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Cell death and cytokine-mediated inflammatory responses to glucose deprivation in cancer cells
Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells are more dependent on glucose compared to non-transformed tissue. Targeting the cancer metabolism opens up a new strategy ...
Cell derived-extracellular matrix scaffolds with polylactic acid microcarriers for tissue engineering and cell therapy
Organ shortage for transplantation and the need for new therapies for the treatment of tissular damages have driven the development of an exciting field in research, called tissue engineering (TE). Its potential entails ...
Cell Stress and RNA Splicing in Amyotrophic Lateral Sclerosis: Novel Opportunities for Therapeutic Development
L'ELA és una malaltia neurodegenerativa multifactorial. Atès que actualment és una malaltia incurable sense una causa coneguda, els esforços per descobrir noves dianes terapèutiques estan ben justificats. L'evidència ...
Cell wall composition in relation to photosynthesis
[eng] Photosynthesis is an essential process for plants. To comprehend how diffusive and biochemical CO2 processes involved in photosynthesis occur is of great relevance to understand plant physiology. For decades, ...
Cell-adhesive nanopatterns for musculoskeletal tissue engineering
Injuries and conditions of musculoskeletal tissues are among the main causes of disability worldwide and there is a wide need for improved regenerative therapies. In vitro platforms and biomaterials that aim to guide stem ...
Cell-enriched engineered cardiac grafts improve heart function and promote cardiac regeneration: a novel therapy for myocardial infarction
El infarto de miocardio es una de las enfermedades cardiovasculares de mayor incidencia y mortalidad entre la población mundial. A pesar de los diferentes tratamientos empleados, a día de hoy ninguno de ellos consigue ...
Cell-extrinsic barriers of cellular plasticity: contribution of natural killer cells, T lymphocytes and vitamin B12 to in vivo reprogramming
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...
Cell-penetrating peptides as drug shuttles for pain management and other therapeutic applications
This thesis focuses on one of the biggest challenges facing drug discovery field: the efficient targeted delivery of therapeutic compounds, and how cell-penetrating peptides (CPPs) acting as drug delivery vectors can ...
Cellular and Molecular Mechanisms of Novel Therapies to Ameliorate Liver Sinusoidal Dysfunction in Cirrhotic Portal Hypertension
Increased intrahepatic vascular resistance (IHVR), mainly due to elevated vascular tone together with the maturation of hepatic fibrosis and the drop of the hepatic endothelial function, is the main factor in the development ...
Cellular and Wi-Fi technologies evolution: from complementarity to competition
This PhD thesis has the characteristic to span over a long time because while working on it, I was working as a research engineer at CTTC with highly demanding development duties. This has delayed the deposit more than I ...
Cellular approximations of infinite loop spaces and classifying spaces
Dado un espacio topológico punteado A, E. Dror-Farjoun introduce en 1995 la noción de A-homotopía, donde A y sus suspensiones juegan el mismo papel que las esferas en homotopía clásica. Por tanto se definen los grupos de ...
Cellular Ca2+ homeostasis in the pathophysiology of chronic respiratory diseases
Calcium works as a second intracellular messenger in all cell types and its downstream signalling is a key pathway for many systemic functions. In the lungs, the majority of activating stimuli trigger intracellular calcium ...
Cellular dynamics and molecular mechanisms underlying the 3D organization and connectivity of the statoacoustic ganglion
The statoacoustic ganglion (SAG) is a complex 3D structure composed by neurons in charge of transmitting the information from inner ear hair cells to the CNS. During development, SAG copes with otic tissue demands to ...
Cellular immunotherapy for B-cell lymphoma with B-cell lymphoma with NKT-cell agonists
Las células NKT representan una pequeña población de linfocitos con especificidad única para antígenos glicolipídicos, presentados por el receptor CD1d presente, principalmente, en las células dendríticas. Estas células ...
Cellular mechanisms behind vertebrate limp outgrowth
In this work we use a novel in vivo imaging technique and cell behaviour analysis to investigate the cellular basis of limb bud elongation. Recently, it has become clear that oriented cell activities must be involved in ...
Cellular Mechanisms that affect Periodontal Destruction induced by Bacteria Infection in Diabetic and Non Diabetic Rats
The aim of this study was to evaluate the histologic and cellular response to A.actinomycetemcomitans (A.a) infection, and how diabetes-enhanced TNF-α production and diabetes-enhanced apoptosis contribute to the periodontal ...
Cellular mRNA decay factors involved in the hepatitis C virus life cycle
The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides acting as messengers for ...
Cellular networks for smart grid communication
The next-generation electric power system, known as smart grid, relies on a robust and reliable underlying communication infrastructure to improve the efficiency of electricity distribution. Cellular networks, e.g., LTE/LTE-A ...
Cellular Nonlinear Networks: optimized implementation on FPGA and applications to robotics
L'objectiu principal d'aquesta tesi consisteix a estudiar la factibilitat d'implementar un sensor càmera CNN amb plena funcionalitat basat en FPGA de baix cost adequat per a aplicacions en robots mòbils. L'estudi dels ...
Cellular processing bodies and the hepatitis C virus life cycle : characterization of their dynamic interplay
Els cossos de processament (cossos-P) són grànuls discrets i dinàmics que contenen mRNAs represos en la traducció així com proteïnes involucrades en la degradació dels mRNAs i de la maquinària dels miRNAs. Alguns components ...
