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Structural analysis and segmentation of music signals
Con la reciente explosión cuantitativa de bibliotecas y colecciones de música en formato<br/>digital, la descripción del contenido desempeña un papel fundamental para una gestión y<br/>búsqueda eficientes de archivos de ...
Structural analysis for the improvement of SnO(2) based gas sensors
La investigación presentada está centrada en la mejora de sensores de gas conductométricos de Sn02. Se analizan sensores en capa gruesa y en capa delgada. En el primer caso, el polvo de Sn02 necesario para fabricar los ...
Structural analysis of eythropoietin glycans
La eritropoyetina o EPO es una hormona glicoproteica. En los seres humanos adultos, se produce principalmente en el riñón, en respuesta a la reducción de oxígeno en los tejidos (hipoxia tisular). La EPO estimula la ...
Structural analysis of macromolecular folds and the application to phasing
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, their biological ...
Structural analysis of nucleotide binding sites of antimicrobial ribonucleases
Esta tesis abarca un análisis estructural y funcional de las ribonucleasas antimicrobianas. Se han analizado los centros de interacción de ligandos nucleotídicos con la RNasa A como referencia. Los estudios estructurales, ...
Structural analysis of protein interaction networks
Interactions between proteins give rise to many functions in cells. In the lastdecade, highthroughput experiments have identified thousands of protein interactions, which are often represented together as large protein ...
Structural and biomechanical analyses of the upper limb skeleton: implications for functional reconstruction in hominoids
Algunes de les diferències observades entre hominoïdeus no humans i entre grups d’humans en l’esquelet de l’extremitat superior es deuen a diferències en la locomoció i en els patrons d’activitat, respectivament. Les ...
Structural and computational aspects of simple and influence games
Simple games are a fundamental class of cooperative games. They have a huge relevance in several areas of computer science, social sciences and discrete applied mathematics. The algorithmic and computational complexity ...
Structural and dynamical interdependencies in complex networks at meso- and macroscale: nestedness, modularity, and in-block nestedness
Many real systems like the brain are considered to be complex, i.e. they are made of several interacting components and display a collective behaviour that cannot be inferred from how the individual parts behave. They are ...
Structural and electrical characterization of doped graphene and carbon nanotube networks
Graphene, a two-dimensional sp2-hybridized network of carbon atoms has received a remarkable cornucopia of new physics and served as a unique model system, due particularly to its electronic properties, which could have ...
Structural and Fumctional Analysis of the SUMO Proteases SENP6 and SENP7
Intercambiar la especifidad de las isoformas de SUMO1 y SUMO2/3 para SENP6/SENP7 SENP6 y SENP7 son los miembros más divergentes de la familia de proteasas SENP y los únicos miembros que llevan cuatro inserciónes o “loops” ...
Structural and functional analysis of natural protein-based inhibitors and their protease targets
[eng] Several proteases and their antagonistic protein or peptide inhibitors sparked researchers’ interest due to their potential as therapeutic targets. The present thesis, which compiles results obtained in three independent ...
Structural and Functional Analysis of the Glucocorticoid Receptor Multimerization: Implications for Human Pathophysiology
El receptor de glucocorticoides (GR) es un factor de transcripción que se expresa de forma ubicua y controla procesos esenciales para la vida como el metabolismo, la inflamación y la homeostasis. Aunque se han publicado ...
Structural and functional analysis of Zika Virus NS5 protein
Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a positive sense single ...
Structural and functional characterization of Apoptin and design of a monomeric variant with antitumor activity
The main aim of the present study is to characterize the biological and biophysical properties of Apoptin, a viral protein that selectively induces apoptosis of a wide range of tumor cells. Apoptin has been produced and ...
Structural and functional characterization of regulatory metallocarboxypeptidases: Studies on human carboxypeptidases D and Z, and the transthyretin-like domain
Las metalocarboxipeptidasas (MCPs) son enzimas zinc-dependientes que hidrolizan amino ácidos del extremo C terminal en proteínas y péptidos. La primera MCP en ser identificada fue la carboxipeptidasa A1 (CPA1), una enzima ...
Structural and functional characterization of the intrinsically disordered Unique domain of c-Src
Objectives: Objective 1 – Effect of mutations perturbing the ULBR of the Unique domain of c-Src. The first objective of this thesis was the in vitro characterization of the effect of mutations in the ULBR on the ...
Structural And Functional Connectivity Alterations And Their Relationship With Cognitive Impairment In Traumatic Brain Injury
Traumatic Brain Injury (TBI) can be defined as an alteration in brain function or evidence of brain pathology caused by an external force. In this thesis the focus of attention is on brain diffuse axonal injury (DAI). DAI ...
Structural and functional effects of natural phenolic compounds on rhodopsin mutants associated with retinitis pigmentosa
Dietary polyphenols represent a group of secondary metabolites which widely occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. Previous studies have shown the interaction ...
