Browsing Facultat de Farmàcia by Subject "576"

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Análisis bioquímico y estructural del factor de transcripción mitocondrial humano A, TFAM, en complejo con la secuencia promotora LSP

Rubio Cosials, Anna (Date of defense: 2013-02-22)

En esta tesis se ha conseguido la caracterización bioquímica, biofísica y estructural del factor de transcripción mitocondrial A humano, TFAM. TFAM presenta múltiples funciones en la biogénesis de la mitocondria y está ...

Biophysical study of the aggregation of the androgen receptor protein in spinal bulbar muscular atrophy

Chiesa, Giulio (Date of defense: 2015-12-11)

Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the coding region for the ...

Combinatorial perspective on the gene expression circuits established by the CPEB-family of RNA binding proteins

Duran Arqué, Berta (Date of defense: 2020-12-21)

The complex changes that take place in the mature Xenopus oocyte and early embryo are orchestrated in the absence of transcription. Until zygotic transcription starts, after the mid-blastula transition, cells ...

Molecular retention mechanisms of the G1 cyclin/Cdk complex in budding yeast

Abd El Rahim Metwally, Galal Yahya (Date of defense: 2016-01-13)

Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...

The Multiple Tasks Endured by PI3K during neural tube development

Torroba Balmori, Mª Blanca (Date of defense: 2016-11-11)

Development of the spinal cord involves coordination between exposure to localized extracellular signals and controlled activation of intracellular signaling pathways. This way, neuroepithelial cells firstly proliferate ...