Now showing items 35717-35736 of 43048
Sherstoboeva, Elena (Date of defense: 2017-09-15)
Aquesta tesi examina les polítiques de mitjans a Rússia amb l’objectiu d’identificar, principalment des d’un punt de vista jurídic, fins a quin punt han estat objecte d’influència per part del estàndards legals establerts ...
Sáez Borderias, Andrea (Date of defense: 2009-02-20)
This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell ...
Prado Sánchez, Judith (Date of defense: 2012-07-02)
En el trabajo aquí presentado se investigó la participación de los niveles intracelulares de GMP-cíclico (CMPC) en la regulación de diferentes aspectos de la neuroinflamación. En el primer capítulo hemos observado que los ...
Morancho Armisen, Beatriz (Date of defense: 2008-06-19)
NFAT5 is the main regulator of an osmoprotective gene program that is switched on by osmotic stress. Hypertonicity causes a harmful increase in the intracellular concentration of inorganic ions and NFAT5-regulated genes ...
Hernández Ribera, Jordi (Date of defense: 2016-11-23)
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative splicing regulation ...
Carrillo García, Julia (Date of defense: 2021-09-30)
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of ...
Garcia i Fruitós, Elena (Date of defense: 2008-05-08)
All the processes that take place in a cell require one or more proteins, meaning that they are essential components of life. Proteins are macromolecules consisting of amino acid units, all of them being constructed with ...
Pedraz López, Lucas (Date of defense: 2020-01-13)
The perpetuation of life depends on the ability to reproduce. All known forms of life use DNA as genetic information storage. Ribonucleotide reduction is the process by which ribonucleotides (NTPs) are transformed into ...
Meca-Cortés, Oscar (Date of defense: 2014-12-17)
The transcription factor SOX2 is a key determinant of stem cell properties, also involved in the initiation, maintenance and progression of several human cancers. By studying the in vitro phenotypic ...
Martínez Gutiérrez, Alfredo (Date of defense: 2019-12-13)
One of the main causal factors of skin aging is ultraviolet radiation as part of sun exposure. This radiation induces many changes at the molecular level that alter the proper function of skin biological processes, being ...
Ninfali, Chiara (Date of defense: 2019-12-13)
Muscle atrophy, which is characterized by excessive protein catabolism, is one of the major adaptive processes that occur in several physiopathological and clinical conditions, to counteract stressing stimuli. Skeletal ...
Morales Paytuví, Frederic (Date of defense: 2022-02-04)
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During the last years, the ...
Alberdi Ibarzabal, Maria (Date of defense: 2015-07-24)
CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
Subtil Rodriguez, Alicia (Date of defense: 2007-06-27)
El gen humano 11-HSD2 es un modelo para investigar la contribución de los efectos de los receptores de esteroides en células de cáncer de mama. El análisis del promotor mostró que la región distal está implicada ...
Cucarull Martínez, Blanca (Date of defense: 2021-11-25)
[eng] Hepatocellular carcinoma (HCC) is the most common liver cancer and currently the fourth cause of cancer-related death. Since its appearance, the multityrosine kinase inhibitor (MKI) sorafenib has been the standard ...
Zurita Carpio, Alberto (Date of defense: 2023-03-08)
A cèl·lules eucariotes, la mitosi és la fase del cicle cel·lular en què segreguen els cromosomes replicats (anafase) i la cèl·lula es divideix físicament en dues cèl·lules filles durant la sortida de mitosi (citocinesi). ...
Martínez Marchal, Ana (Date of defense: 2019-07-05)
Durant la oogènesi dels mamífers, les oogònies proliferen forman els anomenats cists. Les oogònies entren en meiosis progressant en la profase I i els cists es trenquen al mateix temps que es produeix una mort massiva ...
Arató, Krisztina (Date of defense: 2010-12-20)
DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs are activated by ...
Almeida Ferreira, Ana Patricia de (Date of defense: 2016-02-09)
The final size of a developing organ has to be finely modulated in order to give rise to fully functional organs and organisms. Final size is regulated by the nutritional status of the feeding animal through the activity ...
Ruiz Roig, Clàudia (Date of defense: 2011-12-02)
A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió gènica, que es ...