Now showing items 21-40 of 300
Roura Frigolé, Helena (Date of defense: 2018-07-27)
Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, ...
Bustos Salgado, Paola (Date of defense: 2021-06-22)
This research work was aimed at the characterization in vitro, ex vivo and in vivo of nanostructured systems which independently contain a natural flavanone extracted from Eysenhardtia platycarpa and another four flavanones ...
Scaffidi, Salvatore (Date of defense: 2021-01-15)
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...
Khojasteh, Abbas (Date of defense: 2019-11-22)
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. Interest in RA is growing ...
Raimondi, Giulia (Date of defense: 2020-06-08)
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of oncolytic adenoviruses ...
Palacio Lacambra, María Eugenia (Date of defense: 2018-12-20)
L'estimació de la funció renal ha de ser el més precisa possible per ajustar correctament la dosi dels fàrmacs, especialment els que s'eliminen via renal com el ganciclovir. Les equacions CKD-EPI i MDRD han demostrat ser ...
Almacellas Rabaiget, Olga (Date of defense: 2018-11-16)
El rabdomiosarcoma (RMS) és el sarcoma de parts toves més comú en nens i adolescents que representa un 3-4 % dels càncers infantils. En canvi, és molt menys freqüent en adults. Principalment consisteix en dues variants ...
Roca Geronès, Xavier (Date of defense: 2019-12-18)
Aquest treball engloba l’estudi d’espècies de nematodes ascaridoïdeus de les famílies Anisakidae i Raphidascarididae paràsites de peixos marins arreu del món que presenten un interès sanitari i/o comercial. Dins la família ...
Baeza Lara, Nicolás (Date of defense: 2021-03-13)
La presente Tesis Doctoral se enmarca en el proyecto CTQ2014-59632-R concedido por el ministerio de economía y competitividad al grupo de investigación. El trabajo se ha centrado en caracterizar las vesículas de membrana ...
Maric, Aida (Date of defense: 2021-11-05)
The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing organisms to anticipate ...
Urdiroz Urricelqui, Uxue (Date of defense: 2022-04-07)
El papel que juega el metabolismo lipídico en la progresión del cáncer está siendo revisado. Estudios recientes de nuestro laboratorio demuestran que el tratamiento con ácido palmítico (AP) de células en cultivo o ...
Izquierdo García, Eduardo (Date of defense: 2020-09-14)
Sphingolipids (SLs) are one of the major classes of lipids in eukaryotes. In addition to being essential structural components of cell membranes, SLs also play capital roles as signalling molecules. Ceramides (Cer) are a ...
Juton, Charlotte (Date of defense: 2023-03-09)
[eng] Childhood obesity is a global public health problem with aggravating consequences during adulthood, including cardiovascular disease, type 2 diabetes, musculoskeletal disorders, and some types of cancers. The reason ...
Suñé Pou, Marc (Date of defense: 2019-07-12)
Cationic Solid Lipid Nanoparticles (cSLNs) are one of the most promising nonviral vectors for gene therapy and DNA / RNA delivery. The aim of this thesis is the development and research of new formulations of SLNs that ...
Ruiz Lozano, Tania Pamela (Date of defense: 2016-11-30)
Currently, the most effective treatment for severe obesity resulting in a large and marked weight loss is bariatric surgery (BS) (Courcoulas, AP et al. 2013).However, several studies have shown that weight loss outcomes ...
Talló Domínguez, Kirian (Date of defense: 2021-06-17)
Lipids are essential components in most living organisms whose functionality varies with their chemical structure. In an aqueous environment, diluted dispersions of phospholipids tend to form vesicles and other bilayered ...
Arruda Frommenwiler, Débora (Date of defense: 2020-10-27)
Quality control of herbals has its roots in the study of morphoanatomic and organoleptic characters. Nevertheless, in the last century, with the evolution of analytical chemistry, the quality control rapidly evolved from ...
Salamanca Viloria, Juan (Date of defense: 2022-05-27)
Tribbles (TRIB) homologues proteins are a family of three pseudokinases withan important role in controlling immunity, metabolism, and cancer throughprotein-protein interactions (PPIs). TRIB pseudokinases have the same ...
Topal, Busra (Date of defense: 2020-01-08)
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative disorders called ...
Félez Sánchez-Ocaña, Marta (Date of defense: 2017-06-29)
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides only limited protection ...