Bartrolí Comellas, Mariona (Date of defense: 2018-11-16)
Targeting cancer metastasis has gained considerable importance in the recent years when aiming to increase patients’ overall survival. In Renal Cell Carcinoma (RCC), the discovery of metastatic biomarkers ...
Jiménez Félix, Alejandro (Date of defense: 2021-01-11)
This thesis is centered on the study of PolyPurine Reverse Hoogsteen (PPRH) hairpins technology as a tool for both gene silencing and gene editing. PolyPurine Reverse Hoogsteen (PPRH) hairpins are ...
Bayod Giron, Carles (Date of defense: 2021-05-07)
The nuclear receptors (NR) modulate gene transcription in a ligand-dependent manner throughout different mechanisms. A set of NR, including PPARγ and LXR, are important regulators of carbohydrate and ...
Aubets Gil, Eva (Date of defense: 2021-09-19)
This work is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as a gene silencing tool, and on the search of alternative methods for their delivery, including viral and non-viral ...
Morcillo Sánchez, Melisa (Date of defense: 2021-03-24)
Obesity is the most common metabolic disorder that have alarmingly increased all over the world in the last few decades. The hormone insulin is one of the major endocrine axis deregulated in obesity and ...
Riba Baques, Marta (Date of defense: 2022-03-11)
Corpora amylacea (CA) in the human brain are polyglucosan aggregates that were first described by J.E. Purkinje in 1837. They are intracellular astrocytic bodies that accumulate mainly in perivascular, ...
Rio Aige, Karla (Date of defense: 2023-09-22)
[eng] Newborns have limited ability to fight infections due to an immature adaptative immune response. As a result, they depend on mechanisms of maternal immune transfer, such as placental transfer and ...
Reyes Farías, Marjorie (Date of defense: 2023-10-03)
[eng] Obesity is a chronic condition, with a multifactorial etiology whose incidence has tripled in the last four decades. This condition is associated with a low-grade inflammation caused by an activation ...