Di Stefano, Bruno (Date of defense: 2014-06-05)
One of the major goals of current stem cell research is understanding the mechanism of somatic cell reprogramming by Oct4, Sox2, Klf4 and Myc (OSKM) into induced pluripotent stem cells (iPSCs). However, ...
Ferreira, Vanessa Miriam dos Reis (Date of defense: 2010-11-22)
Xkid is a Xenopus chromokinesin required for metaphase chromosome alignment and for meiosis I to meiosis II transition in oocytes. The aim of this work was to study the regulation of Xkid by phosphorylation ...
Brckalo, Tamara (Date of defense: 2011-01-24)
The focus of this work was to functionally characterize the CD300e receptor expressed in human monocytes and myeloid dendritic cells and investigate the implications that receptor engagement has on their ...
Guha, Sanjib Kumar (Date of defense: 2015-12-18)
X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder. The genetic bases for all its different phenotypic variants are mutation in the gene encoding the peroxisomal ATP-binding ...
Cassis, Linda (Date of defense: 2015-10-29)
Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation ...
Voltes Cobo, Adrià (Date of defense: 2018-12-18)
The hindbrain boundary cell population (BCP) is specified at the interface between adjacent compartments during embryonic development of the posterior brain. Hindbrain BCP is a non-neurogenic population ...
Barra Quaglia, Carolina M. (Date of defense: 2014-10-06)
Los sinusoides del bazo humano promueven la lenta percolación de la sangre, favoreciendo la captura de antígeno por los fagocitos y linfocitos del sistema inmune local. Estratégicamente posicionadas ...
Maseres Javaloy, Pedro (Date of defense: 2018-03-12)
The p38 mitogen activated protein kinase (MAPK) has a crucial role in cells’ stress adaptation and survival. It also plays a role in physiological processes such as differentiation of skeletal muscle ...
Giangarrà, Valeria (Date of defense: 2013-07-25)
En el capitulo I mostramos la caracterización funcional de la ribosa-metiltransferasa de cap I en Xenopus laevis. Se trata de una enzima localizada tanto en el núcleo como en el citoplasma y que tras ...
Carbonell Núñez, Caterina (Date of defense: 2016-12-19)
Cells have the ability to respond and adapt to environmental changes through activation of stress-activated protein kinases (SAPKs). Activation of the p38 SAPK is critical to elicit the early gene ...