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Now showing items 35717-35736 of 43048
Regulation of Media in Russia in the context of the council of Europe standars
Aquesta tesi examina les polítiques de mitjans a Rússia amb l’objectiu d’identificar, principalment des d’un punt de vista jurídic, fins a quin punt han estat objecte d’influència per part del estàndards legals establerts ...
Regulation of natural killer and cd4+T cell function by NKG2 C-type lectin-like receptors
This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell ...
Regulation of neuroinflammation by cGMP-mediated pathways.
En el trabajo aquí presentado se investigó la participación de los niveles intracelulares de GMP-cíclico (CMPC) en la regulación de diferentes aspectos de la neuroinflamación. En el primer capítulo hemos observado que los ...
Regulation of NFAT5 by signaling pathways involved in osmotic stress responses and cell growth
NFAT5 is the main regulator of an osmoprotective gene program that is switched on by osmotic stress. Hypertonicity causes a harmful increase in the intracellular concentration of inorganic ions and NFAT5-regulated genes ...
Regulation of NUMB alternative splicing by RBM10 and control of cancer cell proliferation
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative splicing regulation ...
Regulation of Piezo1 channels and its impact on cell division
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of ...
Regulation of recombinant proteína solubility and conformational quality in Escherichia coli
All the processes that take place in a cell require one or more proteins, meaning that they are essential components of life. Proteins are macromolecules consisting of amino acid units, all of them being constructed with ...
Regulation of ribonucleotide reduction in facultative anaerobic pathogens and its influence in bacterial fitness, virulence and biofilm formation
The perpetuation of life depends on the ability to reproduce. All known forms of life use DNA as genetic information storage. Ribonucleotide reduction is the process by which ribonucleotides (NTPs) are transformed into ...
Regulation of self-renewal in colorectal cancer cell models
The transcription factor SOX2 is a key determinant of stem cell properties, also involved in the initiation, maintenance and progression of several human cancers. By studying the in vitro phenotypic ...
Regulation of Sirtuin-dependent skin cell Senescence by dermatology-associated compounds
One of the main causal factors of skin aging is ultraviolet radiation as part of sun exposure. This radiation induces many changes at the molecular level that alter the proper function of skin biological processes, being ...
Regulation of skeletal muscle atrophy by the ZEB1 transcription factor
Muscle atrophy, which is characterized by excessive protein catabolism, is one of the major adaptive processes that occur in several physiopathological and clinical conditions, to counteract stressing stimuli. Skeletal ...
Regulation of synthesis, transport and accumulation of lipids in Lipid droplets by Acetyl-CoA carboxylase and Caveolins. How cells accumulate lipids but reduce lipotoxicity
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During the last years, the ...
Regulation of T cell fates by the transcription factor NFAT5 in different microenvironments
CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
Regulation of the 11beta-hydroxysteroid dehydrogenase type 2 promoter by steroid hormones in breast cancer cells. Convergence of progesterone receptor binding to DNA and JAK/START pathway activation
El gen humano 11-HSD2 es un modelo para investigar la contribución de los efectos de los receptores de esteroides en células de cáncer de mama. El análisis del promotor mostró que la región distal está implicada ...
Regulation of the microenvironment and chemoresistance in liver therapy
[eng] Hepatocellular carcinoma (HCC) is the most common liver cancer and currently the fourth cause of cancer-related death. Since its appearance, the multityrosine kinase inhibitor (MKI) sorafenib has been the standard ...
Regulation of the mitotic exit in eukaryotic cells
A cèl·lules eucariotes, la mitosi és la fase del cicle cel·lular en què segreguen els cromosomes replicats (anafase) i la cèl·lula es divideix físicament en dues cèl·lules filles durant la sortida de mitosi (citocinesi). ...
Regulation of the oocyte pool in mammals
Durant la oogènesi dels mamífers, les oogònies proliferen forman els anomenats cists. Les oogònies entren en meiosis progressant en la profase I i els cists es trenquen al mateix temps que es produeix una mort massiva ...
Regulation of the stability of the protein kinase DYRK1A: establishing connections with the Wnt signaling pathway
DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs are activated by ...
Regulation of tissue growth : a molecular bridge between extrinsic and intrinsic mechanisms = Regulación del crecimiento tisular : un puente molecular entre los mecanismos extrínsecos e intrínsecos
The final size of a developing organ has to be finely modulated in order to give rise to fully functional organs and organisms. Final size is regulated by the nutritional status of the feeding animal through the activity ...
Regulation of transcriptional activation in response to heat stress and osmostress
A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió gènica, que es ...
