Now showing items 12-31 of 46

    From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors 

    Codony Gisbert, Sandra (Date of defense: 2020-09-17)

    Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide ...

    GDF15, a novel regulator of the AMPK-mediated antidiabetic actions of PPARβ/δ and metformin 

    Aguilar Recarte, David (Date of defense: 2021-09-20)

    Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces the development of ...

    Generació de "building blocks" enantiopurs amb un estereocentre quaternari. Aplicació a la síntesi de productes naturals i compostos biològicament actius 

    Ordeix i Utiel, Sergi (Date of defense: 2022-11-11)

    [cat] Els alcaloides indòlics monoterpènics del grup leuconolam-leuconoxina-mersicarpina [(–)- mersicarpina, (–)-leuconoxina, (+)-melodinina E] i la (–)-kopsiyunnanina K presenten una interessant activitat biològica juntament ...

    Isocyanide as a key functional group for the synthesis of biologically active compounds 

    Abás Prades, Sònia (Date of defense: 2018-05-31)

    The distinctive reactivity of isocyanides has been recognised as an advantageous characteristic for the formation of heterocyclic compounds. In the present manuscript new synthetic possibilities are explored involving the ...

    Mecanismos implicados en la neurodegeneración inducida por dieta grasa en modelos de senescencia 

    Palomera Ávalos, Verónica (Date of defense: 2018-01-26)

    La población mundial está envejeciendo, la mayoría de países del mundo están experimentando un aumento en el número y la proporción de personas mayores. Los últimos datos publicados de la ONU en 2017 informan que se espera ...

    Modificaciones en la herencia epigenética inducidas por la dieta grasa revertidas por el resveratrol en el modelo murino SAMP8 

    Izquierdo Cadenas, Vanesa (Date of defense: 2021-07-21)

    Factores ambientales como el ejercicio, el estrés o la dieta contribuyen a la patogénesis de enfermedades asociadas al deterioro cognitivo y al envejecimiento, modulando mecanismos de expresión génica que son susceptibles ...

    Multi-functionalization of micro- and nanoparticles for cancer theranostics 

    Amirthalingam, Ezhil (Date of defense: 2018-10-01)

    This thesis has its main focus on developing multi-functional nanomaterials, that we called nano- and microtools through two different approaches, top-down to provide support and bottom up to give functionality to prepare ...

    Multitarget strategies in search of novel drug candidates against Alzheimer’s disease 

    Pont Masanet, Caterina (Date of defense: 2020-01-31)

    Alzheimer’s disease (AD) is the most common form of dementia and one of the most important health-care problems in the world, due to its high prevalence and unaffordable personal and economic impact. Moreover, current ...

    Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones 

    Duart Castells, Leticia (Date of defense: 2020-02-25)

    Drugs of abuse represent a global problem not only at a health level, but also at a social and economic extent. Recently, a tidal wave of new emerging psychoactive substances has completely modified the illicit drug market, ...

    New Palladium-Catalysed Intramolecular Coupling Reactions: Nucleophilic Addition toAldehydes and C-H Carbene Insertion 

    Mariani, Francesco (Date of defense: 2016-07-05)

    Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C—C bond forming reactions, recent research has demonstrated that the same palladium intermediates can also react with ...

    New polycyclic small molecules as ion channel modulators 

    Barniol Xicota, Marta (Date of defense: 2017-01-13)

    L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la grip, el receptor ...

    Nous antagonistes del receptor NMDA pel tractament de la malaltia d’Alzheimer. Caracterització farmacològica in vivo 

    Companys Alemany, Júlia (Date of defense: 2022-07-15)

    Actualment, el tractament de la malaltia d’Alzheimer (MA) és una necessitat mèdica no coberta, ja que només existeixen tres grups de fàrmacs aprovats que no són suficientment eficaços pel control de la malaltia. La naturalesa ...

    Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates 

    Sola Lao, Irene (Date of defense: 2016-11-15)

    This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...

    Novel multi-target directed ligands as drug candidates against Alzheimer’s disease 

    Pérez Areales, Francisco Javier (Date of defense: 2017-07-14)

    Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...

    Novel potential determinants in endoplasmic reticulum stress, inflammation and insulin resistance: Apo CIII and sAPPβ 

    Botteri, Gaia (Date of defense: 2018-03-14)

    Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...

    Novel ᴫ-Functional Components of Micro- and Nanoparticles for Nanomedicine 

    Alea Reyes, María Elisa (Date of defense: 2017-07-17)

    The present thesis is included in the area of Nanomedicine and supramolecular chemistry, focused on the design and preparation of different nano and microtools for delivery, therapy and sensing. Initially, the synthesis ...

    Nuevas aproximaciones a compuestos policíclicos complejos y transformaciones de los mismos 

    Otermin Esteras, Ane (Date of defense: 2016-11-23)

    En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...

    Open-chain building blocks from chiral lactams. Enantioselective synthesis of macrocyclic nitrogen-containing natural products 

    Guignard, Guillaume Michel Pablo (Date of defense: 2016-06-23)

    1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive cleavage of the ...

    Palladium in azaheterocyclic synthesis: α-arylation of sulfones, domino processes and C-H carbene insertion reactions 

    Pérez Janer, Ferran (Date of defense: 2018-06-01)

    Among transition metals used in organic chemistry, palladium has greatly contributed to the development of modern organic synthesis. This thesis is focused on the development of novel and efficient methodologies for the ...

    Palladium, ruthenium and iron in intramolecular transition metal-catalyzed carbene functionalization reactions of amino-tethered α-diazoesters 

    Amenta, Arianna (Date of defense: 2020-03-27)

    Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...