Browsing Facultat de Biologia by Title

Secretory markers of dense-core vesicles in Alzheimer's disease

Barranco Muñoz, Neus (Date of defense: 2020-06-22)

The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...

Setting up stem cell therapy for human retina: from organotypic cultures to cell fusion understanding

Bonilla-Pons, Sergi A. (Date of defense: 2021-04-30)

Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative ...

Sistema de paneles virtuales de genes para genómica clínica basado en NGS

Sellarès Rubio, Arnau (Date of defense: 2022-11-16)

[spa] El diagnóstico de enfermedades humanas originadas a causa de variantes y mutaciones en el ADN de cada persona está experimentando un cambio de paradigma, desde la aproximación genética tradicional hacia una que ...

SLIMP: a mitochondrial protein involved in cell cycle regulation

Pons Pons, Alba (Date of defense: 2021-12-16)

SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog of the Drosophila ...

Smad binding codes broken by WW domain containing proteins = Desxifrant els codis d’unió a Smad de les proteïnes amb dominis WW

Aragón Altarriba, Eric (Date of defense: 2013-12-13)

Cell fate is controlled by a multitude of signals and loss of this control has devastating consequences for living organisms. One of the key players in this network of signals is the TGF-beta family of cytokines. These ...

SP Transcription factors in psychotic disorders

Pinacho Garcia, Raquel (Date of defense: 2015-07-17)

Psychotic disorders including bipolar disorder and schizophrenia are a leading cause of disability across the world but the underlying pathophysiological mechanisms remain poorly understood. Available treatments are ...

Study and characterization of the Drosophila wg(1)-enhancer in development, regeneration and tumorigenesis

Gracia Latorre, Elena (Date of defense: 2023-06-01)

[eng] Enhancers are the master regulators of gene expression. Genes rely on them to be differentially expressed in different tissues, developmental time points or contexts. In recent years, it has been reported that although ...

Study of complex chromosomal rearrangements in cancer. The role of extrachromosomal circular DNA as a genome remodeler in neuroblastoma

Rodriguez Fos, Elias (Date of defense: 2020-07-15)

This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological ...

Study of molecular mechanisms implicated in the TGF-beta oncogenic effect in Glioma

Gonzàlez Juncà, Alba (Date of defense: 2013-11-15)

The TGF-beta oncogenic effect has been widely studied. In glioma, TGF-beta has an oncogenic role increasing cell proliferation and glioma-initiating cell (GIC) self-renewal capacity. During the investigation of this thesis, ...

Study of the role of substrate stiffness and force transmission to the nucleus in nucleocytoplasmic transport, nuclear pore conformation, genome organization and gene expression

Molina Jordán, Marc (Date of defense: 2023-12-04)

[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. However, how ...

Study of the Secundary Neurulation in the chick embryo, a model to understand neural tube defects = Estudio de la neurulación secundaria en el embrión del pollo, un modelo para entender los defectos del tubo neural

González Gobartt, Elena (Date of defense: 2019-11-29)

Body axis elongation is a hallmark of the vertebrate embryo, which also comprises the morphogenesis of the caudal neural tube (NT). The contribution of bipotential neuromesodermal progenitors (NMPs) to the cranio-caudal ...

A systematic and comprehensive approach for large-scale genome-wide association studies. Unraveling non-additive inheritance models in age-related diseases

Guindo Martínez, Marta (Date of defense: 2019-12-18)

Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...

Systematic characterization of the genome-wide and nuclear distribution of six linker histone H1 variants in human cancer cells

Salinas Pena, Mónica (Date of defense: 2023-09-20)

[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...

Systematics, biogeography and evolution of selected widespread reptile genera from the arid areas of North Africa and Arabia

Metallinou, Margarita (Date of defense: 2014-07-17)

The arid areas of North Africa and Arabia cover a surface of more than 13 million square kilometers and are characterized by their extreme temperatures, diversity of desert habitats and well-adapted flora and fauna. The ...

Taxonomy, distribution and community composition of megabenthic non-crustacean invertebrates in the deep Catalan margin = Taxonomía, distribución y composición de la comunidad de invertebrados no crustáceos del megabentos del Mar Catalán profundo

Mecho Lausac, Ariadna (Date of defense: 2014-10-15)

The study of the non-crustacean invertebrates dwelling on the deep Mediterranean Sea is of interest for different marine science disciplines, being the diversity of species and their distributions largely unexplored. In ...