Browsing by Title
Now showing items 18159-18178 of 41988
Exploring the regulation and function of TIGAR in cancer cells
The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) gene was described in 2006 by Dr. Karen Vousden's group in response to the induction of the tumour suppressor gene p53. Since then, numerous studies have focused ...
Exploring the regulatory mechanisms of the S. cerevisiae Ppz1 protein phosphatase and the molecular basis for its toxicity
Uno de los más notables componentes en la homeostasis de cationes en levaduras es la proteína fosfatasa Ppz1. El papel de Ppz1 es doble: inhibe la entrada de potasio mediante el control de la actividad de los transportadores ...
Exploring the role of climate variability and change in the spillover of zoonotic diseases: towards the development of Early Warning Systems (RWS)
The primary goal of this PhD is to deepen our understanding and improve the modeling capacity of zoonotic spillover, the multilevel process by which pathogens manage to overcome a series of natural barriers and infect other ...
Exploring the role of differential expression of splicing factors and regulators in tissue-specific alternative splicing
Alternative splicing (AS) is an important step in the pathway of gene expression and regulation. The splicing process is catalyzed by the Spliceosome, a complex molecular machinery that is dynamically assembled on the ...
Exploring the role of DYRK1A in RNA polymerase III transcription : DYRK1A as a potential regulator of TFIIIC
The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans. In this Thesis, the ...
Exploring the role of genetics and environment on the neural substrates of word and rule learning
L’origen ambiental i genètic de les diferències individuals en l’aprenentatge de paraules i regles gramaticals és desconegut. Per aquest motiu es van realitzar dos estudis. En el primer, dos grups de bessons, monozigòtics ...
Exploring the role of glycans: A new frontier in disease biomarker research
Els glicans juguen un paper crucial en diversos processos biològics i han emergit com a potencials biomarcadors en la recerca biomèdica i les aplicacions clíniques. Aquests carbohidrats estan implicats en la comunicació ...
Exploring the role of NR2E3 in photoreceptor cell fate determination
The transcription factor NR2E3 participates in photoreceptor cell fate determination as it functions as both transcriptional repressor of cone genes and activator of rod genes. Mutations in NR2E3 cause retinitis pigmentosa ...
Exploring the Role of Third Party Logistic (TPL) Companies as Enablers for Collaborative Systems and Blue Ocean Strategy in Supply Chain Management
[eng] This doctoral thesis investigates the potential of third-party logistics (TPL) companies as key facilitators of collaborative systems and the implementation of the blue ocean strategy within the realm of supply chain ...
Exploring the topical structure of short text through probability models : from tasks to fundamentals
Recent technological advances have radically changed the way we communicate. Today’s communication has become ubiquitous and it has fostered the need for information that is easier to create, spread and consume. As a ...
Exploring the Universe with Quasar Absorption Spectra: correlations among tracers of the mass density field and the impact of ionizing background intensity fluctuations
The work we present in this manuscript revolves around the use of quasar spectra to probe the Universe. Absorption features in the electromagnetic spectrum of bright distant quasars by ionized hydrogen give us access to ...
Exploring the water-energy nexus in urban and tourist areas of the western mediterranean. Empirical findings from Benidorm and Barcelona
La tesi analitza el Nexe Aigua-Energia (WEN) a través d'una metodologia mixta centrant-se en el metabolisme urbà de l'aigua a Benidorm i Barcelona. El cas de Benidorm examina el subministrament d'aigua a escala municipal ...
Exploring the Zn deficiency hypothesis to explain the beneficial effect of therapeutic ZnO in weaning pigs
L’objectiu general de la present tesi doctoral és estudiar l’estatus de Zn dels garrins deslletats i com aquest es veu afectat pel deslletament i la suplementació dietària de Zn, com són els nivells farmacològics de ZnO ...
Exploring through prototyping embodied interaction design developing systems for mathematics learning for children with visual impairments and without
In the last decades new interaction paradigms have emerged: Tangible User Interfaces, ubiquitous computing, wearable devices, mixed- reality among others. Such paradigms extended the user interface beyond the keyboard ...
Exploring twisted bilayer graphene with nano-optics
Nano-optics studies the behaviour of light on the nanoscale. In particular, it probes the interaction of light with objects, often of nanometre-size, and reveals fine details of the material's optical properties. Optoelectronics ...
Exploring urban visitors' mobilities. A multi-method approach
Aquesta tesi doctoral sorgeix de la necessitat d’aprofundir en el coneixement de les mobilitats dels visitants, entendre les decisions que configuren el seu comportament espacio-temporal i identificar i explorar els efectes ...
Exploring what disruptive innovation is and its influence on Spanish incumbents
Disruptive innovation has become one of the most renowned types of innovation in the business world. The results of the preliminary review of the literature on this theory have revealed interesting questions about how ...
Exploring women's inclusion and contribution to the building of infrastructures for peace from grassroots initiatives in Kenya
This doctoral dissertation examines the inclusion and contribution of women in the elaboration and building of sustainable peace by showcasing the historical and institutional evolution of their role in implementing ...
Explotación abusiva de una posición dominante, La.
Los artículos 82 TCE (antes 86 TCE) y 6 LEDC prohíben la explotación abusiva de una posición dominante en el mercado; sin embargo no definen los importantes términos típicos que contienen. Este trabajo se dedica al estudio ...
La explotación sexual de la infancia y la adolescencia: Diseño y validación de una herramienta para la detección del riesgo
[spa] La explotación sexual de la infancia y adolescencia (ESIA) es una forma de violencia sexual que causa un daño profundo y a largo plazo a los niños, niñas y adolescentes, sus familias y la sociedad. La ESIA se produce ...
