Now showing items 228-229 of 229

    Variability in domain-scale regional mutation density across tissues and individuals 

    Salvadores Ferreiro, Marina (Date of defense: 2024-01-18)

    [eng] Mutations exhibit an uneven distribution across the human genome, with a regional mutation density (RMD) influenced by chromatin landscapes and replication timing. While there is a good understanding of this variation, ...

    β-cells cis-regulatory networks and type 1 diabetes 

    Ramos Rodríguez, Mireia (Date of defense: 2020-11-06)

    Type 1 Diabetes (T1D) is a ­cell­targeted autoimmune disease, leading to a reduction in pancreatic ­cell mass that renders patients insulin­dependent for life. In early stages of the disease, cells from the immune system ...