Now showing items 21-40 of 300

    Biomedical studies of human adenosine deaminase acting on transfer RNA and related therapeutic strategies 

    Roura Frigolé, Helena (Date of defense: 2018-07-27)

    Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, ...

    Biopharmaceutical study of therapeutic efficacy of nanostructured formulations made from products of natural origin 

    Bustos Salgado, Paola (Date of defense: 2021-06-22)

    This research work was aimed at the characterization in vitro, ex vivo and in vivo of nanostructured systems which independently contain a natural flavanone extracted from Eysenhardtia platycarpa and another four flavanones ...

    Biophysical Techniques for the Investigation of Protein-Ligand Complexes 

    Scaffidi, Salvatore (Date of defense: 2021-01-15)

    Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...

    Biotechnological production of rosmarinic acid and ruscogenins. Scaling up the optimized processes to benchtop bioreactors 

    Khojasteh, Abbas (Date of defense: 2019-11-22)

    Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. Interest in RA is growing ...

    Broadening Adenoviral Oncolysis in PDAC: Interrogation of Patient-Derived Organoids for personalized virotherapy and modulation of miRNA content to boost adenoviral potency 

    Raimondi, Giulia (Date of defense: 2020-06-08)

    The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of oncolytic adenoviruses ...

    Capacitat predictiva de l’estimació de la funció renal sobre la cinètica d’eliminació de ganciclovir 

    Palacio Lacambra, María Eugenia (Date of defense: 2018-12-20)

    L'estimació de la funció renal ha de ser el més precisa possible per ajustar correctament la dosi dels fàrmacs, especialment els que s'eliminen via renal com el ganciclovir. Les equacions CKD-EPI i MDRD han demostrat ser ...

    Caracterització funcional de LOXL2 en el rabdomiosarcoma alveolar 

    Almacellas Rabaiget, Olga (Date of defense: 2018-11-16)

    El rabdomiosarcoma (RMS) és el sarcoma de parts toves més comú en nens i adolescents que representa un 3-4 % dels càncers infantils. En canvi, és molt menys freqüent en adults. Principalment consisteix en dues variants ...

    Caracterització morfològica i molecular i estudi epidemiològic d’espècies d’Anisakis i Hysterothylacium (Nematoda: Ascaridoidea) en peixos de consum habitual procedents de l’Atlàntic Nord-Est i del Mediterrani 

    Roca Geronès, Xavier (Date of defense: 2019-12-18)

    Aquest treball engloba l’estudi d’espècies de nematodes ascaridoïdeus de les famílies Anisakidae i Raphidascarididae paràsites de peixos marins arreu del món que presenten un interès sanitari i/o comercial. Dins la família ...

    Caracterización de las vesículas de membrana de Shewanella vesiculosa M7(T) 

    Baeza Lara, Nicolás (Date of defense: 2021-03-13)

    La presente Tesis Doctoral se enmarca en el proyecto CTQ2014-59632-R concedido por el ministerio de economía y competitividad al grupo de investigación. El trabajo se ha centrado en caracterizar las vesículas de membrana ...

    Characterization of the functional connection between the BROMODOMAIN and EXTRATERMINAL DOMAIN PROTEIN 9 (BET9) and the circadian clock in Arabidopsis thaliana 

    Maric, Aida (Date of defense: 2021-11-05)

    The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing organisms to anticipate ...

    Characterization of the proteome and palmitoylome alterations induced by palmitic and oleic acids in OSCC cells 

    Urdiroz Urricelqui, Uxue (Date of defense: 2022-04-07)

    El papel que juega el metabolismo lipídico en la progresión del cáncer está siendo revisado. Estudios recientes de nuestro laboratorio demuestran que el tratamiento con ácido palmítico (AP) de células en cultivo o ...

    Chemical approaches to the study of the ceramide synthase activity 

    Izquierdo García, Eduardo (Date of defense: 2020-09-14)

    Sphingolipids (SLs) are one of the major classes of lipids in eukaryotes. In addition to being essential structural components of cell membranes, SLs also play capital roles as signalling molecules. Ceramides (Cer) are a ...

    Child behavior, feeding practices, and health in the context of obesity 

    Juton, Charlotte (Date of defense: 2023-03-09)

    [eng] Childhood obesity is a global public health problem with aggravating consequences during adulthood, including cardiovascular disease, type 2 diabetes, musculoskeletal disorders, and some types of cancers. The reason ...

    Cholesteryl oleate-loaded solid lipid nanoparticles for the vectorization of nucleic acids 

    Suñé Pou, Marc (Date of defense: 2019-07-12)

    Cationic Solid Lipid Nanoparticles (cSLNs) are one of the most promising nonviral vectors for gene therapy and DNA / RNA delivery. The aim of this thesis is the development and research of new formulations of SLNs that ...

    Chronobiological related factors and weight loss evolution in severe obese patients undergoing bariatric surgery 

    Ruiz Lozano, Tania Pamela (Date of defense: 2016-11-30)

    Currently, the most effective treatment for severe obesity resulting in a large and marked weight loss is bariatric surgery (BS) (Courcoulas, AP et al. 2013).However, several studies have shown that weight loss outcomes ...

    Colloidal lipid gels: A novel approach to structure dispersions of lipids 

    Talló Domínguez, Kirian (Date of defense: 2021-06-17)

    Lipids are essential components in most living organisms whose functionality varies with their chemical structure. In an aqueous environment, diluted dispersions of phospholipids tend to form vesicles and other bilayered ...

    Comprehensive high performance thin layer chromatography (HPTLC) fingerprinting in quality control of herbal drugs, preparations and products 

    Arruda Frommenwiler, Débora (Date of defense: 2020-10-27)

    Quality control of herbals has its roots in the study of morphoanatomic and organoleptic characters. Nevertheless, in the last century, with the evolution of analytical chemistry, the quality control rapidly evolved from ...

    Computational and biophysical approaches for the discovery of Tribbles pseudokinases modulators 

    Salamanca Viloria, Juan (Date of defense: 2022-05-27)

    Tribbles (TRIB) homologues proteins are a family of three pseudokinases withan important role in controlling immunity, metabolism, and cancer throughprotein-protein interactions (PPIs). TRIB pseudokinases have the same ...

    Computational Study of the Structure and Dynamics of Androgen Receptor Polyglutamine Tract 

    Topal, Busra (Date of defense: 2020-01-08)

    Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative disorders called ...

    Connection between viral genetic diversity and clinical manifestation of Papillomavirus infection = Connexió entre la diversitat de genotips virals i les manifestacions clíniques de la infecció pel virus del Papil·loma 

    Félez Sánchez-Ocaña, Marta (Date of defense: 2017-06-29)

    Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides only limited protection ...