Now showing items 161-180 of 300

    LIF as a metabolic messenger: study of glucose sensing by NSCLC and LIF-mediated nutrient stress responses 

    Hernández Madrigal, Miguel (Date of defense: 2022-06-17)

    Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and hijack the host nutrient ...

    Los sistemas personalizados de dosificación y su aportación a la seguridad de los pacientes 

    Ruiz-Loscertales, H. (Héctor) (Date of defense: 2017-07-17)

    Los Sistemas Personalizados de Dosificación (SPD) son un sistema de reacondicionado donde el farmacéutico organiza los medicamentos de forma farmacéutica sólida que toma un determinado paciente durante una semana, siguiendo ...

    Mapping protein aggregation by deep mutational scanning 

    Seuma Areñas, Mireia (Date of defense: 2023-01-18)

    [eng] Proteins can adopt multiple conformations and material states, from soluble states to self- assemblies, such as liquid condensates or amyloids. Protein aggregation has been associated with many human diseases but how ...

    Marcadors genètics d'eficàcia i toxicitat en el tractament del càncer colorectal 

    Riera Armengol, Pau (Date of defense: 2020-09-23)

    El càncer colorectal (CCR) és una neoplàsia molt freqüent que causa una elevada mortalitat arreu del món. Els fàrmacs més utilitzats en el seu maneig són quimioteràpics (fluoropirimidines, oxaliplatí i irinotecan), agents ...

    Mecanismos de neuroprotección mediante la modulación de SIRT1 

    Corpas Expósito, Rubén (Date of defense: 2016-12-22)

    El aumento de la esperanza de vida poblacional que ha tenido lugar en las últimas décadas, previsiblemente conducirá a un incremento de la incidencia de enfermedades asociadas con la edad, incluyendo la demencia. La principal ...

    Mecanismos de remodelado y calcificación cardiovascular: papel del receptor nuclear NOR-1 y la LOX 

    Ballester Servera, Carme (Date of defense: 2023-10-16)

    [spa] La calcificación cardiovascular (CCV) afecta a arterias y válvulas comprometiendo su normal funcionamiento y aumentando el riesgo de sufrir accidentes cardiovasculares y de desarrollar hipertrofia cardíaca e insuficiencia ...

    Mecanismos de resistencia a terapias dirigidas contra BRAF(V600E) y estudio de nuevas combinaciones de fármacos en cáncer de colon 

    Ramírez Corpas, Lorena (Date of defense: 2023-01-20)

    [spa] Alrededor del 10% de los pacientes con cáncer colorrectal metastático (mCRC) presentan la mutación BRAF(V600E), mutación que está asociada a una peor respuesta al tratamiento estándar con agentes quimioterapéuticos ...

    Mecanismos de señalización y estrategias terapéuticas de protección en los donantes con parada cardiaca en el trasplante hepático 

    Avalos de León, Cindy Guadalupe (Date of defense: 2020-07-21)

    Cada año, miles de personas fallecen a causa de enfermedades hepáticas en estado terminal, siendo la falta de injertos hepáticos un problema sin resolver en la práctica clínica. Para tratar de resolver esta grave situación ...

    Mecanismos moleculares que regulan el crecimiento, la metástasis y la resistencia a terapias del carcinoma escamoso de piel 

    Bernat Peguera, Adrià (Date of defense: 2019-09-20)

    La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a un crecimiento agresivo, ...

    Mediterranean cuisine and health: A multiapproach exploring the sofrito technique 

    Rinaldi de Alvarenga, José Fernando (Date of defense: 2019-07-18)

    Cooking made humans evolve. Cooking modified our gastrointestinal system, reducing the gut size and energy expenditure for digestion, which enabled the appearance of a more energy-dependent brain. Cooking process have ...

    Metabolic vulnerabilities of rhabdomyosarcoma: insights into the role of ASS1 

    Monaco, Paola (Date of defense: 2022-09-23)

    [eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal translocation. ...

    Metabolismo de esteroles esterificados en plantas: implicación en el desarrollo y la respuesta a estrés 

    Burciaga Monge, Alma Delia (Date of defense: 2020-01-31)

    Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre o conjugada, como ésteres, glicósidos y acilglicósidos de esteroles. Cada especie vegetal tiene su propio perfil cualitativo y ...

    Metal-dependent 2-oxoacid aldolases as versatile biocatalysts for the synthesis of chiral multifunctional compounds 

    Marín-Valls, Roser (Date of defense: 2021-10-01)

    Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical reactions in a highly ...

    Micro- and nanomaterials for drug delivery in skin diseases 

    Limón Magaña, David (Date of defense: 2017-07-21)

    anostructured supramolecular hydrogels and gold nanoparticles, as two kinds of nanomaterials, were synthsized, characterized and evaluated for their potential as drug delivery systems. Two bis-imidazolium cationic ...

    Mitochondrial and cell cycle functions of SLIMP 

    Antolin Fontes, Albert (Date of defense: 2019-03-07)

    The mitochondrial Seryl-tRNA Synthetase (SerRS2) is a member of the class II tRNA synthetase family. The mature enzyme catalyses the ligation of serine to tRNASer in mitochondria. During the process of constructing a model ...

    Modular evolution of domain repeat proteins. Metal-binding and domain repeats of Metallothioneins in molluscs and chordates 

    Calatayud Robert, Sara (Date of defense: 2021-12-20)

    Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During protein evolution, ...

    Molecular basis of p38a MAPK signaling 

    Gutierrez Prat, Núria (Date of defense: 2018-10-03)

    Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...

    Molecular mechanism of dBigH1 action 

    Tatarski, Miloš (Date of defense: 2018-09-21)

    INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...

    Molecular segregation at multiple scales in perylene-based systems for the preparation advanced materials 

    Pérez Calm, Adrià (Date of defense: 2023-07-28)

    [eng] This thesis addresses molecular segregation in perylene-based systems, including lyotropic chromonic liquid crystals and water-in-water emulsions. These systems offer several advantages compared to conventional ...

    Molecular Self-Assembly for the preparation of novel nanostructured materials 

    Magaña Rodríguez, José Rodrigo (Date of defense: 2017-02-09)

    In this thesis, the phase behavior in water of a technical grade diglycerol-based surfactant (C41V) and a group of dyes (Quinaldine Red, Pyronin Y, N-Alkylthiacarbocyanines, Oxacarbocyanines, Pinacyanol and Alcian Blue) ...