DYRK1A in the neurogenesis of the embryonic telencephalon 

    Trujillano Fernández, Alejandro (Date of defense: 2024-02-08)

    [eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...

    Role of MAF in bone metastasis 

    Bellmunt i Tarragó, Anna (Date of defense: 2017-12-15)

    The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. ...

    Role of Mfn2 in Macrophage Inflammatory Responses 

    Tur Torres, Juan (Date of defense: 2017-03-22)

    Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several ...

    Role of p38alpha kinase in myeloid cells during lung metastasis and inflammation 

    Borràs Eroles, Clara (Date of defense: 2023-02-09)

    [eng] The lungs are constantly exposed to external particles and microbes, so their particular immune environment is immunosuppressive to avoid unnecessary inflammatory responses. This increases the susceptibility of this ...

    Role of p38α in lung tumor progression 

    Vitos Faleato, Jessica (Date of defense: 2018-01-19)

    Tumors evolve by sequentially acquiring genetic abnormalities, like K-Ras activation and Tp53 loss of function, which enable transformed cells to survive, proliferate, invade, and reprogram their microenvironment. ...

    The role of the histone variant macroH2A in the regulation of chromatin architecture 

    Corujo Garcia, David (Date of defense: 2019-12-10)

    In the eukaryotic cell nucleus, DNA is tightly wrapped around histone complexes, forming a dynamic structure known as chromatin. The nucleosome particle is the basic repeating unit of the chromatin fiber and its protein ...

    ROV-based ecological study and management proposals for the offshore marine protected area of Cap de Creus (NW Mediterranean) 

    Domínguez Carrió, Carlos (Date of defense: 2018-07-12)

    Aiming to improve the conservation status of the European seas, the Marine Strategy Framework Directive (MSFD) was adopted in 2008, establishing a general framework for all EU countries in the field of marine environmental ...

    Secretory markers of dense-core vesicles in Alzheimer's disease 

    Barranco Muñoz, Neus (Date of defense: 2020-06-22)

    The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...

    Setting up stem cell therapy for human retina: from organotypic cultures to cell fusion understanding 

    Bonilla-Pons, Sergi A. (Date of defense: 2021-04-30)

    Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative ...

    Sistema de paneles virtuales de genes para genómica clínica basado en NGS 

    Sellarès Rubio, Arnau (Date of defense: 2022-11-16)

    [spa] El diagnóstico de enfermedades humanas originadas a causa de variantes y mutaciones en el ADN de cada persona está experimentando un cambio de paradigma, desde la aproximación genética tradicional hacia una que ...

    SLIMP: a mitochondrial protein involved in cell cycle regulation 

    Pons Pons, Alba (Date of defense: 2021-12-16)

    SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog of the Drosophila ...

    Smad binding codes broken by WW domain containing proteins = Desxifrant els codis d’unió a Smad de les proteïnes amb dominis WW 

    Aragón Altarriba, Eric (Date of defense: 2013-12-13)

    Cell fate is controlled by a multitude of signals and loss of this control has devastating consequences for living organisms. One of the key players in this network of signals is the TGF-beta family of cytokines. These ...