Browsing Facultat de Farmàcia i Ciències de l'Alimentació by Title

On the usage of lipophilic descriptors for molecular similarity evaluation

Vázquez Lozano, Javier (Date of defense: 2019-09-13)

Three-dimensional ligand-based virtual screening methods have been used for many years in drug discovery, with a variable success depending on different factors, such as the complexity of the target system or the suitability ...

Oncolytic adenoviruses expressing transgenes targeting the tumor stroma to enhance the antitumor efficacy

Sostoa Pomés, Jana de (Date of defense: 2019-05-31)

Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the efficacy of oncolytic ...

Optical control of endogenous receptors and cellular excitability with light

Garrido Charles, Aida (Date of defense: 2020-01-15)

Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons, one single ...

Optimisation of a Tissue Engineering Product based on Mesenchymal Stromal Cells aiming to regenerate bony tissue

Vivas Pradillo, Daniel (Date of defense: 2018-12-14)

Bone is a highly organised and specialised connective tissue that provides a rigid, protective and supporting framework to the body. In addition to this, bone is unique in its capacity to self-regenerate without the ...

Optimització del tractament amb infliximab en la malaltia inflamatòria intestinal: implantació de la monitorització farmacocinètica

Santacana Juncosa, Eugènia (Date of defense: 2020-10-07)

L'èxit dels agents biològics pel tractament de la malaltia inflamatòria intestinal es veu reduït pel fet que no tots els pacients responen bé al tractament i està descrit que fins a un 40% dels pacients que responen ...

Optimización de métodos para el estudio del riesgo asociado a la contaminación fecal del agua y alimentos: cuantificación de patógenos y del riesgo de infecciones virales y análisis metagenómico de virus asociados a hepatitis

Gonzales Gustavson, Eloy Anibal (Date of defense: 2018-02-16)

El agua es esencial para el sostenimiento de la vida en la tierra, por lo tanto, la calidad debe ser controlada para garantizar su uso de forma segura. Los objetivos planteados en esta tesis están orientados a la optimización ...

Papel de la proteína lisosomal LAPTM4B en Leucemia Mieloide Aguda

Delgado Martínez, Jennifer (Date of defense: 2023-07-06)

[spa] La leucemia mieloide aguda (LMA) es una enfermedad altamente heterogénea que hoy en día continúa demandando nuevos avances terapéuticos para hacer frente a su alta mortalidad. Este trabajo se ha centrado en explorar ...

Parasitación de Cornu aspersum Müller, 1774 (Helicidae) por metacercarias del género Brachylaima sensu lato Dujardin, 1843 (Brachylaimidae): tratamiento antihelmíntico y consumo humano

Gállego Franco, Laia (Date of defense: 2017-09-15)

El caracol de consumo humano Cornu aspersum actúa como hospedador intermediario en el ciclo biológico de Brachylaima spp. albergando metacercarias libres en riñón. Su ingestión insuficientemente cocinados permitiría a las ...

Pathophysiology of immune-related complications in Lysinuric Protein Intolerance

Sotillo Rodríguez, Fernando (Date of defense: 2018-02-16)

Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino acids, which drives a ...

Phase Combination and its Application to the Solution of Macromolecular Structures: Developing ALIXE and SHREDDER

Millán Nebot, Claudia Lucía (Date of defense: 2018-09-21)

Phasing X-ray data within the frame of the ARCIMBOLDO programs requires very accurate models and a sophisticated evaluation of the possible hypotheses. ARCIMBOLDO uses small fragments, that are placed with the maximum ...

Photoswitchable ligands targeting beta-adrenoceptors for in vitro, in vivo and structural studies

Duran Corbera, Anna (Date of defense: 2022-04-22)

G protein-coupled receptors (GPCRs) are a large family of membrane proteins responsible for signaling transduction processes. Due to their roles in modulating essential physiological functions, GPCRs are classical ...

Pla de desenvolupament d’una nova combinació de fàrmacs pel tractament de la Síndrome de l’Ovari Poliquístic: del mercat al mercat

Torres Ferraz, Rosa (Date of defense: 2018-12-20)

Actualment no existeix cap medicament aprovat pel tractament de la Síndrome de l’Ovari Poliquístic (PCOS), un dels desordres endocrins més freqüent en dones en edat reproductiva, amb una prevalença creixent i que es ...

Polimedicación y Prescripción “off-label” del Paciente con Daño Cerebral Adquirido y Lesión Medular

Merino Méndez, Raquel (Date of defense: 2021-12-13)

OBJETIVOS: Describir y analizar la prevalencia de la polimedicación y de la prescripción “off-label” de los pacientes con daño cerebral adquirido (DC) y con lesión medular (LM) que estaban ingresados en un hospital de ...

Polyamine metabolism during the defense response to Pseudomonas syringae in Arabidopsis thaliana

Arafaty, Nazanin (Date of defense: 2021-04-30)

The topic of this thesis is to investigate the polyamine metabolism during defense response in Arabidopsis thaliana. I mainly focused on the alteration of polyamine metabolism in different layers of plant immunity triggered ...

Polycomb Repressive Complex 1 functions in differentiation and myelodysplastic syndromes

Palau de Miguel, Anna (Date of defense: 2016-11-30)

Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) components. On the one ...

Polycyclic group optimization in 11β-HSD1 inhibitors and their pharmacological evaluation

Leiva Martínez, Rosana (Date of defense: 2017-09-22)

The present PhD Thesis evolves around the design, synthesis and pharmacological evaluation of novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Given that the enzyme active site includes a hydrophobic ...

Population pharmacokinetic-pharmacodynamic modeling in solid organ transplantation: Basis of personalized immunosuppression

Quintairos Domenech, Luis (Date of defense: 2021-07-08)

Despite advances in immunosuppression, allograft rejection and clinical outcomes remain a challenge in solid organ transplantation. Currently, the immunosuppressive treatment’s individual adjustment is guided by the ...