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Browsing Departament de Biomedicina by Subject "616.8"

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    Evaluation of therapeutic targets for the treatment of behavioral alterations and neuropathology in Huntington’s disease. The role of histone deacetylase 3 and p75 neurotrophin receptor 

    Suelves Caballol, Núria (Date of defense: 2018-07-23)

    Huntington’s disease (HD) is a rare genetic disorder caused by an aberrant expansion of a CAG trinucleotide in the huntingtin gene (Htt). The neuropathology of the disease is characterized by progressive neuronal dysfunction ...

    Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease 

    Rodríguez Urgellés, Ened (Date of defense: 2022-01-20)

    Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...

    Mecanismes neuronals de la picor aguda i crònica en neurones sensorials: implicació del canal TRESK 

    Andrés Bilbé, Alba (Date of defense: 2020-11-13)

    [cat] TRESK (K2P18.1) és un canal de potassi de fuga que s’expressa en algunes subpoblacions de neurones sensorials, on modula el potencial de membrana en repòs, la descàrrega de potencial d’acció i l’excitabilitat neuronal. ...

    Study of pro-apoptotic protein RTP801 homeostasis and its regulation by NEDD4 in Parkinson's disease 

    Canal de la Iglesia, Mercè (Date of defense: 2016-06-01)

    Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons of the Substantia Nigra pars compacta (SNpc) and the presence of cytoplasmic protein inclusions named Lewy Bodies. Current treatments are directed ...

    Study of the mTOR pathway in neurodegenerative diseases: from synapses to genes 

    Martín Flores, Núria (Date of defense: 2018-12-14)

    Huntington's disease (HD) and Parkinson's disease (PD) are devastating neurodegenerative diseases that progress with the death of selective neuronal subpopulations. Neuronal dysfunction and death are consequence of multiple ...