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Ara mostrant els elements 23599-23618 de 42940
Investigating Glial Contributions During Parkinson’s Disease Pathogenesis Using Patient-Specific iPSC-Derived Cells
La malaltia de Parkinson (PD) s'associa amb la degeneració de les neurones dopaminèrgiques del mesencèfal ventral (vmDA) i l'acumulació d'inclusions citoplasmàtiques, els cossos de Lewy, compostos principalment per la α ...
Investigating malaria transmission and assessing control activities in preparation for a malaria elimination strategy in the Lihir Islands of Papua New Guinea
[eng] INTRODUCTION: Papua New Guinea (PNG) has the highest malaria transmission rates in the Pacific region. The Lihir Islands of PNG comprise the islands of Aniolam, where a gold mine is located, Masahet, Mahur and ...
Investigating New and Existing Management and Nutritional Strategies to Improve Productive Performance and Feed Efficiency in Grower-Finisher Pigs
El rendiment productiu i l’eficiència alimentària són crucials per la sostenibilitat de la producció porcina. El període de creixement-finalització representa més del 65% del cost total de producció, sent el període més ...
Investigating pathological extracellular matrix architecture
[eng] The composition and architecture of the extracellular matrix (ECM), and their dynamic alterations, play an essential regulatory role in numerous cellular processes. Furthermore, structural, and biochemical properties ...
Investigating protein complexes potentially governing microtubule-dependent MBP mRNA distribution
La localització de molècules d'ARNm permet regular la síntesi de proteïnes localment i temporalment i això és vital per molts processos cel·lular fonamentals. A Oligodendròcits el transport de l'ARNm de la proteïna bàsica ...
Investigating quantum many-body systems with tensor networks, machine learning and quantum computers
(English) We perform quantum simulation on classical and quantum computers and set up a machine learning framework in which we can map out phase diagrams of known and unknown quantum many-body systems in an unsupervised ...
Investigating Reliability and Construct Validity of Situational Test of Socio-Emotional Competencies in the Iranian Context
El present estudi analitza la fiabilitat i la validesa de constructe del Test Situacional del Desenvolupament de Competències Socioemocionals en el context d’Iran. Per això es va traduir el test, es va validar per experts, ...
Investigating senescence in cellular plasticity and tissue regeneration
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through cell intrinsic cell-cycle inhibition and arrest. However, through secretion of specific proteins, termed the senescence-associated ...
Investigating sperm RNA dynamics in intergenerational inheritance using nanopore sequencing
The aim of this thesis is to delve into sperm RNA dynamics during maturation and paternal inheritance. To obtain an integrative multi-omics view of sperm RNA during these processes, I turned to the new direct RNA sequencing ...
Investigating the factors influencing professional identity on first-year university students: an exploratory study
Considerant que la Identitat Professional actua com a mediadora de la decisió d’escollir un determinat camí professional, la present tesi té com objectiu contribuir en el coneixement sobre aquest fenomen, en l’àmbit ...
Investigating the genetic component of Parkinson’s disease through the use of human induced pluripotent stem cells and gene editing
Despite the advances in the identification of genes and proteins involved in Parkinson’s disease (PD), there are still appreciable gaps in our understanding of the mechanisms underlying the chronic neurodegenerative process ...
Investigating the Middle to Upper Paleolithic Transition from the Sites in Khorramabad Valley; Western Iran: with Special Reference to Kaldar Cave
Aquesta tesi doctoral conté una recerca dirigida a la comprensió de la transició del Paleolític mitjà al superior a les muntanyes del Zagros, i de les seves implicacions en debats mes globals. Aquesta recerca és el resultat ...
Investigating the molecular basis of Drosophila L(3)mbt and pins malignant tumors
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried out to this end taking ...
Investigating the role of Gli2 in mouse embryonic stem cells and mouse embryogenesis
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes
Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of ...
Investigating the role of testis-mitochondiral genes in Drosophila lethal (3) malignant brain tumor
Genetically tractable models such as Drosophila melanogaster may help to identify new approaches to halt malignant growth. During my doctoral thesis, I performed a screen to find mitochondrial genes required for the growth ...
Investigating the role of transcription factor Nkx1-2 in mouse embryonic stem cell pluripotency, self-renewal and differentiation
Mouse embryonic stem cells (ESCs) require extracellular signals to induce the expression of intrinsic core pluripotency factors: Oct4, Sox2 and Nanog, known as the OSN triad. Notably, the Wnt/β-catenin pathway has been ...
Investigating the role of Wnt/β-catenin pathway in pluripotency and somatic cell reprogramming
The adaptive response of cells to external stimuli is an intriguing mechanism at the basis of the existence of life itself. For this purpose, signalling pathways and gene regulatory networks elegantly evolved translating ...
Investigating the roles of cellular senescence in embryogenesis and aging
Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex biological processes ...
Investigating the Signs and Sounds of Cypro-Minoan
The aim of this dissertation is to advance our knowledge of Cypro-Minoan, a group of undeciphered syllabic inscriptions dated roughly to the 16th or 15th through the 11th centuries BCE and found mostly on Cyprus, with small ...
