Now showing items 26-32 of 32

    Selective roles of the Nuclear Receptors LXR in the transcriptional control of classical and alternative macrophage activation = Efectos selectivos de los receptores nucleares LXR en el control transcripcional de la activación clásica y alternativa de macrófagos 

    León Moreno, Theresa Elizabeth (Date of defense: 2013-10-30)

    Nuclear receptor LXR is a ligand dependent transcription factor. The activating ligands of LXR are specific oxidized forms of cholesterol (oxysterols) and intermediate products of the cholesterol biosynthetic pathway. This ...

    Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación 

    Torres Núñez, Eva (Date of defense: 2014-02-21)

    The Extracellular Matrix (ECM) is a complex network secreted by cells that serves as a structural element in tissues and also influences their development and physiology. More specifically, the extracellular matrix helps ...

    Studies on the function and regulation of glucose transporters GLUT2 and GLUT4 in teleost fish / Estudios sobre la función y regulación de los transportadores de glucosa GLUT2 y GLUT4 en peces teleósteos 

    Marín Juez, Rubén (Date of defense: 2012-10-26)

    The aim of this thesis was to study the function and regulation of two of the major players in the carbohydrate metabolism regulated by insulin, the facilitative glucose transporters GLUT2 and GLUT4, in teleost fish. In ...

    El trabajo en hipobaria intermitente crónica a gran altitud en Chile: Búsqueda de estrategias preventivas para la fase aguda 

    Silva Urra, Juan (Date of defense: 2015-12-14)

    La modalidad de trabajo a gran altitud en Chile denominada hipobaria intermitente crónica a gran altitud abarca tanto la explotación de la gran minería, como la actividad de los grandes centros astronómicos, puestos ...

    Trex1 and Nbs1 as Regulators of the Macrophage Inflammatory Response 

    Pereira Lopes, Selma Patrícia (Date of defense: 2014-02-20)

    Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabolism was conjectured to have a role in DNA damage repair and cancer. It was unexpected to find that Trex1-/- mice generated ...

    TREX1 and SAMHD1, and Aicardi-Goutières Syndrome 

    Valverde Estrella, Lorena (Date of defense: 2015-02-06)

    Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the cerebrospinal fluid. AGS ...

    Tumors and Ly6Chigh Monocytes 

    Zare, Fatemeh (Date of defense: 2015-02-05)

    Cancer immunotherapy represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy – the current cornerstones of our fight against cancer. It has become clear now, ...