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Modulation of the RNAi pathway by chemically modified siRNA molecules
To direct post-transcriptionally gene silencing, RNAi machinery exploits the formation of base pairs between the loaded guide strand and the complementary mRNA. The Ago2 protein is the “slicer” effector of the RISC and ...
Modulation of the stretch reflex arc to improve functional recovery after peripheral nerve injury
Després d’una lesió del sistema nerviós perifèric, aquest té la capacitat de regenerar però la seva recuperació funcional sol ser limitada, principalment degut a la inespecificitat de la reinnervació dels òrgans perifèrics ...
Modulation of transcription of sea urchin histone genes by a nuclear protein fraction: studies on the specificity of this activity using the amphibian oocyte microinjection assay
The early and late histone genes from the sea urchin Strongylocentrotus purpuratus constitute a pair of developmentally regulated genes. The early genes are expressed throughout oogenesis and early development until the ...
Modulation strategies for the neutral-point-clamped converter and control of a wind turbine system
Els convertidors multinivell són topologies de convertidors d’electrònica de potència que poden generar tres o més nivells de voltatge en cadascuna de les fases de sortida. Com a resultat, els voltatges i corrents generats ...
Modulation-enhanced localization microscopy: using patterned illumination for super-resolution microscopy: from the localization of single molecules to the descripton of nano-structures
This thesis introduces SIMPLE (Structured Illumination based Point Lo- calization Estimator), a novel super-resolution technique in fluorescence microscopy. By combining standing-wave patterned illumination with single-molecule ...
Modulatory effects of adenosine on the activational component of motivated behaviors regulated by dopamine: behavioral and immunohistochemical studies
For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the rewarding impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ...
Moduli spaces of vector bundles on algebraic varieties
This thesis seeks to contribute to a deeper understanding of the moduli spaces <i>M-sub X, H (r; c1,., Cmin{r;n}</i>) of rank <i>r</I>, <i>H</i>-stable vector bundles E on an <i>n</i>-dimensional variety <i>X</I>, with ...
Moira. Destino y Iibertad en el pensamiento antiguo
En el presente trabajo de investigación nos hemos preguntado por la evolución de las primeras nociones de destino y libertad en el mundo antiguo y por la relación entre ambas. La tesis principal que defendemos es que los ...
Molecular alterations in eutopic endometrium of women with endometriosis and implications in its diagnostic
La endometriosi és una malaltia benigna que afecta a un 10-15% de les dones en edat reproductiva I els seus símptomes principals són dolor i infertilitat. El seu diagnòstic pot ser retardat fins a 6,7 anys de mitjana, i ...
Molecular alterations in metastatic breast cancer and efficacy of PI3K/AKT/mTOR inhibitors in early phase clinical trials
Antecedentes: Las alteraciones de la vía de PI3K/AKT/mTOR (PAM) son frecuentes en cáncer de mama metastásico (CMM). Actualmente hay varios inhibidores de PAM en desarrollo. Posibles biomarcadores de respuesta (y resistencia) ...
Molecular alterations in muscle wasting and cachexia : therapeutic approaches in animal models
Cachexia and muscle deconditioning, which are the major comorbidities in patients with chronic diseases including lung cancer (LC), impair disease prognosis. Several biological mechanisms are involved in these two muscle ...
Molecular analysis of MTOC assembly - the role of ninein-like protein
Despite decades of work, the molecular requirements underlying microtubule- organizing center (MTOC) formation at the centrosome remain obscure. Progress is hindered by the complexity of this organelle, which is composed ...
Molecular analysis of ovarian resorption by hydric stress in Blatella germanica
In the present thesis we studied the effects of hydric stress in the ovary of the cockroach Blattella germanica. At morphological level, we described ovarian resorption induced by water deprivation. At a molecular level, ...
Molecular analysis of Smc5/6-dependent sumoylation and ubiquitination
Les cèl·lules eucariotes dediquen grans esforços per mantenir la integritat del seu genoma. Els complexos SMC (Structural Maintenance of Chromosomes), que inclouen la cohesina, la condensina i el complex Smc5/6, coordinen ...
Molecular analysis of the mechanisms involved in THBS4 differential geneexpression in the human brain
Durante las últimas décadas ha crecido el interés en cuestiones como qué nos hace humanos o cómo difiere a nivel molecular el cerebro humano del de nuestros parientes más cercanos. Se han podido identificar cientos de genes ...
Molecular and cellular aspects of proprioceptive control in C. elegans
(English) Locomotion behavior is the output of the integrated clues by the nervous system along with proprioceptive regulation, which encompasses responses such as avoiding, feeding, and reproduction. Mechanosensation, the ...
Molecular and cellular mechanisms of fertilization failure after ICSI
La ICSI és una tècnica de reproducció assistida molt eficient, però la fallada de fecundació (FF) pot ocórrer en un 1-3% dels cicles. La FF té un elevat impacte en els pacients i és molt difícil de predir, diagnosticar i ...
Molecular and cellular mechanisms of heart regeneration in zebrafish
In contrast to mammals, zebrafish do have the ability to regenerate their heart after injury. A better understanding of how regenerationcompetent species do so should help developing strategies to enhance human cardiac ...
Molecular and functional characterization of irem-3, a new activating member of the cmrf/irem family
En los últimos años hemos sido testigos de la identificación de múltiples familias de receptores inmunológicos. En este contexto encontramos la recientemente descrita familia IREM/CD300 localizada en la región cromosómica ...
Molecular and functional characterization of the HP1c complex in Drosophila melanogaster
Unlike characteristic HP1 proteins, the HP1c isoform of Drosophila melanogaster is a euchromatic protein. HP1c forms a complex with the zinc finger proteins ROW and WOC, which are crucial for HP1c function. In the present ...
