Now showing items 20-39 of 46

    Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones 

    Duart Castells, Leticia (Date of defense: 2020-02-25)

    Drugs of abuse represent a global problem not only at a health level, but also at a social and economic extent. Recently, a tidal wave of new emerging psychoactive substances has completely modified the illicit drug market, ...

    New Palladium-Catalysed Intramolecular Coupling Reactions: Nucleophilic Addition toAldehydes and C-H Carbene Insertion 

    Mariani, Francesco (Date of defense: 2016-07-05)

    Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C—C bond forming reactions, recent research has demonstrated that the same palladium intermediates can also react with ...

    New polycyclic small molecules as ion channel modulators 

    Barniol Xicota, Marta (Date of defense: 2017-01-13)

    L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la grip, el receptor ...

    Nous antagonistes del receptor NMDA pel tractament de la malaltia d’Alzheimer. Caracterització farmacològica in vivo 

    Companys Alemany, Júlia (Date of defense: 2022-07-15)

    Actualment, el tractament de la malaltia d’Alzheimer (MA) és una necessitat mèdica no coberta, ja que només existeixen tres grups de fàrmacs aprovats que no són suficientment eficaços pel control de la malaltia. La naturalesa ...

    Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates 

    Sola Lao, Irene (Date of defense: 2016-11-15)

    This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...

    Novel multi-target directed ligands as drug candidates against Alzheimer’s disease 

    Pérez Areales, Francisco Javier (Date of defense: 2017-07-14)

    Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...

    Novel potential determinants in endoplasmic reticulum stress, inflammation and insulin resistance: Apo CIII and sAPPβ 

    Botteri, Gaia (Date of defense: 2018-03-14)

    Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...

    Novel ᴫ-Functional Components of Micro- and Nanoparticles for Nanomedicine 

    Alea Reyes, María Elisa (Date of defense: 2017-07-17)

    The present thesis is included in the area of Nanomedicine and supramolecular chemistry, focused on the design and preparation of different nano and microtools for delivery, therapy and sensing. Initially, the synthesis ...

    Nuevas aproximaciones a compuestos policíclicos complejos y transformaciones de los mismos 

    Otermin Esteras, Ane (Date of defense: 2016-11-23)

    En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...

    Open-chain building blocks from chiral lactams. Enantioselective synthesis of macrocyclic nitrogen-containing natural products 

    Guignard, Guillaume Michel Pablo (Date of defense: 2016-06-23)

    1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive cleavage of the ...

    Palladium in azaheterocyclic synthesis: α-arylation of sulfones, domino processes and C-H carbene insertion reactions 

    Pérez Janer, Ferran (Date of defense: 2018-06-01)

    Among transition metals used in organic chemistry, palladium has greatly contributed to the development of modern organic synthesis. This thesis is focused on the development of novel and efficient methodologies for the ...

    Palladium, ruthenium and iron in intramolecular transition metal-catalyzed carbene functionalization reactions of amino-tethered α-diazoesters 

    Amenta, Arianna (Date of defense: 2020-03-27)

    Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...

    Participación de la modulación epigenética en modelos murinos de envejecimiento y enfermedad de Alzheimer 

    Griñán Ferré, Christian (Date of defense: 2016-12-12)

    Existe una correlación positiva entre el incremento de la esperanza de vida y el aumento de las enfermedades crónicas. Se ha establecido que el envejecimiento es el principal factor de riesgo en la aparición de trastornos ...

    Phenotyping of sigma-1 receptor knock-out rodents 

    Codony Soler, Xavier (Date of defense: 2022-06-02)

    The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species and its structure ...

    Preparació i Avaluació Biològica de Nous Sistemes Heterocíclics Nitrogenats 

    Viñas Simón, Miquel (Date of defense: 2023-04-14)

    [cat] Aquest treball està orientat en l’estudi de nous sistemes heterocíclics nitrogenats amb potencial activitat biològica, concretament, en la recerca de nous antitumorals per inhibició enzimàtica. S’ha descrit la ...

    Safety and efficacy investigations for new prenatal neuroprotective therapies. Applications in a model of intrauterine growth restriction (IUGR). 

    Kühne, Britta Anna (Date of defense: 2022-10-21)

    [eng] Intrauterine growth restriction (IUGR) is defined as a significant reduction on fetal growth rate, resulting in a birth weight below the 10th percentile for the corresponding gestational age (Sharma et al., 2016). ...

    Síntesis de alcaloides decahidroquinolínicos de los grupos de la gefirotoxina, flegmarina y cilindricina 

    Piccichè, Miriam (Date of defense: 2021-12-10)

    Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...

    Síntesis de compuestos bioactivos: Ligandos de los receptores imidazolínicos I(2) e inhibidores de la enzima PEPCK 

    Rodríguez Arévalo, Sergio (Date of defense: 2021-11-26)

    La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...

    Síntesis formal enantioselectiva del macrólido calispongiolida 

    Urbina Teixidor, Aina (Date of defense: 2020-06-19)

    La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...

    Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition 

    Puigoriol Illamola, Dolors (Date of defense: 2020-09-10)

    The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...