Browsing Departament de Biomedicina by Title

Now showing items 26-31 of 31

Regulació i funció en resposta a diferents tipus d’estrès de la CaMKK Ckk2

Martin Ramos, Edgar (Date of defense: 2021-04-26)

Les proteïnes de la família de les CaM quinases (CAMK en anglès), l’activitat de les quals és dependent del complex calci-calmodulina, estan implicada en funcions cel·lulars com la regulació de l’expressió gènica, la ...

Regulation of synthesis, transport and accumulation of lipids in Lipid droplets by Acetyl-CoA carboxylase and Caveolins. How cells accumulate lipids but reduce lipotoxicity

Morales Paytuví, Frederic (Date of defense: 2022-02-04)

The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During the last years, the ...

Replication stress: mechanisms and molecules involved in DNA replication progression and reinitiation

Feu i Coll, Sònia (Date of defense: 2019-03-28)

This thesis investigates the mechanisms that are activated in response to replication stress induced with hydroxyurea, an agent that causes deoxyribonucleotides depletion and arrest cells in S phase, in the non-transformed ...

Study of pro-apoptotic protein RTP801 homeostasis and its regulation by NEDD4 in Parkinson's disease

Canal de la Iglesia, Mercè (Date of defense: 2016-06-01)

Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons of the Substantia Nigra pars compacta (SNpc) and the presence of cytoplasmic protein inclusions named Lewy Bodies. Current treatments are directed ...

Study of the mTOR pathway in neurodegenerative diseases: from synapses to genes

Martín Flores, Núria (Date of defense: 2018-12-14)

Huntington's disease (HD) and Parkinson's disease (PD) are devastating neurodegenerative diseases that progress with the death of selective neuronal subpopulations. Neuronal dysfunction and death are consequence of multiple ...

Technological insights into a histopathological and protein composition analysis of aortic aneurysms in Marfan syndrome

López Guimet, Júlia (Date of defense: 2018-04-25)

The aorta is the main artery of the body, whose function is to collect the blood ejected by the heart and distribute it to all tissues. The elastic degree of the aortic wall necessary to withstand blood pressure is mainly ...